Diffraction-based diagnostic devices
First Claim
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1. A method of making a biosensor, comprising the steps of:
- forming a receptive material layer generally uniformly over a surface of a substrate member, the layer containing a receptive material specific for an analyte of interest;
defining at least one active area and at least one inactive area of the receptive material in a masking process wherein a blocking agent is used to render the receptive material inactive in the defined inactive area; and
wherein when the biosensor is exposed to a medium containing the analyte of interest, the analyte binds to the receptive material in the active areas and facilitates subsequent diffraction of transmitted light or reflected light in a diffraction pattern corresponding to the active areas.
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Abstract
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process.
193 Citations
17 Claims
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1. A method of making a biosensor, comprising the steps of:
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forming a receptive material layer generally uniformly over a surface of a substrate member, the layer containing a receptive material specific for an analyte of interest; defining at least one active area and at least one inactive area of the receptive material in a masking process wherein a blocking agent is used to render the receptive material inactive in the defined inactive area; and wherein when the biosensor is exposed to a medium containing the analyte of interest, the analyte binds to the receptive material in the active areas and facilitates subsequent diffraction of transmitted light or reflected light in a diffraction pattern corresponding to the active areas. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification