Polyanhydrides with therapeutically useful degradation products
First Claim
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1. An aromatic polyanhydride comprising a repeating unit having the structure:
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Abstract
An aromatic polyanhydride having a repeating unit with structure (I) wherein Ar is a substituted or unsubstituted aromatic ring and R is a difunctional organic moiety substituted on each Ar ortho to the anhydride group. Ortho-substituted bis-aromatic dicarboxylic acid anhydride monomers and ortho-substituted bis-aromatic dicarboxylic acid intermediates thereof are also disclosed, as well as implantable medical devices, such as scaffolding implants for tissue reconstruction, drug delivery systems prepared from the aromatic polyanhydrides, as well as therapeutic oral dosage forms and treatment methods.
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42 Claims
- 1. An aromatic polyanhydride comprising a repeating unit having the structure:
- 16. An ortho-substituted bis-aromatic dicarboxylic acid anhydride having the structure:
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20. An ortho-substituted bis-aromatic dicarboxylic acid having the structure HOOC—
- Ar—
R—
Ar—
COOH, wherein Ar is an aromatic ring;
R is —
Z1—
R1—
Z1—
substituted on each Ar ortho to the anhydride group;
R1 is a difunctional organic moiety;
Z1 is a difunctional moiety selected from the group consisting of ester, amides, urethanes, carbamates and carbonates; and
Ar and R are selected so that when the ortho-substituted bis-aromatic dicarboxylic acid anhydride hydrolyzes, a therapeutic salicylate, another non-steroidal anti-inflammatory, an antifibrotic aminobenzoate, or a vasoconstricting phenylethanolamine is formed. - View Dependent Claims (21, 22, 23)
- Ar—
Specification