Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
First Claim
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1. A substantially purified single or two chain MTSP7 protease that comprises the sequence of amino acids encoded by the sequence of nucleotides set forth in SEQ ID No. 15.
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Abstract
Provided herein are type II transmembrane serine protease 7 (MTSP7) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP7 are provided.
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36 Claims
- 1. A substantially purified single or two chain MTSP7 protease that comprises the sequence of amino acids encoded by the sequence of nucleotides set forth in SEQ ID No. 15.
- 3. A substantially purified two chain protease comprising the MTSP7 protease domain encoded by the sequence of nucleotides set forth in SEQ ID No. 17.
- 4. A substantially purified single chain or two chain protease that consists of the MTSP7 protease domain encoded by the sequence of nucleotides set forth in SEQ ID No. 17.
- 7. A modified single or two chain MTSP7 protease wherein the protease comprises the sequence of amino acids encoded by the sequence of nucleotides set forth in SEQ ID No. 15 modified by the replacement of a free Cysteine in the protease domain with another amino acid.
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9. A modified protease, comprising the sequence of amino acids set forth between positions 206–
- 438 of SEQ ID No. 16 modified by the replacement of a free cysteine with a serine.
- View Dependent Claims (10, 15, 16, 27, 28)
Specification