Method and apparatus for determining alveolar opening and closing

• US 7,122,010 B2
• Filed: 05/01/2003
• Issued: 10/17/2006
• Est. Priority Date: 12/10/1998
• Status: Expired due to Term

• Current Assignee: Timpel Medical B.V.
• Original Assignee: Marcelo B.P. Amato, Stephan Bohm
• Inventors: Böhm, Stephan, Amato, Marcelo B. P., Kunst, Peter W. A.
• Primary Examiner(s): Hayes, Michael J.
• Assistant Examiner(s): Mendoza, Michael G.
• Application Number:
  US10/426,961
• Publication Number:
  US 20040073130A1
• Time in Patent Office: 1,265 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.23, 128/204.26, 600/413, 600/533, 600/534, 600/536
• US Class Current: 600/536
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity

Abstract

The invention refers to a method for the regional determination of the alveolar opening and alveolar closing of the lung depending on the respiration pressure, wherein according to the method of electrical impedance tomography, an impedance signal is measured in at least one lung zone depending on the respiration pressure. The alveolar opening or closing of a lung zone is determined, in particular to enable an improved artificial respiration.

Claims

1. Method for determining the alveolar opening and/or alveolar closing of a lung, comprising the steps of:

ventilating the lung with an artificial ventilator with inspiratory and expiratory airway pressures,

measuring according to a method of electrical impedance tomography an impedance signal in a lung zone, and

changing at least one of the inspiratory and expiratory airway pressures, and

generating a curve from the measuring step,

wherein from an observation of the curve of the measured impedance signal a first respiration pressure value is determined at which alveolar closing in said lung zone occurs and/or a second respiration pressure value is determined at which alveolar opening in said lung zone occurs.

2. Method according to claim 1, wherein a first respiration pressure value which corresponds to the alveolar closing of said lung zone is determined as soon as a mean change in the impedance signal based on breathing movements (A₁, A₂, A₁′

, A₂′

) falls below a first breathing movement comparative value and wherein a second respiration pressure value which corresponds to the alveolar opening of said lung zone is determined as soon as the mean change in the impedance signal due to breathing movements (A₁, A₂, A₁′

, A₂′

) moves above a second breathing movement comparative value.

3. Method according to claim 2, wherein based on an expiratory airway pressure with which the lung alveoli are almost open in said lung zone, the expiratory airway pressure is reduced step by step until alveolar closing is determined in said lung zone and wherein based on an expiratory airway pressure with which the alveolar closing was determined, the inspiratory airway pressure is suddenly increased until alveolar opening is determined in said lung zone.

4. Method according to claim 2, wherein the mean change of the impedance signal due to breathing movements (A₁, A₂, A₁′

, A₂′

) is determined based on an averaged mean square root of the impedance signal over a plurality of inspirations.

5. Method according to claim 2, wherein the mean change in the impedance signal due to breathing movements is determined on the basis of an average peak to peak value of the impedance signal over a plurality of inspirations.

6. Method according to claim 2, wherein the first breathing movement comparative value and/or the second breathing movement comparative value are predetermined.

7. Method according to claim 2, wherein the first breathing movement comparative value and/or the second breathing movement comparative value are determined dynamically from the mean change in the impedance signal due to breathing movements in a different lung zone.

8. Method according to claim 7, wherein the different lung zone is a zone which is above the lung zone concerned in the direction of a gravity vector.

9. Method according to claim 1, wherein a first respiration pressure value which corresponds to the alveolar closing of said lung zone is determined as soon as an average change in the impedance signal due to the collapse of the alveoli (B, B′

) falls below a collapse comparative value and wherein a second respiration pressure value which corresponds to the alveolar opening of said lung zone which corresponds to the alveolar opening of said lung zone is determined as soon as the average change in the impedance signal due to the opening of the alveoli (B, B′

) moves above an opening comparative value.

10. Method according to claim 9, wherein based on an expiratory airway pressure with which the lung alveoli are almost open in said lung zone, the expiratory airway pressure is reduced step by step until alveolar closing is determined in said lung zone and wherein based on an expiratory airway pressure with which the alveolar closing was determined, the inspiratory airway pressure is suddenly increased until alveolar opening is determined in said lung zone.

11. Method according to claim 9, wherein the average change in the impedance signal due to the collapse or opening of the alveoli (B, B′

) is determined on the basis of an average gradient of the impedance signal depending on the inspiratory and expiratory airway pressures.

12. Method according to claim 9, wherein the average change in the impedance signal due to the collapse/opening of the alveoli (B, B′

) is determined on the basis of a straight line adaptation according to the Gauβ

compensation calculation.

13. Method according to claim 9, wherein the collapse comparative value and/or the opening comparative value are predetermined.

14. Method according to claim 9, wherein the collapse comparative value and/or the opening comparative value are determined dynamically from the average change in the impedance signal due to the collapse of the alveoli in another lung zone.

15. Method according to claim 14, wherein the another lung zone is a zone which is above the lung zone concerned in the direction of a gravity vector.

16. Method according to claim 1, wherein a first respiration pressure value which corresponds to the alveolar closing of said lung zone is determined as soon as an average response delay in the impedance signal due to respiration pressure changes (C, C′

) moves above a first respiration comparative value and wherein a second respiration pressure value which corresponds to the alveolar opening of said lung zone is determined as soon as the average response delay in the impedance signal due to respiration pressure changes (C, C′

) falls below a second respiration comparative value.

17. Method according to claim 16, wherein based on an expiratory airway pressure with which the lung alveoli are almost closed in said lung zone, the inspiratory airway pressure is pulse-shaped increased until alveolar opening is determined in said lung zone.

18. Method according to claim 16, wherein the average response delay due to respiration pressure changes (C, C′

) is determined on the basis of an average initial gradient with which the impedance signal follows a change in inspiratory airway pressure.

19. Method according to claim 16, wherein the average response delay due to respiration pressure changes (C, C′

) is determined on the basis of a time constant with which the impedance signal follows a change in inspiratory airway pressure.

20. Method according to claim 16, wherein the first respiration comparative value and/or the second respiration comparative value are prescribed.

21. Method according to claim 16, wherein the first respiration comparative value and/or the second respiration comparative value are determined dynamically from the average response delay in the impedance signal due to a change of the inspiratory airway pressure in another lung zone.

22. Method according to claim 21, wherein the another lung zone is a zone which is above the lung zone concerned in the direction of a gravity vector.

23. Method according to claim 1, wherein the lung is subdivided into a plurality of zone planes in the direction of a gravity vector.

24. Method according to claim 1, wherein the lung is divided into a plurality of radial sectors, wherein a centre point axis of the sectors is located in the direction of a gravity vector.