Device and method for pressure-driven plug transport and reaction
DC CAFCFirst Claim
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1. A method of conducting a reaction within at least one plug comprising the steps of:
- introducing a carrier-fluid into a first microchannel of a device;
simultaneously introducing at least two streams of plug-fluids into a first inlet in fluid communication with the first microchannel so that at least one plug forms in the carrier-fluid after the streams contact the carrier-fluid;
wherein;
a first plug-fluid comprises a first reagent;
a second plug-fluid comprises a second reagent;
each plug-fluid is immiscible with the carrier-fluid; and
each plug comprises both the first and second plug-fluids so that the reaction of the reagents substantially occurs in the plug;
each plug is substantially surrounded by carrier.
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Abstract
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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Citations
32 Claims
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1. A method of conducting a reaction within at least one plug comprising the steps of:
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introducing a carrier-fluid into a first microchannel of a device; simultaneously introducing at least two streams of plug-fluids into a first inlet in fluid communication with the first microchannel so that at least one plug forms in the carrier-fluid after the streams contact the carrier-fluid;
wherein;a first plug-fluid comprises a first reagent; a second plug-fluid comprises a second reagent; each plug-fluid is immiscible with the carrier-fluid; and each plug comprises both the first and second plug-fluids so that the reaction of the reagents substantially occurs in the plug; each plug is substantially surrounded by carrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification