Using activity-based rest disturbance as a metric of sleep apnea

• US 7,117,036 B2
• Filed: 06/27/2002
• Issued: 10/03/2006
• Est. Priority Date: 06/27/2002
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Florio, Joseph J.
• Primary Examiner(s): Prezzuto, Robert E.
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US10/185,776
• Publication Number:
  US 20040002742A1
• Time in Patent Office: 1,559 Days
• Field of Search: 600508-528, 607 1- 28
• US Class Current: 607/19
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

An implantable cardiac device is programmed to monitor short term activity changes that occur while a patient is at rest to produce a sleep disturbance metric that is useful in analyzing and/or treating sleep apnea. After the implantable cardiac device confirms that a patient is at rest, the device monitors an instantaneous signal from an activity sensor to detect variances from normal rest mode activity. When the variances exceed a preset threshold for a short time period (e.g., less than 30–40 sec.), the patient is presumed to be experiencing a form of sleep disturbance as opposed to conscious or wakeful activity. These short term events are recorded as sleep disturbance events. The sleep disturbance metric are reported to a physician as a diagnostic to help ascertain the severity of sleep apnea or to evaluate the effectiveness of pacing therapies being applied to treat sleep apnea.

Claims

1. A method implemented by an implantable cardiac device, comprising:

detecting a heightened level of patient activity while the patient is at rest;

timing a duration of the heightened level of patient activity;

in an event that the duration is less than a predefined time limit, identifying the heightened level of patient activity as sleep disturbance;

administering multiple different pacing therapies to treat sleep apnea; and

evaluating the pacing therapies based on how the pacing therapies affect the sleep disturbances.

2. A method as recited in claim 1, wherein the detecting comprises determining when a patient is in a reclined position and monitoring the patient'"'"'s activity while the patient is in the reclined position.

3. A method as recited in claim 1, wherein the detecting comprises monitoring an instantaneous signal from an activity sensor.

4. A method as recited in claim 1, wherein the time limit is approximately forty seconds.

5. A method as recited in claim 1, further comprising counting the sleep disturbances.

6. A method as recited in claim 1, further comprising storing at least one of a count or a frequency of the sleep disturbances.

7. A computer readable medium having computer-executable instructions that, when executed, direct an implantable cardiac device to perform the method as recited in claim 1.

8. A method comprising:

determining that a patient is at rest;

while the patient is at rest,

monitoring an instantaneous activity signal indicative of a patient'"'"'s activity;

detecting when the instantaneous activity signal exceeds a threshold;

timing a duration that the instantaneous activity signal exceeds the threshold;

in an event that the instantaneous activity signal exceeds the threshold for less than a preset time, recording the patient'"'"'s activity as a sleep disturbance;

administering multiple different pacing therapies to treat sleep apnea;

collecting sleep disturbance metrics for individual pacing therapies; and

evaluating the pacing therapies based on how the pacing therapies affect the sleep disturbance metrics.

9. A method as recited in claim 8, further comprising determining a frequency of sleep disturbances that occur within a predetermined timeframe.

10. A method as recited in claim 8, further comprising counting the sleep disturbances.

11. A method as recited in claim 8, further comprising identifying the patient'"'"'s activity as meaningful activity if the instantaneous activity signal exceeds the threshold for more than the preset time.

12. A computer readable medium having computer-executable instructions that, when executed, direct an implantable cardiac device to perform the method as recited in claim 8.

13. An implantable cardiac device comprising:

sensing circuitry to sense a patient'"'"'s activity;

a sleep disturbance detector to detect when a patient, who is at rest, is experiencing sleep disturbance based on the patient'"'"'s activity;

a therapy module to prescribe a pacing therapy for treating sleep apnea from among multiple different pacing therapies;

a pulse generator to generate pacing pulses according to the prescribed pacing therapy for an evaluation timeframe; and

the sleep disturbance detector counting a number of sleep disturbances experienced during the evaluation timeframe of the prescribed pacing therapy.

14. An implantable cardiac device as recited in claim 13, wherein the sensing circuitry comprises at least one of an activity sensor, a position sensor, an accelerometer, and a posture sensor.

15. An implantable cardiac device as recited in claim 13, wherein the sleep disturbance detector is configured to detect the sleep disturbance by determining when the patient'"'"'s activity rises above a threshold for less than approximately 40 seconds.

16. An implantable cardiac device as recited in claim 13, further comprising a memory to store events of sleep disturbance.

17. An implantable cardiac device comprising:

an activity sensor to sense a patient'"'"'s activity;

a processor to confirm that the patient is at rest based on the patient'"'"'s activity and while the patient is resting, to detect one or more sleep disturbances that occur when the patient'"'"'s activity rises above a threshold for less than a preset time limit;

a memory to store disturbance data pertaining to the sleep disturbances detected by the processor;

a therapy module to prescribe a pacing therapy for treating sleep apnea from among multiple different pacing therapies;

a pulse generator to generate pacing pulses according to the prescribed pacing therapy for an evaluation timeframe; and

the sleep apnea detector measuring durations of episodes experienced during the evaluation timeframe of the prescribed pacing therapy.

18. An implantable cardiac device as recited in claim 17, further comprising a second sensor to detect when the patient is in a reclined position, the second sensor being selected from a group comprising a position sensor, a posture sensor, and an accelerometer.

19. An implantable cardiac device as recited in claim 17, wherein the processor is configured to count a number of sleep disturbances that occur during a predetermined time period.

20. An implantable cardiac device as recited in claim 19, wherein the processor derives a frequency of sleep disturbances based on the number of sleep disturbances that occur during the predetermined time period.

21. An implantable cardiac device as recited in claim 17, wherein the processor comprises a timer to time duration of the patient'"'"'s activity to determine whether the duration is less than the preset time limit.

22. An implantable cardiac device comprising:

activity detection means for detecting when a patient'"'"'s activity rises above a preset threshold;

timing means for timing a duration that the patient'"'"'s activity is above the preset threshold;

identification means for identifying the patient'"'"'s activity as sleep disturbance in an event that the patient'"'"'s activity is above the preset threshold for less than a time limit; and

apnea therapy means for administering a pacing therapy to counteract the sleep apnea from among a multiple of different pacing therapies.

23. An implantable cardiac device as recited in claim 22, wherein the activity detection means comprises:

a sensor to output an activity signal; and

a processor to determine when the activity signal exceeds the preset threshold.

24. An implantable cardiac device as recited in claim 23, wherein the sensor is selected from one or more sensors selected from a group of sensors comprising an activity sensor, an accelerometer, a position sensor, and a posture sensor.

25. An implantable cardiac device as recited in claim 22, wherein the activity detection means comprises:

a posture sensor to detect when the patient is in a reclined position;

an activity sensor to detect the patient'"'"'s activity while the patient is in the reclined position; and

a processor to determine when the activity signal, taken while the patient is in the reclined position, exceeds the preset threshold.

26. An implantable cardiac device as recited in claim 22, further comprising counting means for counting a number of sleep disturbances that occur during a predefined timeframe.

27. An implantable cardiac device as recited in claim 22, further comprising storage means for storing data pertaining to events identified as sleep disturbance.

28. An implantable cardiac device as recited in claim 27, further comprising transmission means for transmitting the data to an external device.

29. An implantable and programmable cardiac device having a memory and a processor, the cardiac device being programmed to perform tasks comprising:

detecting a heightened level of patient activity while the patient is at rest;

timing a duration of the heightened level of patient activity;

in an event that the duration is less than a predefined time limit, identifying the heightened level of patient activity as sleep disturbance; and

administering different pacing therapies for treating sleep apnea and collecting sleep disturbance metrics during individual therapies to evaluate effectiveness of the different pacing therapies.

30. An implantable and programmable cardiac device as recited in claim 29, further programmed to perform tasks comprising detecting the heightened level of patient activity by comparing an instantaneous activity signal to a threshold.

31. An implantable and programmable cardiac device as recited in claim 29, further programmed to perform tasks comprising counting a number of sleep disturbances that occur within a predetermined timeframe.