Apparatus, systems and related methods for dispensing and /or evaluating dry powders
First Claim
1. A method for selecting and/or determining customizable excitation signals for dispensing dry powders, comprising the steps of:
- providing an elongate flow channel having a floor of piezoelectric material;
selecting an angle of orientation for the flow channel such that at least a portion of the flow channel angularly extends in a non-vertical, non-horizontal orientation in the axial direction;
providing a quantity of a target dry powder;
outputting a vibration excitation signal having a first carrier frequency from a signal generator to the piezoelectric material;
flowing the dry powder out of the flow channel;
outputting a vibration excitation signal having a second carrier frequency from the signal generator to the piezoelectric material; and
determining a dispensing vibration excitation signal for the target dry powder that generates a repeatable or a uniform or a repeatable and uniform fluid-like substantially non-agglomerated flow output based on flow data from the first and second vibration excitation signals.
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Accused Products
Abstract
Methods, systems, and computer program products flowably dispense meted amounts of dry powders using a flexing piezoelectric layer to transmit a vibratory signal to the dry powder to facilitate fluidic flow through a flow channel. The apparatus for dispensing dry powders can include: (a) an elongate flow channel having a width, length, and depth, the flow channel having axially spaced apart inlet and outlet ports, wherein the elongate flow channel is configured to extend in an angular orientation of between about 10–75 degrees relative to the axial direction of flow; (b) a flexible piezoelectric layer configured to overlie the flow channel so that, in operation, the piezoelectric layer is able to flex upwardly away from the lowermost portion of the underlying flow channel; and (c) a signal generator operatively associated with the piezoelectric layer, wherein, in operation, the signal generator is configured to output a signal for flexing the piezoelectric layer in the elongate flow channel.
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Citations
28 Claims
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1. A method for selecting and/or determining customizable excitation signals for dispensing dry powders, comprising the steps of:
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providing an elongate flow channel having a floor of piezoelectric material; selecting an angle of orientation for the flow channel such that at least a portion of the flow channel angularly extends in a non-vertical, non-horizontal orientation in the axial direction; providing a quantity of a target dry powder; outputting a vibration excitation signal having a first carrier frequency from a signal generator to the piezoelectric material; flowing the dry powder out of the flow channel; outputting a vibration excitation signal having a second carrier frequency from the signal generator to the piezoelectric material; and determining a dispensing vibration excitation signal for the target dry powder that generates a repeatable or a uniform or a repeatable and uniform fluid-like substantially non-agglomerated flow output based on flow data from the first and second vibration excitation signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of dispensing a dry powder, comprising the steps of:
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providing an elongate flow channel having a powder support floor formed of a flexible piezoelectric material and inlet and outlet ports; directing a quantity of dry powder into the inlet port of the elongate flow channel; vibrating the piezoelectric material with an electric excitation signal so that the piezoelectric material deflects upwardly; flowing the dry powder out of the outlet port responsive to the vibrating step; and adjusting the orientation angle of the elongate floor channel so that the flow channel angularly extends in a non-vertical, non-horizontal configuration and so that the outlet port is lower than the inlet port. - View Dependent Claims (12)
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13. A method of dispensing a dry powder, comprising the steps of:
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providing an elongate flow channel having a powder support floor formed of a flexible piezoelectric material and inlet and outlet pods; directing a quantity of dry powder into the inlet port of the elongate flow channel; vibrating the piezoelectric material with an electric excitation signal so that the piezoelectric material deflects upwardly; and flowing the dry powder out of the outlet port responsive to the vibrating step wherein the flowing step is carried out to serially dispense dose amounts of dry pharmaceutical powder(s), and wherein the flowing step is controllably started and stopped by the application and termination, respectively, of the electric excitation signal to the piezoelectric material.
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14. A method of dispensing a dry powder, comprising the steps of:
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providing an elongate flow channel having a powder support floor formed of a flexible piezoelectric material and inlet and outlet ports; tensioning the piezoelectric material in the flow channel; directing a quantity of dry powder into the inlet port of the elongate flow channel; vibrating the piezoelectric material with an electric excitation signal so that the piezoelectric material deflects upwardly; and flowing the dry powder out of the outlet port responsive to the vibrating step. - View Dependent Claims (15, 16)
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17. A method of dispensing a dry powder, comprising the steps of:
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providing an elongate flow channel having a powder support floor formed of a flexible piezoelectric material and inlet and outlet ports; directing a quantity of dry powder into the inlet port of the elongate flow channel; vibrating the piezoelectric material with an electric excitation signal so that the piezoelectric material deflects upwardly; and flowing the dry powder out of the outlet port responsive to the vibrating step wherein the excitation signal has a carrier frequency and a plurality of superpositioned modulating frequencies. - View Dependent Claims (18, 19, 20)
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21. A method for selecting and/or determining customizable excitation signals for dispensing dry powders, comprising the steps of:
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providing an elongate flow channel having a floor of piezoelectric material; selecting an angle of orientation for the flow channel such that at least a portion of the flow channel angularly extends in a non-vertical, non-horizontal orientation in the axial direction; providing a quantity of a target dry powder; outputting a vibration excitation signal having a first carrier frequency from a signal generator to the piezoelectric material; flowing the dry powder out of the flow channel; outputting a vibration excitation signal having a second carrier frequency from the signal generator to the piezoelectric material; and determining a dispensing vibration excitation signal for the target dry powder that generates a repeatable or a uniform or a repeatable and uniform fluid-like substantially non-agglomerated flow output based on flow data from the first and second vibration excitation signals, wherein the determined vibration excitation signal comprises a carrier frequency modulated by a plurality of modulating frequencies.
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22. A method for selecting and/or determining excitation signals suitable for fluidly dispensing dry powders, comprising the steps of:
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providing an elongate flow channel; providing a quantity of a target dry powder in the flow channel; vibrating the target dry powder in the flow channel with a first vibration excitation signal having a first carrier frequency and a first modulating frequency; flowing the dry powder out of the flow channel using the first vibration excitation signal; vibrating the target dry powder in the flow channel with a second vibration excitation signal different from the first vibration excitation signal, the second vibration excitation signal having a second carrier frequency and a second modulating frequency; flowing the target dry powder out of the flow channel using the second vibration excitation signal; and determining a dispensing vibration signal for the target dry powder that comprises a carrier frequency and at least one selected modulating frequency that generates at least one of a repeatable or uniform fluid-like substantially non-agglomerated flow output using flow data of the target dry powder derived from the first and second vibration excitation signals. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification