Method for utilizing human tissue

• US 7,134,437 B2
• Filed: 03/22/2002
• Issued: 11/14/2006
• Est. Priority Date: 06/28/1990
• Status: Expired due to Fees

• Current Assignee: Bonutti Skeletal Innovations LLC (Acacia Research Corporation)
• Original Assignee: Bonutti IP LLC
• Inventors: Bonutti, Peter M.
• Primary Examiner(s): Hayes, Michael J.
• Assistant Examiner(s): NGUYEN, VI X
• Application Number:
  US10/104,250
• Publication Number:
  US 20020099401A1
• Time in Patent Office: 1,698 Days
• Field of Search: 128/898, 823/23.63, 823/23.72
• US Class Current: 128/898
• CPC Class Codes: A61B 10/025 for taking bone, bone marrow or cartilage samples
• CPC Class Codes: A61B 17/1615 Drill bits, i.e. rotating tools extending from a handpiece to contact the worked material
• CPC Class Codes: A61B 17/1631 Special drive shafts, e.g. flexible shafts A61B17/1642, A61B17/164 take precedence
• CPC Class Codes: A61B 17/1635 for grafts, harvesting or transplants
• CPC Class Codes: A61B 17/32002 with continuously rotating, oscillating or reciprocating cutting instruments
• CPC Class Codes: A61B 2017/00831 Material properties
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61B 2217/007 with irrigation system
• CPC Class Codes: A61M 1/79 Filters for solid matter specially adapted for dental use A61C17/065

Abstract

Percutaneous tissue removal apparatus comprises a flexible drill shaft, a cutting tip mounted on the shaft for placement adjacent a tissue mass for cutting the tissue, means for transmitting motion to the shaft to move the cutting tip against the tissue to cut tissue fragments from the tissue, and means for removing the tissue fragments along the shaft by suction to a location outside the tissue mass while cutting. The apparatus may include means for collecting one or more selected components of the harvested tissue fragments for implantation of the fragments preferably into the body of the patient from whom they were removed. Where the tissue to be cut is bone, a cutting tip is preferably made of a polymeric material which is softer than the cortical portion of the bone, although the cutting tip may be made of a ceramic or a composite material. A second flexible shaft may be provided either within or about the flexible drill shaft. The harvested tissue fragments may be implanted in the donor patient'"'"'s body.

Claims

1. A method of using human tissue, said method comprising the steps of removing blood from a human patient, centrifuging the blood removed from the human patient to at least partially remove a component from the blood, placing tissue graft material and the component from the blood into a mold, pressing at least one of the tissue graft material and the component from the blood in the mold to form an implant, removing the implant from the mold, and implanting the implant in the patient from which the blood was removed.

2. A method as set forth in claim 1 wherein the implant includes collagen.

3. A method as set forth in claim 1 wherein tho implant includes antibiotics.

4. A method as set forth in claim 1 wherein, the implant includes hydroxyapatite.

5. A method as set forth in claim 1 wherein said step of implanting the implant in the patient includes implanting the implant in a bone in the patient'"'"'s body.

6. A method as set forth in claim 1 wherein said step of implanting the implant in the patient includes positioning the implant in a biodegradable retainer and positioning the biodegradable retainer in the patient'"'"'s body.

7. A method as set forth in claim 1 wherein said step of implanting the implant in the patient includes moving the implant through a cannula to a desired location in the human patient.

8. A method as set forth in claim 1 wherein said step of removing blood from a human patient includes conducting the blood from the patient under the influence of suction.

9. A method of using human tissue, said method comprising the steps of removing blood from the human patient, centrifuging blood removed from the human patient to at least partially remove one or more components from the blood, and implanting in the patient a blood component remaining after centrifliging the blood, wherein said step of implanting a blood component in the patient includes moving a biodegradable bag into the patient.

10. A method of using human tissue, said method comprising the steps of removing tissue from a first location in a human patient, and implanting at least a portion of the tissue at a second location in the human patient, said step of implanting at least a portion of the tissue at a second location in the human patient includes moving a biodegradable bag to the second location in the human patient.

