Method and apparatus for improving ventricular status using the force interval relationship

• US 7,130,684 B2
• Filed: 04/30/2003
• Issued: 10/31/2006
• Est. Priority Date: 04/30/2003
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Mulligan, Lawrence J., Burnes, John E., Hill, Michael R. S.
• Primary Examiner(s): Pezzuto, Robert
• Assistant Examiner(s): LEE, YUN HAENG NMN
• Application Number:
  US10/426,730
• Publication Number:
  US 20040220639A1
• Time in Patent Office: 1,280 Days
• Field of Search: 607 1- 3, 607/9, 607/17, 607/23, 607/24, 607/27, 607/62, 600508-510, 600/526, 600/587
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

Methods and devices for improving ventricular contractile status of a patient suitably exploit changes in ventricular pressure and/or dP/dt_max to provide and/or optimize a response to a patient. The ventricular pressure may be appropriately correlated to intracellular calcium regulation, which is indicative of contractile status. To assess ventricular contractile status, the device suitably observes a cardiac perturbation of the patient and measures force interval potentiation following the perturbation. The contractile potentiation can then be stored and/or quantified in the implantable medical device to determine the ventricular contractile status of the patient, and an appropriate response may be provided to the patient as a function of the ventricular contractile status. Examples of responses may include administration of drug or neuro therapies, modification of a pacing rate, or the like. Force interval potentiation may also be used to optimize or improve a parameter for a response provided by the implantable medical device.

Claims

1. A method of improving a ventricular contractile status of a patient with an implantable medical device, the method comprising the steps of:

observing a cardiac perturbation of a patient during a first cardiac cycle, wherein said cardiac perturbation comprises one of an extra-systole and a premature contraction of a cardiac chamber;

measuring heart beat potentiation of the cardiac perturbation for at least one subsequent cardiac cycle;

quantifying the measured heart beat potentiation to determine the ventricular contractile status of the patient; and

providing a response from the implantable medical device to the patient as a function of the quantified ventricular contractile status.

2. The method of claim 1 wherein the observing step further comprises inducing the cardiac perturbation in the patient via a cardiac pacing stimulus delivered from an implantable medical device.

3. The method of claim 2 wherein the cardiac perturbation comprises a premature ventricular contraction.

4. The method of claim 2 wherein the cardiac perturbation comprises an extra-systolic atrial beat.

5. The method of claim 2 wherein the cardiac perturbation comprises a change in heart rate induced via delivery of the cardiac pacing stimulus.

6. The method of claim 2 wherein the cardiac perturbation further comprises a change in hemodynamic pressure.

7. The method of claim 1 wherein the quantifying step comprises calculating a recirculation fraction as a function of the heart beat potentiation for the at least one subsequent cardiac cycle.

8. The method of claim 1 wherein the quantifying step comprises calculating a potentiation ratio as a function of the heart beat potentiation for the at east one subsequent cardiac cycle.

9. The method of claim 1 wherein the quantifying step comprises calculating a potentiation ratio and a recirculation fraction as a function of the heart beat potentiation for the at least one subsequent cardiac cycle.

10. The method of claim 1 wherein the response comprises providing a medication to the patient.

11. The method of claim 1 wherein the response comprises providing an electrical signal to the heart.

12. The method of claim 1 wherein the response comprises neurological stimulation to the patient.

13. The method of claim 1 wherein the response comprises adjusting a timing parameter.

14. The method of claim 1 wherein the response comprises storing data about the hemodynamic status in the implantable medical device.

15. The method of claim 1 further comprising the steps of gathering feedback data about the heart as the response is provided, and adjusting the response as a function of the feedback data.

16. The method of claim 15 wherein the response comprises providing a medication to the patient.

17. The method of claim 15 wherein the response comprises adjusting a timing parameter.

18. A method of improving a ventricular contractile status of a patient with an implantable medical device, the method comprising the steps of:

producing an extra-systolic beat from an implantable medical device during a first cardiac cycle;

measuring potentiation in a ventricular force interval resulting from the extra-systolic beat during at east one subsequent cardiac cycle;

quantifying the potentiation in the ventricular force interval to determine the ventricular contractile status of the patient; and

adjusting a parameter of a stimulus provided by the implantable medical device to the patient as a function of the determined ventricular contractile status.

19. A medical device configured to be implanted in a patient, the device comprising:

a data collection module configured to identify contractile potentiation in the patient following a cardiac perturbation for a first cardiac cycle;

a data processing module in communication with the data collection module, wherein the data processing module is configured to correlate the contractile potentiation to a hemodynamic status of the patient for at least one subsequent cardiac cycle; and

a response module in communication with the data processing module, wherein the response module is configured to provide a response based upon the correlated hemodynamic status.

20. The device of claim 19 further comprising a digital memory in communication with the data processing module, and wherein the response further comprises storing historical data about the hemodynamic status in the digital memory.

21. The device of claim 19 wherein the response module comprises an interface to at least one pacing electrode.

22. The device of claim 21 wherein the data processing module is further configured to induce the perturbation in the patient using the at least one pacing electrode.

23. The device of claim 19 wherein the data processing module is further configured to adjust the response as a function of the response.

24. The device of claim 23 wherein the response comprises administering a drug therapy to a patient.

25. The device of claim 23 wherein the response comprises adjusting a pacing parameter.

26. A medical device implanted in a patient, the method comprising the steps of:

means for observing a cardiac perturbation of a patient for a first cardiac cycle;

means for measuring potentiation in ventricular force resulting from the cardiac perturbation during at least one subsequent cardiac cycle;

means for quantifying the potentiation to determine a hemodynamic status of the patient; and

means for providing a response to the patient as a function of the hemodynamic status of the patient.

27. The medical device of claim 26 further comprising means for inducing the cardiac perturbation in the patient from the implantable medical device.

28. A method of calibrating a parameter using an implantable medical device, the method comprising the steps of:

providing a cardiac perturbation to a patient from an implantable medical device using an initial value of the parameter during a first cardiac cycle;

observing contractile potentiation in the patient as a result of the cardiac perturbation for at east one subsequent cardiac cycle;

adjusting a value of the parameter in response to the observed contractile potentiation; and

repeating the adjusting and observing steps until a maximum amount of contractile potentiation is observed in the patient.

29. The method of claim 28 further comprising the step of setting an optimal value for the parameter, wherein the optimal value corresponds to the value used to generate the maximum amount of contractile potentiation.

30. The method of claim 28 wherein the parameter is a pacing interval.

31. The method of claim 30 wherein the pacing interval is an AV pacing interval.

32. The method of claim 30 wherein the pacing interval is a VV pacing interval.

33. The method of claim 29 wherein the parameter is a drug therapy.

34. The method of claim 29 wherein the parameter is a neurotherapy.

35. The method of claim 28 wherein the cardiac perturbation comprises a premature ventricular contraction.

36. The method of claim 28 wherein the cardiac perturbation comprises a change in hemodynamic pressure.

37. The method of claim 28 wherein the cardiac perturbation comprises an extra-systolic beat.