Methods for monitoring and optimizing central venous pressure and intravascular volume

• US 7,118,534 B2
• Filed: 09/21/2001
• Issued: 10/10/2006
• Est. Priority Date: 09/21/2001
• Status: Active Grant

• Current Assignee: Virginia Commonwealth University
• Original Assignee: Virginia Commonwealth University
• Inventors: Arrowood, James A., Barbee, Robert W., Spiess, Bruce D., Ivatury, Rao R., Ward, Kevin R.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US10/380,347
• Publication Number:
  US 20040044290A1
• Time in Patent Office: 1,845 Days
• Field of Search: None
• US Class Current: 600/490
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

Central Venous Pressure (CVP) is non-invasively determined with accuracy comparable to invasive measurement techniques. To do so, curves are plotted based on non-invasively determined patient information obtained by applying a controllable variable (pressure) to a vein of interest at a non-distal point and taking certain measurements (such as pressure and volume measurements) from the patient. An example of a controllable variable is voltage applied in incremental inflation/deflation of a vascular cuff (1). A curve is plotted based on datapoints (such as a volume increase curve or a volume decline curve). Pertinent, accurate CVP and/or blood volume information is obtained from the slope of the non-invasive-based curve. Accurate CVP information is provided without the risks and disadvantages of invasive measurements.

Claims

1. A method for non-invasively determining and optimizing Central Venous Pressure (CVP) comprising the steps of:

applying a controllable pressure to a vein of interest at a non-distal point of a patient;

taking pressure and volume measurements from the patient to generate data points;

plotting intravascular measurements based on the data points as pressure and volume change curves;

determining from the pressure and volume and change curves an overall slope of the volume change curve and a maximum slope of the volume change curve; and

determining the CVP based on pressure at the volume change curve maximum slope.

2. The method of claim 1, including the step of absolutely determining central vascular pressure.

3. The method of claim 1, wherein the step of applying a controllable pressure includes inflating and/or deflating a vascular cuff surrounding an extremity upper part.

4. The method of claim 1, wherein the step of applying a controllable pressure includes inflating and/or deflating a vascular cuff surrounding an extremity upper part and further including the step of determining the rate of venous volume change upon deflation of said cuff.

5. The method of claim 1, wherein the step of applying a controllable pressure includes inflating and/or deflating a vascular cuff surrounding an extremity upper part and further including the step of determining the rate of venous volume change upon inflation of the vascular cuff.

6. The method of claim 1, wherein the step of applying a controllable pressure includes inflating and/or deflating a vascular cuff surrounding an extremity upper part and further including the step of determining the threshold of venous volume change upon deflation of the vascular cuff.

7. The method of claim 1, including the step of measuring pressure for a large vein.

8. The method of claim 1, wherein the step of including the step of wherein the step of applying a controllable pressure includes surrounding an upper extremity with an inflatable cuff, and where the method further includes making the volume and pressure measurements while inflating the cuff.

9. The method of claim 8, wherein the inflatable cuff is electrically and pneumatically connected to a programmed cuff inflator device.

10. The method of claim 9, wherein a computer processor receives pressure measurements from the inflatable cuff.

11. The method of claim 10, wherein a volume sensitive detector sends information to the computer processor via a signal amplifier.

12. The method of claim 1, further including the step of non-invasively detecting volume sensitive data for a distal part of an extremity by operating a volume sensitive detector selected from the group consisting of a mercury-in-silastic strain gauge, a bioimpedance device, a photo device, a plethysmography device, a laser Doppler device and a spectroscopic volume detection device.

13. The method of claim 1, wherein the steps of plotting intravascular measurements, determining an overall slope of the volume change curve and a maximum slope of the volume change curve and determining the CVP are performed by a computer system comprising an analogue-digital converter and a data acquisition system.

14. The method of claim 1, further including the step of determining whether intraabdominal pressure is elevated by determining pressure in large leg veins.

