Intra-aortic renal drug delivery catheter
First Claim
1. A method of controlling blood flow to a plurality of renal arteries via their respective renal ostia at unique relative locations along an abdominal aorta in a patient, comprising:
- a) providing a catheter comprising i) an elongated shaft with a proximal end portion and a distal end portion that is adapted to be positioned at a location within the abdominal aorta associated with the renal ostia;
ii) a tubular member on the distal end portion having an interior passageway which is radially expandable within the abdominal aorta at the location, and which is configured to extend within the abdominal aorta upstream and downstream of the renal ostia; and
iii) a radially expandable member on the tubular member, having an expanded configuration with an outer diameter larger than an outer diameter of the tubular member and which is configured to decrease the blood flow in the outer blood flow stream downstream of the renal ostia;
b) advancing the distal end portion to the location within the patient'"'"'s abdominal aorta, so that an upstream end of the tubular member is upstream of the renal ostia and the radially expandable member is downstream of the renal ostia;
c) expanding the tubular member to separate blood flow through the abdominal aorta into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member; and
d) expanding the radially expandable member to the expanded configuration to thereby decrease the blood flow in the outer blood flow stream downstream of the renal ostia.
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Accused Products
Abstract
A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member. The radially expandable member is located down-stream of the shaft agent delivery port, and has an expanded configuration with an outer diameter larger than an outer diameter of the tubular member. The expanded radially expandable member is configured to decrease the blood flow in the outer blood flow stream down-stream of the branch vessel. The catheter provides for delivery of an agent to a branch vessel of a major vessel, and continuous perfusion of the major blood vessel. Another aspect of the invention is directed to methods of delivering a therapeutic or diagnostic agent to one or both kidney'"'"'s of a patient.
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Citations
14 Claims
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1. A method of controlling blood flow to a plurality of renal arteries via their respective renal ostia at unique relative locations along an abdominal aorta in a patient, comprising:
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a) providing a catheter comprising i) an elongated shaft with a proximal end portion and a distal end portion that is adapted to be positioned at a location within the abdominal aorta associated with the renal ostia;
ii) a tubular member on the distal end portion having an interior passageway which is radially expandable within the abdominal aorta at the location, and which is configured to extend within the abdominal aorta upstream and downstream of the renal ostia; and
iii) a radially expandable member on the tubular member, having an expanded configuration with an outer diameter larger than an outer diameter of the tubular member and which is configured to decrease the blood flow in the outer blood flow stream downstream of the renal ostia;
b) advancing the distal end portion to the location within the patient'"'"'s abdominal aorta, so that an upstream end of the tubular member is upstream of the renal ostia and the radially expandable member is downstream of the renal ostia;
c) expanding the tubular member to separate blood flow through the abdominal aorta into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member; and
d) expanding the radially expandable member to the expanded configuration to thereby decrease the blood flow in the outer blood flow stream downstream of the renal ostia. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification