Method and system for evaluating arrhythmia risk with QT-RR interval data sets
First Claim
1. A method of screening for risk of cardiac arrhythmia in a subject, the method comprising the steps of:
- (a) collecting at least one QT interval data set and at least one RR interval data set from the subject during (i) a stage of gradually increasing heart rate, (ii) a stage of gradually decreasing heart rate, or (iii) both a stage of gradually increasing heart rate and gradually decreasing heart rate;
(b) separating fluctuations from slow trends in said at least one QT interval data set and in said at least one RR interval data set to provide QT fluctuations and RR fluctuations;
(c) comparing said QT fluctuations and said RR fluctuations to one another to determine the difference therebetween; and
(d) generating from the comparison of step (c) a measure of risk of cardiac arrhythmia in said subject, wherein a greater difference between QT fluctuations and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject.
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Abstract
A method of assessing the cardiac arrhythmia risk in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. In one embodiment, the method comprises the steps of: (a) collecting at least one QT and RR interval data set from the subject; (b) separating fluctuations from slow trends in said at least one QT and RR interval data set; (c) comparing said QT and RR fluctuations to one another and (d) generating from the comparison of step (c) partial measures of risk of cardiac arrhythmia in said subject. A greater difference between QT and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject. The data sets are collected in such a manner that they reflect almost exclusively the conduction in the heart muscle and minimize the effect on the data sets of rapid transients due to autonomic nervous system and hormonal control.
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Citations
17 Claims
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1. A method of screening for risk of cardiac arrhythmia in a subject, the method comprising the steps of:
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(a) collecting at least one QT interval data set and at least one RR interval data set from the subject during (i) a stage of gradually increasing heart rate, (ii) a stage of gradually decreasing heart rate, or (iii) both a stage of gradually increasing heart rate and gradually decreasing heart rate; (b) separating fluctuations from slow trends in said at least one QT interval data set and in said at least one RR interval data set to provide QT fluctuations and RR fluctuations; (c) comparing said QT fluctuations and said RR fluctuations to one another to determine the difference therebetween; and (d) generating from the comparison of step (c) a measure of risk of cardiac arrhythmia in said subject, wherein a greater difference between QT fluctuations and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of assessing risk of cardiac arrhythmia in a subject, said method comprising the steps, performed on a computer system, of:
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(a) providing at least one QT interval data set and at least one RR interval data set collected from said subject during (i) a stage of gradually increasing heart rate, (ii) a stage of gradually decreasing heart rate, or (iii) both a stage of gradually increasing heart rate and gradually decreasing heart rate; (b) separating fluctuations from slow trends in said at least one QT interval data set and in said at least one RR interval data set to provide QT fluctuations and RR fluctuations; (c) comparing said QT fluctuations and said RR fluctuations to one another to determine the difference therebetween; and (d) generating from the comparison of step (c) a measure of risk of cardiac arrhythmia in said subject, wherein a greater difference between QT fluctuations and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject.
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Specification