System and method for monitoring cardiac function via cardiac sounds using an implantable cardiac stimulation device

• US 7,139,609 B1
• Filed: 01/17/2003
• Issued: 11/21/2006
• Est. Priority Date: 01/17/2003
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Min, Xiaoyi, Park, Euljoon, Levine, Paul A.
• Primary Examiner(s): Pezzuto, Robert E.
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US10/346,809
• Time in Patent Office: 1,404 Days
• Field of Search: 600/508, 600/509, 600/513, 600/528, 600/586, 607/9, 607/17, 607/24
• US Class Current: 607/17
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

Techniques are provided for performing internal measurement of heart sounds to estimate patient cardiac function in terms of stroke volume, cardiac output, or a maximum rate of change of aortic pressure with time (max dP/dt). Control parameters of the medical device are then automatically adjusted so as to optimize overall cardiac function or to provide for ventricular resynchronization therapy. In one example, heart sound signals are derived from acceleration signals received from an accelerometer. The heart sound signals are analyzed to identify S1 and S2 heart sounds as well as ejection period and isovolumic interval (ISOV). Proxies for max dP/dt, stroke volume and cardiac output are then derived from the S1 and S2 heart sounds, the ejection period and the ISOV. Alternative techniques, not requiring detection of ISOV, are employed for use if the patient has heart value regurgitation.

Claims

1. In an implantable cardiac stimulation device for implant within a patient, a method comprising:

detecting heart sound signals;

determining whether systolic regurgitant murmurs are occurring during an ejection period; and

processing the heart sound signals to derive one or more parameters representative of cardiac function of the patient, wherein the one or more parameters comprise stroke volume, cardiac output, and maximum rate of change of aortic pressure over time.

2. The method of claim 1 wherein determining one or more parameters representative of cardiac function of the patient comprises:

determining two or more parameters representative of cardiac function of the patient.

3. The method of claim 1 wherein detecting heart sound signals comprises:

detecting acceleration signals representative of the acceleration of tissues within the patient; and

converting the acceleration signals into heart sound signals.

4. The method of claim 3 wherein determining one or more parameters representative of cardiac function comprises:

identifying S1 and S2 heart sounds within the heart sound signals.

5. The method of claim 3 further comprising detecting electrocardiographic signals representative of electrical characteristics of the heart.

6. The method of claim 5 wherein identifying S1 and S2 heart sounds comprises:

detecting ventricular depolarization signals and ventricular repolarization signals within the electrocardiographic signals;

defining S1 and S2 search windows within the heart sound signals subsequent to the ventricular depolarization and repolarization signals, respectively; and

detecting the S1 and S2 heart sounds within, respectively, the S1 and S2 search windows.

7. The method of claim 6 wherein detecting the S1 and S2 heart sounds comprises

rectifying the heart sound signals;

determining a maximum of the rectified heart sound signal within each of the S1 and S2 windows;

setting S1 and S2 detection thresholds based on the maximum of the rectified heart sound signals; and

identifying the S1 and S2 heart sounds based on a comparison of the rectified heart sound signal within the detection thresholds within the respective S1 and S2 search windows.

8. The method of claim 6 further comprising detecting the duration of an ejection period based on the S1 and S2 heart sounds.

9. The method of claim 8 wherein detecting the duration of the ejection period is performed to determine the time interval from the end of the S1 sound to the beginning of the S2 sound.

10. The method claim 9 further comprising detecting heart rate based on the electrocardiographic signals.

11. The method of claim 10 further comprising detecting a maximum of the S1 heart sound (max_S1).

12. The method of claim 11 wherein determining whether systolic regurgitant murmurs are occurring during the ejection period comprises determining a peak to peak maximum of the heart sound signal during a murmur detection interval and comparing the maximum heart sound in the murmur detection interval to a pre-determined murmur detection threshold.

13. The method of claim 11 wherein determining one or more parameters representative of cardiac function comprises:

determining, if there are no systolic regurgitant murmurs during the ejection period, an isovolumic interval (ISOV) from the S1 heart sound.

14. The method of claim 13 wherein determining one or more parameters representative of cardiac function comprises:

estimating, if there are no systolic regurgitant murmurs during the ejection period, max dP/dt based on;

P_max_—

dP/dt=max_—

S1/ISOV

wherein P_max_dP/dt is a predictor for max_dP/dt.

15. The method of claim 13 wherein determining one or more parameters representative of cardiac function comprises:

estimating, if there are no systolic regurgitant murmurs during the ejection period, max dP/dt based on;

P_max_—

dP/dt=80 mm Hg/ISOV

wherein P_max_dP/dt is a predictor for max dP/dt.

16. The method of claim 13 wherein determining one or more parameters representative of cardiac function comprises:

estimating, if there are no systolic regurgitant murmurs during the ejection period, stroke volume based on;

P_—

SV=11/18*EJT_—

prd*S1_max/ISOV

wherein P_SV is a predictor for stroke volume.

17. The method of claim 16 wherein determining one or more parameters representative of cardiac function comprises:

estimating cardiac output based on;

P_—

CO=P_—

SV*heart rate.

18. The method of claim 13 wherein determining one or more parameters representative of cardiac function comprises:

estimating, if there are systolic regurgitant murmurs during the ejection period, max dP/dt based on;

P_max_—

dP/dt=max_—

S1

wherein P_max_dP/dt is a predictor for max_dP/dt.

19. The method of claim 13 wherein determining one or more parameters representative of cardiac function comprises:

estimating, if there are systolic regurgitant murmurs during the ejection period, stroke volume based on;

P_—

SV=11/18*EJT_—

prd*S1_max

wherein P_SV is a predictor for stroke volume.

20. The method of claim 19 wherein determining one or more parameters representative of cardiac function comprises:

estimating cardiac output based on;

P_—

CO=P_—

SV*heart rate.

21. The method of claim 3 wherein detecting signals representative of the acceleration of tissue within the patient comprises detecting internal acceleration signals.

22. The method of claim 21 wherein detecting acceleration signals comprises:

substantially filtering out all signals not representative of movement of the heart.

23. The method of claim 1 further comprising monitoring progression of heart failure in the patient by monitoring changes in parameters representative of cardiac function.

24. The method of claim 1 wherein the operation of the implantable stimulation device is controlled by control parameters and further comprising adjusting the control parameters based the parameters representative of cardiac function.

25. The method of claim 24 wherein adjusting the control parameters comprises:

adjusting the control parameters so as to resynchronize the ventricles.

26. The method of claim 24 wherein adjusting the control parameters is performed to adjust one or more of monoventricular pacing control parameters, biventricular pacing control parameters, four-chamber pacing control parameters or individual chamber multi-site pacing control parameters.

27. In an implantable cardiac stimulation device for implant within a patient, a system comprising:

means for detecting acceleration signals representative of the acceleration of tissues within the patient; and

means for converting the acceleration signals into heart sound signals

means for detecting systolic regurgitant murmurs during an ejection period; and

means for processing the heart sound signals to derive one or more parameters representative of cardiac function of the patient, wherein the one or more parameters comprise stroke volume, cardiac output, and maximum rate of change of aortic pressure over time.

28. The system of claim 27, and further comprising means for adjusting operation based on the one or more parameters.