Probe and apparatus for measuring cerebral hemodynamics and oxygenation

• US 7,120,481 B2
• Filed: 07/19/2001
• Issued: 10/10/2006
• Est. Priority Date: 07/21/2000
• Status: Expired due to Term

• Current Assignee: Universität Zürich
• Original Assignee: Universität Zürich
• Inventors: Niederer, Peter, Nadler, Andreas, Keller, Emmaneula
• Primary Examiner(s): Winakur, Eric F.
• Application Number:
  US10/333,262
• Publication Number:
  US 20040039270A1
• Time in Patent Office: 1,909 Days
• Field of Search: 600/310, 600322-325, 600/337, 600/339
• US Class Current: 600/339
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/6864 Burr holes

Abstract

A probe and an apparatus for cerebral diagnostics and therapy, in particular for measuring absolute values of regional cerebral flow (CBF) and cerebral oxygenation. The probe is inserted through a burr hole in the skull and comprises illuminating device, light receiving device and a coating encapsulating said illuminating device and said light receiving means. The coating has a longitudinal shape and is adapted to fit through a burr hole in the skull. The coating is further adapted to slide between the skull and the dura, to be inserted into the ventricular system, and/or to be inserted into the cerebral tissue.

Claims

1. A probe for cerebral diagnostics and/or therapy, in particular for measuring characteristics of cerebral hemodynamics and oxygenation by optical reflectance, comprising

illuminating means comprising first optical transmission means including at least one first optical fiber, and first deflection means coupled to the first optical transmission means for deflection of transmitted light into a direction other than the direction of light transmission within the first optical transmission means;

light receiving means comprising second optical transmission means including at least one second optical fiber, and second deflection means coupled to the second optical transmission means for deflection of light into the second optical transmission means, the light coming from a direction other than the direction of light transmission within the second optical transmission means, wherein the first and second deflection means are located at a distance (D1) from each other of 20 to 50 mm;

a coating encapsulating said illuminating means and said light receiving means, said coating having a longitudinal shape and being adapted to fit through a burr hole in the skull, said coating further being adapted to at least one of the following;

sliding between the skull and the dura, being inserted into the ventricular system, being inserted into the cerebral tissue.

2. The probe according to claim 1, wherein the coating is made of silicone rubber or polyurethane.

3. The probe according to claim 1, having a width (W) less than about 20 mm, and a thickness (T) less than about 5 mm.

4. The probe according to claim 1, further comprising a pressure sensor and signal transfer means connected to said pressure sensor for transmitting signals containing pressure information.

5. The probe according to claim 1, further comprising means for the transfer and release of a substance into the cerebral tissue and/or into the ventricular system.

6. The probe according to claim 1, wherein the first and second deflection means deflect light into/from a direction (B) substantially vertical to the direction (A) of light propagation in the transmission means.

7. The probe according to claim 1, wherein the distance (D1) between the first and second deflection means is 30 to 40 mm.

8. The probe according to claim 1, wherein the first and second deflection means include a mirror oriented at approximately 45°

with respect to the direction of the first and second optical transmission means.

9. The probe according to claim 8, wherein the mirror is a prison.

10. The probe according to claim 1, wherein the face of the at least one first or second fiber at the distal end of the first and second transmission means is oriented at approximately 45°

with respect to the direction of light propagation (A) within the first respectively second optical transmission means.

11. The probe according to claim 1, wherein the first and second optical transmission means each include a plurality of first and second optical fibers, the fibers being arranged in a common plane.

12. The probe according to claim 1, wherein the coating includes an optical window in the region of the first and second deflection means.

13. The probe according to claim 1, wherein the first and second optical fibers are suited to transmit light within the near infrared region of 700 to 1300 nm spectral range.

14. The probe according to claim 1, having a width (W) less than about 10 mm, and a thickness (T) less than about 2 mm.

15. The probe according to claim 1, wherein the first and second optical fibers are suited to transmit light within the near infrared region of 750 to 950 nm spectral range.

16. A probe for cerebral diagnostics and/or therapy, in particular for measuring characteristics of cerebral hemodynamics and oxygenation by optical reflectance, comprising

illuminating means comprising at least one light emitting device (102);

light receiving means comprising at least one light detecting device (106);

wherein the illuminating means and the light receiving means are located at a distance (D1) from each other of 20 to 50 mm;

a coating encapsulating said illuminating means and said light receiving means, said coating having a longitudinal shape and being adapted to fit through a burr hole in the skull, said coating further being adapted to at least one of the following;

sliding between the skull and the dura, being inserted into the ventricular system, being inserted into the cerebral tissue.

17. Probe according to claim 16, wherein the light emitting device is powered via first electric wiring and the light detecting device generates an electric signal transmitted via a second electric wiring.

18. The probe according to claim 16, wherein the light emitting device comprises a light emitting diode (LED) or a diode laser.

19. The probe according to claim 18, wherein the light emitting device emits a light in the near infrared region of 700 to 1300 nm spectral range, and the light detecting device comprises a receiver diode.

20. The probe according to claim 16, wherein the illuminating means comprise a plurality of light emitting devices.

21. The probe according to claim 16, wherein the coating is made of silicone rubber or polyurethane.

22. The probe according to claim 16, having a width (W) less than about 20 mm and a thickness (T) less than about 5 mm.

23. The probe according to claim 16, having a width (W) of 5 to 10 mm, and a thickness (T) of about 2 mm.

24. The probe according to claim 16, further comprising a pressure sensor and signal transfer means connected to it for transmitting signals containing pressure information.

25. The probe according to claim 16, further comprising means for the transfer and release of a substance into the cerebral tissue and/or into the ventricular system.

26. The probe according to claim 16, wherein the illuminating means and the light receiving means are located at a distance (D1) from each other of 30 to 40 mm.

27. The probe according to claim 16, wherein the coating includes an optical window.

28. The probe according to claim 16, wherein the light emitting device is capable of emitting at wavelengths at about 782 nm, 857 nm and 908 nm.