15. The method of claim 1, wherein the overall slope of the volume change curve is related to right ventricular compliance and venous return, which changes can be used to optimize a patient'"'"'s volume status.

16. The method of claim 1, wherein changes in the overall slope of the volume change curve are related to ventricular compliance and venous return, which changes can be used to optimize a patient'"'"'s volume status.

17. The method of claim 1, further including the steps of titrating fluid resuscitation and/or fluid therapy to maintain a CVP level, and titrating positive end-expiratory pressure (PEEP), to an effect on CVP to optimize both PEEP and CVP.

18. The method of claim 17, wherein fluid therapy titration based on a magnitude of non-invasively determined volume changes during deep inspiration.

19. The method of claim 1, further including the step of monitoring non-invasively determined central venous pressure along with non-invasive measures of cardiac output to indentify an optimized relationship between central venous pressure and cardiac output.

20. The method of claim 19, wherein the measure of cardiac output are selected from the group consisting of carbon dioxide rebreathing, Doppler, bioimpedance and arterial waveform analysis.

21. The method of claim 1, further including the step of:

monitoring non-invasive measures of extravascular lung water along with central venous pressure to differentiate lung injury from fluid excess and/or titrate fluid therapy, and/or differentiate total body fluid excess.

22. The method of claim 21, further including the step of applying a non-invasive measure of extravascular lung water or of extravascular water, selected from the group consisting of impedance cardiography (ICH) data and bioimpedance vector analysis (BIVA) data.

23. The method of claim 1, wherein the step of including the step of wherein the step of applying a controllable pressure includes placing an occluding cuff on an ankle and/or a wrist.

24. The method of claim 23, wherein pressure monitoring is provided by a sensor between the cuff and skin overlying the vessel being monitored.

25. A method of non-invasively determining Central Venous Pressure (CVP) comprising the steps of:

making an identified pressure measurement during a cuff inflation and/or deflation procedure; and

subtracting from the pressure measurement a baseline cuff pressure, to determine CVP according to CVP˜

P_{max slope}−

P₀, where P₀ is a measured initial pre-inflation pressure in an inflatable vascular cuff applied at a non-distal part of a patient and P_{max slope} is a measured pressure at a maximally sloping part of a curve consisting of data points (x,y), with x being a volume variable and y being time.

26. The method of claim 25, wherein variable x is controlled by using voltage used in inflating the vascular cuff.

27. The method of claim 25, including pressure monitoring by providing a sensor between the cuff and skin overlying a vessel being monitored.

28. A system for non-invasively determining Central Venous Pressure (CVP) comprising:

a inflatable cuff for applying a controllable pressure to a vein of interest at a non-distal point of a patient;

a data processing system;

a cuff inflator receiving control instructions from and sending pressure data to the data processing system, the cuff inflator controlling the inflatable cuff in response to control instructions from the data processing system;

a non-invasive volume sensitive detector attached to the patient and sending volume data to the data processing system, said volume data varying in response to pressure applied by the inflatable cuff;

said data processing system plotting intravascular measurements based on the data points as pressure and volume change curves, determining from the pressure and volume and change curves an overall slope of the volume change curve and a maximum slope of the volume change curve, and determining the CVP based on pressure at the volume change curve maximum slope.

29. The system of claim 28, wherein the inflatable cuff is sized for surrounding an extremity in an upper region.

30. The system of claim 28, wherein the data processing system comprises an analogue-digital converter and a data acquisition system.

31. The system of claim 28, further including at least one additional occluding cuff, the additional occluding cuff sized to an ankle and/or a wrist.

32. The system of claim 28, wherein the non-invasive volume sensitive detector is selected from the group consisting of a mercury-in-silastic strain gauge, a bioimpedance device, a photo device, a plethysmov..raphy device, a laser Doppler device and a spectroscopic volume detection device.

33. The system of claim 28, including a pressure monitoring sensor on the inflatable cuff and adapted to be placed between the inflatable cuff and skin overlying a vessel being monitored.