Compounds and method for the prevention and treatment of diabetic retinopathy
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Abstract
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The peptide derivatives, which comprise a dihydropyridine⇄pyridinium salt-type redox targetor moiety, a bulky lipophilic function and an amino acid/dipeptide/tripeptide spacer, are used in the prevention and treatment of diabetic retinopathy.
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29 Claims
- 1. A compound of the formula
- 11. A compound of the formula
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