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Immunoliposomes that optimize internalization into target cells

  • US 7,135,177 B2
  • Filed: 02/28/2001
  • Issued: 11/14/2006
  • Est. Priority Date: 11/09/1994
  • Status: Expired due to Fees
First Claim
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1. An immunoliposome that is internalized into a cell bearing a HER2 growth factor receptor on its cell surface, said immunoliposome comprising:

  • a hydrophilic polymer derivatized lipid;

    a recombinantly produced antibody fragment specifically binding to the HER2 receptor on the cell surface said fragment attached to the hydrophilic polymer of the derivatized lipid; and

    ,an amphipathic vesicle-forming lipid, said vesicle-forming lipid forming a liposome; and

    ,wherein when said immunoliposome is contacted with said cell bearing a HER2 growth factor receptor on its cell surface, said immunoliposome is internalized into the cell.

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