Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor
First Claim
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1. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an effective amount of AcaNAPc2 (SEQ ID NO:
- 3).
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Abstract
The present invention provides methods of treating hemorrhagic fevers where selective inhibitors of fVIIa/TF are used as a treatment for hemorrhagic fevers and have therapeutic effects which include ameliorating and/or preventing coagulopathy and inflammatory responses. These inhibitors include certain proteins which are part of a family termed Nematode-Extracted Anticoagulant Proteins (“NAPs”). Other inhibitors include Tissue Factor Pathway Inhibitor (“TFPI”) and TFPI analogs.
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Citations
36 Claims
- 1. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an effective amount of AcaNAPc2 (SEQ ID NO:
- 2. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an effective amount of AcaNAPc2/proline (SEQ ID NO:
- 3. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an effective amount of tissue factor pathway inhibitor (TFPI).
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28. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an amount of AcaNAPc2 (SEQ ID No.:
- 3) effective to ameliorate symptoms of said fever.
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29. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an amount of AcaNAPc2/proline (SEQ ID No.:
- 4) effective to ameliorate symptoms of said fever.
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30. A method of treating a mammal suffering from a viral hemorrhagic fever, the method comprising administering an amount of tissue factor pathway inhibitor (TFPI) effective to ameliorate symptoms of said fever.
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