Treatment of humans with colloidal silver composition

• US 7,135,195 B2
• Filed: 08/15/2003
• Issued: 11/14/2006
• Est. Priority Date: 06/01/1999
• Status: Expired due to Term

• Current Assignee: American Silver LLC
• Original Assignee: American Silver LLC
• Inventors: Holladay, Robert J., Moeller, William D., Christensen, Herbert
• Primary Examiner(s): Pak, John
• Application Number:
  US10/641,938
• Publication Number:
  US 20050061678A1
• Time in Patent Office: 1,187 Days
• Field of Search: 424/618, 424/405, 424/489, 424/490, 424/616, 514/849, 514/858, 514/894, 514/895, 514/924, 514/931, 514/932, 514/934, 514/951
• US Class Current: 424/618
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/0046 Ear
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61L 2/16 using chemical substances
• CPC Class Codes: A61L 2/186 Peroxide solutions
• CPC Class Codes: A61L 2/238 Metals or alloys, e.g. oligodynamic metals
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/02 for disorders of the vagina
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 : Local antiseptics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: B01F 27/91 : with propellers
• CPC Class Codes: B01F 33/05 : Mixers using radiation, e.g. magnetic fields or microwaves to mix the material B01F23/2133, B01F23/238, B01F23/55, B01F33/3031, B01F33/3032 take precedence
• CPC Class Codes: B01F 33/051 : the energy being electrical energy working on the ingredients or compositions for mixing them
• CPC Class Codes: B01J 13/0043 : containing elemental metal for medical or diagnostical purposes A61K, G01N
• CPC Class Codes: B01J 19/087 : employing electric or magnetic energy
• CPC Class Codes: B01J 19/18 : Stationary reactors having moving elements inside B01J19/08, B01J19/26 take precedence
• CPC Class Codes: B01J 2219/082 : Sliding electrodes
• CPC Class Codes: B01J 2219/0835 : substantially flat
• CPC Class Codes: B01J 2219/0841 : Metal
• CPC Class Codes: B01J 2219/089 : Liquid-solid
• CPC Class Codes: C02F 1/4606 : for producing oligodynamic substances to disinfect the water
• CPC Class Codes: C02F 2303/04 : Disinfection

Abstract

We disclose a colorless composition comprising silver particles and water, wherein said particles comprise an interior of elemental silver and an exterior of ionic silver oxide, wherein the silver particles are present in the water at a level of about 5–40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described.

Claims

1. A composition of silver in water comprising a total concentration of silver of between about 5 and 40 parts per million, said silver in the form of colloidal silver particles having an interior of elemental silver and a surface of silver oxide, wherein a majority of the colloidal silver particles have a maximum diameter less than 0.015 micrometers, wherein a majority of the colloidal silver particles have a minimum diameter greater than 0.005 micrometers, and wherein the composition exibits antimicrobial properties.

2. The composition according to claim 1, wherein at least 75% of the colloidal particles have diameters between 0.005 micrometers and 0.015 micrometers.

3. The composition according to claim 2, wherein at least 90% of the colloidal particles have diameters between 0.005 micrometers and 0.015 micrometers.

4. The composition according to claim 3, wherein at least 95% of the colloidal particles have diameters between 0.005 micrometers and 0.015 micrometers.

5. The composition according to claim 1, wherein the colloidal particles have an average diameter of about 0.0106 micrometers.

6. The composition according to claim 1 further comprising hydrogen peroxide.

7. The composition according to claim 6, wherein the hydrogen peroxide concentration is between about 1% wght/v and about 3.0% wght/v.

8. The composition according to claim 1, wherein the composition exhibits antimicrobial properties against microbes selected from the group consisting of Bacillus anthracis, Bacillus subtilis, Candida albicans, Mycobacteria bovis, Mycobacteria tuberculosis, Pseudomonas aeruginosa, Salmonella choleraesius, Staphylococcus aureus, Trichomonas vaginalis, and Yersinia pestis.

9. The composition according to claim 8, wherein Staphylococcus aureus is a methicillin-resistant strain.

10. The composition according to claim 1, wherein the composition exhibits antimicrobial properties against microbes associated with diseases selected from the group consisting of malaria, fungal infections of the skin, bacterial infections of the skin, vaginal infections, urinary tract infections, tonsillitis, pelvic inflammatory disease, pharyngitis, gonorrhea, conjunctivitis, otitis, respiratory tract infections, and nasal infections.

11. The composition according to claim 1, wherein the antimicrobial properties are antiviral properties.

12. The composition according to claim 11, wherein the antiviral properties are exhibited against a virus selected from the group consisting of human immunodeficiency virus and hepatitis B virus.

13. The composition according to claim 11, wherein the antiviral properties include inhibition of viral DNA polymerase.

14. The composition according to claim 11, wherein the antiviral properties include inhibition of viral reverse transcriptase.