Device and method for loading hollow implantation needles with chains of radiation sources for interstitial brachytherapy of tissue

• US 7,118,523 B2
• Filed: 02/06/2003
• Issued: 10/10/2006
• Est. Priority Date: 02/06/2002
• Status: Active Grant

• Current Assignee: Eckert & Ziegler Bebig GmbH (Eckert & Ziegler Strahlen- und Medizintechnik AG)
• Original Assignee: Eckert & Ziegler Eurotope GmbH (Eckert & Ziegler AG)
• Inventors: Löffler, Edgar, Bornschein, Florian, Mondry, Günther, Müller, Andrcas
• Primary Examiner(s): Gilbert, Samuel G.
• Application Number:
  US10/359,547
• Publication Number:
  US 20040111004A1
• Time in Patent Office: 1,342 Days
• Field of Search: 600 1- 8, 600/439, 600/459, 600/585, 600/427, 600/407, 600/411, 250/370.11, 250/507.1, 601 2- 4, 604/22, 604 57- 61, 604/164.01, 376/158, 376/202, 424/1.29, 424/422, 534/697, 534/696.7 D, 251/124, 251/121, 976/DIG.350, 536696-700
• US Class Current: 600/3
• CPC Class Codes: A61N 2005/1009 Apparatus for loading seeds into magazines or needles
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 2005/1023 Means for creating a row of seeds, e.g. spacers
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

The invention relates to a device and a method for loading hollow implantation needles with radiation sources made of radiation source chains, and a radiation source chain for interstitial brachytherapy of tissue.

It is the object of the invention to develop a device and a method for packing and feeding of radiation sources made of radiation source chains as well as a radiation source chain for interstitial brachytherapy of tissue, whereby a precisely metered quantity of connected radiation sources (seeds) that has been predefined for implantation, and optionally of spacers, can be inserted without remnants into hollow needles located inside or all designed of tissue to be treated, by simple and reliable manipulation without manual intervention. The design safely guides the contiguous seeds through hollow needles with low-friction, reduces the risk of a malfunction and allows optimal cleaning and/or sterilization, while also reliably protecting the surroundings from radiation. The problem is solved, among others, by a device which has at least one supported, drivable cylindrical magazine (10) for winding the radiation source chain (1), at least one drive system for transporting the radiation source chain (1) from the magazine (10) into a guide system (12) and feeding the radiation source chain (1) into the tip of a hollow needle (19) coupled to the guide system (12). Also provided are a device (8) for separating/cutting the radiation source chain (1) at a defined location as well as a control device for preventing damage to the sheath of the radiation sources (seeds). All essential components of the device are surrounded by a radiation-absorbing housing.

Claims

1. Radiation source chain for injection into a hollow needle, comprising at least one modular radiation source and at least one modular bio-resorbable spacer, held together by a continuous bio-resorbable sheath surrounding said radiation source and said spacer, wherein the radiation source chain is flexible, an end face of the spacer and an end face of the radiation source directly contacting each other in at least one location on the source chain, such that the radiation source and the spacer are capable of bending with respect to each other at said location.

2. The radiation source chain according to claim 1, wherein

the spacer is elongated and has a diameter which is equal to at most the diameter of the radiation sources.

3. The radiation source chain according to claim 1,

wherein the diameter of the spacer at its center is smaller than the diameter at its ends, to thereby form a throat.

4. The radiation source chain according to claim 3, wherein

the spacer has a conical shape from either of its ends towards its center when in both a deployed and non-deployed state.

5. The radiation source chain according to claim 1, wherein

the spacer has a tubular shape.

6. The radiation source chain according to claim 1, wherein the spacer is hollow.

7. The radiation source chain according to claim 1, comprising at least two radiation sources, wherein the length of the spacer is sufficient to guarantee that the distance between successive radiation sources corresponds to a selected standard.

8. The radiation source chain according to claim 1, wherein end faces of the spacer have a concave shape, and end faces of the radiation source have a convex shape, the end faces of the spacer and the end faces of the radiation source directly contacting each other in at least one location on the source chain, such that the radiation source and the spacer are capable of bending with respect to each other at said location.

