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First Claim
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1. A method for identifying a polypeptide in a sample from a mammal of a randomly breeding population, comprising:
- (a) characterizing said polypeptide by isoelectric point;
(b) characterizing said polypeptide by molecular weight; and
(c) identifying tissues of said subject where said polypeptide is found, wherein at least 5 tissues are examined, to yield distinguishing parameters of said polypeptide comprising isoelectric point, molecular weight and tissue distribution;
(d) comparing said distinguishing parameters of said polypeptide with distinguishing parameters of previously tested polypeptides of a set; and
(e) determining whether a previously tested polypeptide of said set has said distinguishing parameters of said polypeptide,wherein said polypeptide is identified as being said previously tested polypeptide when said distinguishing parameters of said polypeptide match the parameters of said previously tested polypeptide, or adding said polypeptide and said distinguishing parameters to said set when said distinguishing parameters of said polypeptide are unique to said set.
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Abstract
Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database.
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Citations
22 Claims
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1. A method for identifying a polypeptide in a sample from a mammal of a randomly breeding population, comprising:
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(a) characterizing said polypeptide by isoelectric point; (b) characterizing said polypeptide by molecular weight; and (c) identifying tissues of said subject where said polypeptide is found, wherein at least 5 tissues are examined, to yield distinguishing parameters of said polypeptide comprising isoelectric point, molecular weight and tissue distribution; (d) comparing said distinguishing parameters of said polypeptide with distinguishing parameters of previously tested polypeptides of a set; and (e) determining whether a previously tested polypeptide of said set has said distinguishing parameters of said polypeptide, wherein said polypeptide is identified as being said previously tested polypeptide when said distinguishing parameters of said polypeptide match the parameters of said previously tested polypeptide, or adding said polypeptide and said distinguishing parameters to said set when said distinguishing parameters of said polypeptide are unique to said set. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A data processing system for determining identity of an element (N+1) to N elements of a database contained in a storage medium comprising:
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(a) computer processing means for processing data; (b) data storage means for storing data in said database contained in said storage medium; and (c) means for processing data regarding comparing a parameter of said (N+1) element with said parameter of said N elements of said database, wherein said element is a protein or polypeptide;
wherein step (c) is repeated at least M times, wherein each of M parameters is examined at each iteration, wherein M is 3 or more; andwherein when said (N+1) element does not have M identical parameters of one of said N elements, said data storage means (b) adds data of said (N+1) element and of said M parameters thereof to said database to produce a new database comprising (N+1) elements. - View Dependent Claims (20, 21, 22)
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Specification