Tissue electroperforation for enhanced drug delivery and diagnostic sampling
First Claim
Patent Images
1. A method for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of:
- creating an air gap between an array of treatment electrodes and said membrane;
ablating said membrane with an electric current from the array of treatment electrodes wherein said electric current forms an electric arc between said treatment electrodes and said membrane; and
utilizing a driving force to move said molecule through said ablated membrane, wherein said membrane is skin.
8 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said membrane with an electric current from an array of treatment electrodes; and utilizing a driving force to move said molecule through said perforated membrane.
-
Citations
30 Claims
-
1. A method for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of:
-
creating an air gap between an array of treatment electrodes and said membrane;
ablating said membrane with an electric current from the array of treatment electrodes wherein said electric current forms an electric arc between said treatment electrodes and said membrane; and
utilizing a driving force to move said molecule through said ablated membrane, wherein said membrane is skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A method for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of:
-
creating an air gap between an array of treatment electrodes and said membrane;
selectively energizing at least one electrode of the array of treatment electrodes with an electric current to ablate the membrane wherein there is an air gap between said treatment electrodes and said membrane and said electric current forms an electric arc between said treatment electrodes and said membrane;
sensing the depth of ablation penetration of the membrane;
comparing the sensed depth of ablation penetration with a predetermined threshold; and
utilizing a driving force to move said molecule through said ablated membrane. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
-
Specification