Compositions that specifically bind to colorectal cancer cells and methods of using the same
First Claim
1. An isolated nucleic acid molecule consisting of a fragment of the nucleic acid sequence of SEQ ID NO:
- 1 consisting of 30–
200 nucleotides including nucleotides 110–
113 of SEQ ID NO;
1.
1 Assignment
0 Petitions
Accused Products
Abstract
A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.
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Citations
19 Claims
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1. An isolated nucleic acid molecule consisting of a fragment of the nucleic acid sequence of SEQ ID NO:
- 1 consisting of 30–
200 nucleotides including nucleotides 110–
113 of SEQ ID NO;
1. - View Dependent Claims (2)
- 1 consisting of 30–
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3. An isolated nucleic acid molecule consisting of the nucleic acid sequence of SEQ ID NO:
- 1 or SEQ ID NO;
2. - View Dependent Claims (4, 5, 6)
- 1 or SEQ ID NO;
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7. An isolated oligonucleotide molecule that is the full complement of a fragment of SEQ ID NO:
- 1, said fragment consisting of 30–
200 nucleotides of SEQ ID NO;
1 including nucleotides 110–
113 of SEQ ID NO;
1. - View Dependent Claims (8)
- 1, said fragment consisting of 30–
-
9. An isolated oligonucleotide molecule that is the full complement of a fragment of SEQ ID NO:
- 1, said fragment comprising 18 nucleotides of SEQ ID NO;
1 including nucleotides 110–
113 of SEQ ID NO;
1. - View Dependent Claims (10)
- 1, said fragment comprising 18 nucleotides of SEQ ID NO;
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11. An isolated oligonucleotide molecule comprising a nucleotide sequence that is the full complement of a fragment of SEQ ID NO:
- 1, said fragment comprising 18 nucleotides of SEQ ID NO;
1 including nucleotides 110–
113 of SEQ ID NO;
1;
wherein said oligonucleotide molecule hybridizes to a nucleic acid molecule consisting of SEQ ID NO;
1 without hybridizing to a nucleic acid molecule consisting of SEQ ID NO;
83. - View Dependent Claims (12, 13, 14, 15, 16)
- 1, said fragment comprising 18 nucleotides of SEQ ID NO;
- 17. An isolated nucleic acid molecule that consists of SEQ ID NO:
Specification