Methods of fabricating polymeric structures incorporating microscale fluidic elements
First Claim
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1. A method of fabricating a microfluidic device, comprising:
- providing a first substrate having at least a first surface and a second substrate having at least a first surface, wherein at least one of the first surface of the first substrate or the first surface of the second substrate comprises a textured surface having a plurality of texturing structures fabricated thereon, the textured surface not comprising an applied adhesive, and wherein at least one of the first surface of the first substrate or the first surface of the second substrate comprises a groove fabricated therein, the groove not forming a portion of the texturing structures; and
mating and bonding the first surface of the first substrate to the first surface of the second substrate, while at the same time deforming the textured surface, the groove defining a channel when the first and second substrates are mated and bonded.
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Abstract
The present invention generally provides improved methods of fabricating polymeric microfluidic devices that incorporate microscale fluidic structures, whereby the fabrication process does not substantially distort or deform such structures. The methods of the invention generally provide enhanced bonding processes for mating and bonding substrate layers to define the microscale channel networks therebetween.
148 Citations
15 Claims
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1. A method of fabricating a microfluidic device, comprising:
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providing a first substrate having at least a first surface and a second substrate having at least a first surface, wherein at least one of the first surface of the first substrate or the first surface of the second substrate comprises a textured surface having a plurality of texturing structures fabricated thereon, the textured surface not comprising an applied adhesive, and wherein at least one of the first surface of the first substrate or the first surface of the second substrate comprises a groove fabricated therein, the groove not forming a portion of the texturing structures; and mating and bonding the first surface of the first substrate to the first surface of the second substrate, while at the same time deforming the textured surface, the groove defining a channel when the first and second substrates are mated and bonded. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification