Stimulation of autonomic nerves

• US 7,123,961 B1
• Filed: 05/07/2004
• Issued: 10/17/2006
• Est. Priority Date: 06/13/2002
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Kroll, Mark W., Bornzin, Gene A.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US10/841,094
• Time in Patent Office: 893 Days
• Field of Search: 607/2, 607/9, 607/11, 607/17, 607/25, 607/28, 607/118
• US Class Current: 607/9
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

An exemplary method for stimulating an autonomic nerve that includes delivering power to, for example, an electrode at a set power level, determining whether the delivering achieved an autonomic response that affected cardiac function, and delivering power to the electrode at a reduced power level if the delivering affected the cardiac function. An exemplary device for performing such an exemplary method. Other exemplary methods and exemplary devices are also disclosed.

Claims

1. A method for delivering power to an electrode for stimulating an autonomic nerve to affect heart activity, comprising:

delivering power to the electrode at a power level;

determining whether the delivering achieved an autonomic response that affected cardiac contractility; and

delivering power to the electrode at a reduced power level if the delivering achieved an autonomic response that affected the cardiac contractility.

2. The method of claim 1, wherein the power level comprises a maximum power level based at least in part on power limitations of an implantable device.

3. The method of claim 1, wherein the power level comprises a maximum power level based at least in part on battery life of an implantable device.

4. The method of claim 1, wherein the autonomic nerve is a parasympathetic nerve.

5. The method of claim 4, wherein the determining determines whether the delivering decreased heart rate.

6. The method of claim 4, wherein the determining determines whether the delivering decreased dromotropy.

7. The method of claim 4, wherein the determining determines whether the delivering decreased inotropy.

8. The method of claim 1, wherein the autonomic nerve is a sympathetic nerve.

9. The method of claim 8, wherein the determining determines whether the delivering increased heart rate.

10. The method of claim 8, wherein the determining determines whether the delivering increased inotropy.

11. The method of claim 8, wherein the determining determines whether the delivering increased dromotropy.

12. The method of claim 1, wherein the reduced power level is determined by reducing a parameter and wherein the parameter comprises at least one parameter selected from the group consisting of amplitude, frequency, voltage, current, energy, charge, power, number of pulses and pulse width.

13. The method of claim 1, wherein the determining determines whether the delivering caused an undesirable evoked response.

14. One or more computer-readable media having computer-readable instructions thereon which, when executed by a programmable stimulation device, causes a stimulation device to deliver power to an electrode for stimulating an autonomic nerve to affect heart activity, said instructions including code for:

delivering power to the electrode at a power level;

determining whether the delivering achieved an autonomic response that affected cardiac contractility; and

delivering power to the electrode at a reduced power level if the delivering achieved an autonomic response that affected the cardiac contractility.

15. A method for delivering power to an electrode for stimulating an autonomic nerve to affect cardiac function, comprising:

delivering power to the electrode at a pulse width and at a frequency;

determining whether the delivering caused an undesirable evoked response; and

delivering power to the electrode at a reduced pulse width and at an increased frequency if the delivering caused an undesirable evoked response.

16. The method of claim 15, wherein the delivering at a pulse width and at a frequency and the delivering at a reduced pulse width and at an increased frequency both deliver approximately the same power.

17. The method of claim 15, wherein the determining further comprises determining whether the delivering affected chronotropy, inotropy, and/or dromotropy.

18. The method of claim 15, wherein the delivering further comprising reducing the power to the electrode if the delivering affected chronotropy, inotropy, and/or dromotropy.

19. One or more computer-readable media having computer-readable instructions thereon which, when executed by a programmable stimulation device, causes a stimulation device to deliver power to an electrode for stimulating an autonomic nerve to affect cardiac function, said instructions including code for:

delivering power to the electrode at a pulse width and a frequency;

determining whether the delivering caused an undesirable evoked response; and

delivering power to the electrode at a reduced pulse width and at an increased frequency if the delivering caused an undesirable evoked response.

20. An implantable stimulation device for stimulating an autonomic nerve to affect cardiac function, comprising:

an electrode configured to deliver a stimulation pulse to an autonomic nerve at a power level;

a sensor configured to acquire data on cardiac contractility in response to the stimulation pulse;

a controller configured to reduce the power level to a reduced power level if the cardiac contractility changed in response to the stimulation pulse.

21. The device of claim 20, wherein the power level is a maximum power level.

22. The device of claim 21, wherein the maximum power is based at least in part on power supply life.

23. The device of claim 20, wherein the stimulation pulse comprises an amplitude, a frequency, and a pulse width.

24. The device of claim 23, wherein the controller is further configured to increase the frequency of the stimulation pulse and to decrease the pulse width of the stimulation pulse if the stimulation pulse caused an undesirable evoked response.

25. The device of claim 20 wherein the device comprises a pressure sensor adapted to sense pressure in a right ventricle and to generate an electrical pressure signal corresponding to the sensed pressure.

26. A method for positioning an electrode comprising:

delivering power to the electrode at a power level;

determining whether the delivering affected cardiac function due to stimulation of an autonomic nerve; and

repositioning the electrode if the delivering did not affect the cardiac function or delivering power to the electrode at a reduced power level if the delivering affected the cardiac function.

27. A method for selecting an electrode comprising:

delivering power to the electrode at a power level;

determining whether the delivering affected cardiac function due to stimulation of an autonomic nerve; and

selecting another electrode if the delivering did not affect the cardiac function or delivering power to the electrode at a reduced power level if the delivering affected the cardiac function.

28. An implantable stimulation device for stimulating an autonomic nerve to affect cardiac function, comprising:

electrode means for delivering a stimulation pulse to an autonomic nerve at a maximum power level based at least in part on power limitations or battery life of the implantable stimulation device;

sensor means for acquiring data on cardiac function in response to the stimulation pulse;

controller means for reducing the power level to a reduced power level if the cardiac function changed in response to the stimulation pulse.

29. The implantable stimulation device of claim 28, wherein the autonomic nerve is a parasympathetic nerve.

30. The implantable stimulation device of claim 29, wherein the determining determines whether the delivering decreased heart rate.

31. The implantable stimulation device of claim 29, wherein the determining determines whether the delivering decreased dromotropy.

32. The implantable stimulation device of claim 29, wherein the determining determines whether the delivering decreased inotropy.

33. The implantable stimulation device of claim 28, wherein the autonomic nerve is a sympathetic nerve.

34. The implantable stimulation device of claim 33, wherein the determining determines whether the delivering increased heart rate.

35. The implantable stimulation device of claim 33, wherein the determining determines whether the delivering increased inotropy.

36. The implantable stimulation device of claim 33, wherein the determining determines whether the delivering increased dromotropy.