11. A method as set forth in claim 10 wherein said step of implanting the tissue at the second location in the human patient includes moving at least a portion of the tissue removed from the first location in the human patient to the second location in the human patient.

12. A method as set forth in claim 10 wherein said step of removing tissue from a first location in a human patient includes removing blood from the human patient, said method further includes centrifuging blood removal from the human patient to at least partially remove one or more components from the blood, said step of implanting the tissue at the second location in the human patient includes moving at least a portion of the blood to the second location in the human patient after centrifuging the blood.

13. A method as set forth in claim 10 wherein said step of moving the biodegradable bag to the second location in the human patient includes moving the biodegradable bag through a cannula.

14. A method as set forth in claim 10 wherein said step of implanting at least a portion of the tissue at the second location in the human patient includes moving the human tissue through a cannula with the human tissue in the biodegradable bag.

15. A method of utilizing human tissue, said method comprising the steps of:

percutaneously harvesting tissue from bone of a human donor;

conveying the harvested tissue to a location outside the body of the donor through a sterile passage;

collecting the harvested tissue in a container operatively associated with the sterile passage;

placing tissue graft material and the harvested tissue in a form;

pressing at least one of the tissue graft material and harvested tissue in the font to create a tissue graft plug;

removing the tissue graft plug from the form; and

implanting the tissue graft plug into a human recipient.

16. A method as set forth in claim 15 wherein the tissue graft plug is implanted into a bone of the recipient.

17. A method as set forth in claim 16 wherein the donor and recipient are the same individual.

18. A method as set forth in claim 17 further comprising the step of separating out at least one component from the harvested tissue and wherein the tissue graft material and the at least one component are placed in the form and are pressed to create the tissue graft plug.

19. A method as set forth in claim 18 wherein a fitter is used for the separation step.

20. A method as set forth in claim 18 wherein centrifugation is used for the separation step.

21. A method as set forth in claim 17 wherein the tissue graft plug includes viable tissue.

22. A method as set forth in claim 17 wherein the tissue graft plug includes fibrin.

23. A method as set forth in claim 17 further comprising the step of adding a bone growth promoting substance to the tissue graft plug.

24. A method as set forth in claim 23 wherein the bone growth promoting substance is hydroxyapatite or tricalcium phosphate.

25. A method as set forth in claim 17 further comprising the step of adding collagen to the tissue graft plug.

26. A method as set forth in claim 17 further comprising the step of adding an antibiotic to the tissue graft plug.

27. A method as set forth in claim 16 further comprising the step of passing the harvested tissue through a filter.

28. A method as set forth in claim 27 wherein the tissue graft plug includes viable tissue.

29. A method as set forth in claim 28 wherein the donor and recipient are the same individual.

30. A method of utilizing human tissue, said method comprising the steps of:

harvesting tissue from a human patient;

removing blood from the harvested tissue;

separating a blood component from the removed blood;

combining the blood component with the harvested tissue to form an implant; and

implanting the implant into the human patient,

wherein prior to implantation the implant is compressed in a mold.

31. A method as set forth in claim 30 wherein the tissue is bone tissue.

32. A method as set forth in claim 31 wherein a filter is used for the separation step.

33. A method as set forth in claim 31 wherein centrifugation is used for the separation step.

34. A method as set forth in claim 33 wherein the implant includes viable tissue.

35. A method as set forth in claim 31 wherein the blood component includes fibrin.

36. A method as set forth in claim 31 further comprising the step of adding a bone growth promoting substance to the implant prior to implantation.

37. A method as set forth in claim 36 wherein the bone growth promoting substance is hydroxyapatite or tricalcium phosphate.

38. A method as set forth in claim 31 further comprising the step of adding collagen to the implant prior to implantation.

39. A method as set forth in claim 31 further comprising the step of adding an antibiotic to the implant prior to implantation.