Method for producing a silver-containing wound care device

• US 7,118,761 B2
• Filed: 08/14/2003
• Issued: 10/10/2006
• Est. Priority Date: 08/14/2003
• Status: Active Grant

• Current Assignee: Milliken & Company
• Original Assignee: Milliken & Company
• Inventors: Canada, T. Andrew, Wiencek, Kenneth M., Kreider, Jason L., Sturm, Raymond C., Schuette, Robert L.
• Primary Examiner(s): Pak, John
• Application Number:
  US10/640,919
• Publication Number:
  US 20050037058A1
• Time in Patent Office: 1,153 Days
• Field of Search: 424/404, 424/409, 424/411, 424445-448, 424484-488, 424/604, 424/618, 424/DIG.13, 514/772.3, 514/772.6, 514/774, 514/779, 514/944, 514/945, 514/964, 514/965, 514/970, 442/123
• US Class Current: 424/445
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: Y10S 424/03 Hair bleach
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The finish may be applied to a target substrate, such as a fiber, fabric, film, foam, hydrogel, or hydrocolloid to provide a single layer antimicrobial wound care device. Alternatively, a silver-containing layer may be combined with one or more additional layers of target substrate to provide a composite antimicrobial wound care device. The device may also contain an odor-absorbing component capable of reducing or eliminating odors that are inherently associated with infectious wounds. Also provided is a method for making the wound care device and a composition of matter comprising the silver-based antimicrobial finish.

Claims

1. A process for producing a wound care device having a surface, at least a portion of which is coated with a non-electrically conductive finish,

wherein each coated wound care device exhibits a controlled silver-ion release rate of less than about 33 μ

g/cm² of silver ions over a 24 hour period, and wherein said finish exhibits antimicrobial properties;

said process comprising the steps of;

(a) providing said wound care device;

(b) providing said non-electrically conductive finish, wherein (1) said non-electrically conductive finish comprises silver zirconium phosphate, at least one binder material selected from the group consisting of polyurethane binders and acrylic binders, and at least one halide ion containing compound selected from the group consisting of metal halides and hydrohalic acids, (2) said finish is substantially free from alkali metal ions, and (3) molar ratio between the amount of halide ions available in said finish and the amount of silver ions available in said finish is 1;

10 to 5;

1; and

(c) applying said non-electrically conductive finish to at least a portion of said surface without causing discoloration of said surface, wherein said finish contains amounts of silver zirconium phosphate, said at least one binder material, and said at least one halide ion containing compound effective to exhibit a controlled silver-ion release that is antimicrobially effective and less than about 33 μ

g/cm² of silver ions over a 24 hour period.

2. The process of claim 1, wherein step (a) includes combining one or more layers of substrate together to provide said wound care device, wherein said substrate is selected from the group consisting of fabric, film, foam, alginate, hydrogel, and hydrocolloid.

3. The process of claim 2, wherein said one or more layers of substrate are combined using laminating or joining techniques selected from the group consisting of ultrasonic welding, heat or pressure lamination, the use of adhesives, needle punching, hydraulic needling, and sewing.

4. The process of claim 1, wherein an adhesive agent or layer is applied to the surface of said wound care device.

5. The process of claim 4, wherein a removable film is applied to said adhesive agent or layer on the surface of said wound care device.

6. A wound care device produced according to the process of claim 1.

7. A process for producing a wound care device having a surface, at least a portion of which is coated with a non-electrically conductive finish,

wherein each coated wound care device exhibits a controlled silver-ion release rate of less than about 25 μ

g/cm² of silver ions over a 24 hour period, and wherein said finish exhibits antimicrobial properties;

said process comprising the steps of;

(a) providing said wound care device;

(b) providing said non-electrically conductive finish, wherein (1) said non-electrically conductive finish comprises silver zirconium phosphate, at least one binder material selected from the group consisting of polyurethane binders and acrylic binders, and at least one halide ion containing compound selected from the group consisting of metal halides and hydrohalic acids, (2) said finish is substantially free from alkali metal ions, and (3) molar ratio between the amount of halide ions available in said finish and the amount of silver ions available in said finish is 1;

10 to 5;

1; and

(c) applying said non-electrically conductive finish to at least a portion of said surface without causing discoloration of said surface, wherein said finish contains amounts of silver zirconium phosphate, said at least one binder material, and said at least one halide ion containing compound effective to exhibit a controlled silver-ion release that is antimicrobially effective and less than about 25 μ

g/cm² of silver ions over a 24 hour period.

8. The process of claim 7, wherein step (a) includes combining one or more layers of substrate together to provide said wound care device, wherein said substrate is selected from the group consisting of fabric, film, foam, alginate, hydrogel, and hydrocolloid.

9. The process of claim 8, wherein said one or more layers of substrate are combined using laminating or joining techniques selected from the group consisting of ultrasonic welding, heat or pressure lamination, the use of adhesives, needle punching, hydraulic needling, and sewing.

10. The process of claim 7, wherein an adhesive agent or layer is applied to the surface of said wound care device.

11. The process of claim 10, wherein a removable film is applied to said adhesive agent or layer on the surface of said wound care device.

12. A wound care device produced according to the process of claim 7.

13. A process for producing a microdenier nonwoven wound care device having a surface, at least a portion of which is coated with a non-electrically conductive finish,

wherein each coated wound care device exhibits a controlled silver-ion release rate of less than about 10 μ

g/cm² of silver ions over a 24 hour period, and wherein said finish exhibits antimicrobial properties;

said process comprising the steps of;

(a) providing said wound care device;

(b) providing said non-electrically conductive finish, wherein (1) said non-electrically conductive finish comprises silver zirconium phosphate, at least one binder material selected from the group consisting of polyurethane binders and acrylic binders, and at least one halide ion containing compound selected from the group consisting of metal halides and hydrohalic acids, (2) said finish is substantially free from alkali metal ions, and (3) molar ratio between the amount of halide ions available in said finish and the amount of silver ions available in said finish is 1;

10 to 5;

1; and

(c) applying said non-electrically conductive finish to at least a portion of said surface without causing discoloration of said surface, wherein said finish contains amounts of silver zirconium phosphate, said at least one binder material, and said at least one halide ion containing compound effective to exhibit a controlled silver-ion release that is antimicrobially effective and less than about 10 μ

g/cm² of silver ions over a 24 hour period.

14. The process of claim 13, wherein step (a) includes combining one or more layers of substrate together to provide said wound care device, wherein said substrate is selected from the group consisting of fabric, film, foam, alginate, hydrogel, and hydrocolloid.

15. The process of claim 14, wherein said one or more layers of substrate are combined using laminating or joining techniques selected from the group consisting of ultrasonic welding, heat or pressure lamination, the use of adhesives, needle punching, hydraulic needling, and sewing.

16. The process of claim 13, wherein an adhesive agent or layer is applied to the surface of said wound care device.

17. The process of claim 16, wherein a removable film is applied to said adhesive agent or layer on the surface of said wound care device.

18. A wound care device produced according to the process of claim 13.