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Derivatized oligonucleotides having improved uptake and other properties

  • US 7,125,975 B2
  • Filed: 01/09/2004
  • Issued: 10/24/2006
  • Est. Priority Date: 10/24/1991
  • Status: Expired due to Fees
First Claim
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1. A compound comprising a plurality of linked nucleosides, wherein:

  • at least one of the nucleosides is a 2′

    -deoxy′

    -2′

    -fluoro, 2′

    -O—

    C1

    C20-alkyl, 2′

    -O—

    C2

    C20-alkenyl, 2′

    -O—

    C2

    C20-alkynyl, 2′

    -S—

    C1

    C20-alkyl, 2′

    -S—

    C2

    C20-alkenyl, 2′

    -S—

    C2

    C20-alkynyl, 2′

    -NH—

    C1

    C20-alkyl, 2′

    -NH—

    C2

    C20-alkenyl, or 2′

    -NH—

    C2

    C20-alkynyl nucleoside; and

    at least one of the nucleosides is a 5′

    -O-terminal nucleoside having a non-aromatic lipophilic molecule linked to the 5′

    -O-position of the nucleoside, provided that the compound does not include sulfamate or sulfamide internucleotide linkages.

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