9. The radiation source chain according to claim 1, wherein end faces of the spacer have a convex shape, and end faces of the radiation source have a concave shape, the end faces of the spacer and the end faces of the radiation source directly contacting each other in at least one location on the source chain, such that the radiation source and the spacer are capable of bending with respect to each other at said location.

10. The radiation source chain according to claim 1, further comprising a means for allowing a position of the spacer or the radiation source within the chain to be unambiguously identified via visible markers on an outside surface of the sheath.

11. The radiation source chain according to claim 10, wherein the differentiating means comprises a marking or color on the sheath associated with one of the radiation source and spacer.

12. The radiation source chain according to claim 1, further comprising a means for allowing a position of the spacer or the radiation source within the chain to be unambiguously identified, wherein the means for allowing a position of the spacer or the radiation source within the chain to be unambiguously identified comprises a shape of the spacer contrasting to a shape of the radiation source.

13. The radiation source chain according to claim 1, wherein tha spacer comprises a region which is cuttable by a means for cutting, wherein said region is hollow and empty.

14. The radiation source chain according to claim 13, further comprising a means for allowing the region which is cuttable to be unambiguously identified via means for visibly identifying said region which is cuttable by way of visible information on an outside surface of the sheath.

15. The radiation source chain according to claim 13, wherein the region which is cuttable is formed so as to be cuttable by a force sufficient to cut through the spacer, but which force is not sufficient to damage the radiation source.

16. A spacer for use with radiation sources to form a radiation source chain, comprising

a discrete bio-resorbable spacer, wherein the spacer is elongated and has a throat when in both a deployed and non-deployed state with respect to a radiation source chain, the diameter of said throat being smaller than the diameter of said spacer at its ends around the whole circumference of the spacer, end faces of the spacer being structured to allow direct contact with respective end faces of a radiation source to thereby provide a direct contact location, and wherein the spacer has a conical shave from its ends towards its center when in both a deployed and non-deployed state.

17. The spacer of claim 16, wherein the diameter of said spacer is equal to at most the diameter of the radiation source.

18. The spacer of claim 16, wherein the spacer is solid.

19. The spacer of claim 16, wherein the spacer is hollow and inflexible.

20. The spacer of claim 16, for use with radiation sources having convex or concave end faces, wherein the spacer is provided with a corresponding concave or convex form on its end faces, such that the radiation source and the spacer are capable of bending with respect to each other at said direct contact location.

21. The spacer of claim 16, wherein the spacer is provided with a concave form on its end faces, such that the radiation source and the spacer are capable of bending with respect to each other at said direct contact location.

22. A spacer for use with radiation sources to form a radiation source chain, comprising a discrete bio-resorbable spacer, wherein the spacer is elongated and has a throat when in both a deployed and non-deployed state with respect to a radiation source chain, the diameter of said throat being smaller than the diameter of said spacer at its ends around the whole circumference of the spacer, end faces of the spacer being structured to allow direct contact with respective end faces of a radiation source to thereby provide a direct contact location, and wherein the spacer is used with radiation sources having convex or concave end faces, the spacer being provided with a corresponding concave or convex form on its end faces, such that the radiation source and the spacer are capable of bending with respect to each other at said direct contact location.

23. The spacer of claim 22, wherein the diameter of said spacer is equal to at most the diameter of the radiation source.

24. The spacer of claim 22, wherein the spacer is solid.

25. The spacer of claim 22, wherein the spacer is hollow and inflexible.

26. A spacer for use with radiation sources to form a radiation source chain, comprising a discrete bio-resorbable spacer, wherein the spacer is elongated and has a throat when in both a deployed and non-deployed state with respect to a radiation source chain, the diameter of said throat being smaller than the diameter of said spacer at its ends round the whole circumference of the spacer, end faces of the spacer being structured to allow direct contact with respective end faces of a radiation source to thereby provide a direct contact location, and wherein the spacer is provided with a concave form on its end faces, such that the radiation source and the spacer are capable of bending with respect to each other at said direct contact location.

27. The spacer of claim 26, wherein the diameter of said spacer is equal to at most the diameter of the radiation source.

28. The spacer of claim 26, wherein the spacer is solid.

29. The spacer of claim 26, wherein the spacer is hollow and inflexible.