Transfer device and cap assembly for use with a container and the transfer device

• US 7,140,401 B2
• Filed: 12/17/2002
• Issued: 11/28/2006
• Est. Priority Date: 12/17/2001
• Status: Expired due to Fees

• Current Assignee: Bristol-Myers Squibb Company
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: McLellan, Steven, Wilcox, Alun
• Primary Examiner(s): Douglas, Steven O.
• Application Number:
  US10/498,831
• Publication Number:
  US 20050016626A1
• Time in Patent Office: 1,442 Days
• Field of Search: 141/2, 141 21- 27, 141/329, 141/330, 141/59, 604411-416
• US Class Current: 141/2
• CPC Class Codes: A61J 1/1425 Snap-fit type
• CPC Class Codes: A61J 1/145 using air filters
• CPC Class Codes: A61J 1/1481 with connection retaining means, e.g. thread or snap-fit
• CPC Class Codes: A61J 1/1487 with friction fit, e.g. connecting tubes directly to a protruding port
• CPC Class Codes: A61J 1/18 Arrangements for indicating condition of container contents, e.g. sterile condition
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2051 having tap means, e.g. tap means activated by sliding
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2082 for gas filtration
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

The present invention is directed to a transfer device for fluid communication between a first site and a second site comprising a housing, a fluid channel and typically a sleeve assembly. The housing has a first end being connectable to the first site, a second end being connectable to the second site and a longitudinal portion extending between the first and second ends and defining a longitudinal axis. The housing includes two oppositely arranged wings comprising engaging means for engagement with the first site. The fluid channel is provided in the housing for fluid communication between the first end and the second end of the housing. The optionally provided sleeve assembly is mounted to the housing and axially movable relative to and biased against the housing.

Claims

1. A transfer device (2) for fluid communication between a first site and a second site, the transfer device (2) comprising:

a) a housing (4) having a first end being connectable to the first site, a second end being connectable to the second site and a longitudinal portion between the first and second ends defining a longitudinal axis (46), the housing (4) including two oppositely arranged wings (6, 8) comprising engaging means (10, 12) for engagement with the first site;

b) a fluid channel (44) provided in the housing (4) for fluid communication between the first end and the second end of the housing (4); and

c) a sleeve assembly (42) mounted to the housing (4), the sleeve assembly (42) being axially movable relative to and biased against the housing (4);

wherein the fluid channel (44) comprises at least one needle (48) extending from the housing (4) along the longitudinal axis (46), the needle (48) being completely accommodated in the sleeve assembly (42), when the transfer device (2) is non-actuated, and the needle (48) protruding from the sleeve assembly (42), when the transfer device (2) is axially compressed against the biasing force so as to move the sleeve assembly (42) relative to the housing (4).

2. The transfer device (2) of claim 1, wherein the sleeve assembly (42) comprises an inner sleeve (70) and an outer sleeve (72) defining a space (74) between them, the biasing force being provided by a compression spring (68) that is partially accommodated in the space (74) between the inner and outer sleeves (70, 72).

3. The transfer device (2) of claim 1, wherein the sleeve assembly (42) comprises a membrane (80) blocking access to the interior of the sleeve assembly (42) in which the at least one needle (48) is provided.

4. The transfer device (2) of claim 1, wherein the sleeve assembly (42) and the housing (4) comprise complementary guiding means (40, 82) for guiding the axial movement of the sleeve assembly (42) relative to the housing (4).

5. The transfer device (2) of claim 4, wherein the guiding means comprise at least one longitudinal slot (40) provided in the housing (4) and a retention tab (82) provided on the sleeve assembly (42), the retention tab (82) having a radially protruding portion extending into the slot (40).

6. The transfer device (2) of claim 1 further comprising a ventilation duct (50) provided in the housing (4) for allowing air to enter the first site.

7. The transfer device (2) of claim 6, wherein the fluid channel (44) and the ventilation duct (50) are arranged substantially in parallel with respect to one another.

8. The transfer device (2) of claim 7, wherein the fluid channel (44) and the ventilation duct (50) are arranged co-axially at least along a part of their length.

9. The transfer device (2) of claim 7, wherein each of the fluid channel (44) and the ventilation duct (50) comprise a hollow needle (48, 52).

10. The transfer device (2) of claim 6, wherein the ventilation duct (50) comprises a filter element (54) that is provided in an inlet opening (56) of the ventilation duct (50).

26. The transfer device (2) of claim 1, wherein the first site is a container (106), particularly a vial, from or into which fluid is to be transferred.

27. The transfer device (2) of claim 26, wherein the second site is a suction operated dispenser device with which fluid is sucked out of the first site, through the transfer device (2) an into the dispenser device and/or fluid is dispensed through the transfer device (2) into the first site.

28. The transfer device (2) of claim 27, wherein the suction operated dispenser device is a syringe.

29. The transfer device (2) of claim 1 further comprising luer connector (58) for connection to at least one of the sites.

30. The transfer device (2) of claim 29, wherein the luer connector (58) comprises a luer lid (60), a luer plunger (62) and a spring (64) being supported by the housing (4) and forcing the luer plunger (62) against the luer lid (60) so as to close the luer connector (58).

31. The transfer device (2) of claim 29, wherein the first site comprises a collar (112) or a cap assembly (102) mounted to the first site with which the wings (6, 8) are engagable.

32. A method for transferring fluid from a first site to a second site using the transfer device (2) of claim 1.

33. A cap assembly (102) for use with a container (106) and a transfer device, particularly a transfer device (2) of claim 1, said cap assembly (102) comprising:

a) a sleeve (104) having an inner surface provided with at least two axially spaced and radially inwardly extending protrusions (108, 110) that are adapted to receive a radially outwardly extending collar (112) of the container (106) therebetween so as to secure the cap assembly (102) at the container (106), and an outer surface provided with at least two axially spaced annular grooves (124, 126) and at least one recess (130); and

b) a cap (114) having a locking ring (116) and a removable cap portion (118), the locking ring (116) comprising at least one inwardly extending protrusion (122) being adapted to mate with said annular grooves (124, 126) provided on the outer surface of the sleeve (104).

34. The cap assembly (102) of claim 33, wherein the locking ring (116) and the removable cap portion (118) are interconnected by a line of weakness (128) that is adapted to break upon removal of the cap portion (118).

35. The cap assembly (102) of claim 34, wherein the locking ring (116) removably holds the cap portion (118) by a thread.

36. The cap assembly (102) of any claim 35, wherein the locking ring (116) is elastically deformable so that the inwardly extending protrusion (122) of the cap (114) snaps into at least one of the grooves (124, 126).

37. The cap assembly (102) of claim 36, wherein the recess (130) provided on the outer surface of the sleeve (104) is formed as an annular groove.

38. The cap assembly (102) of claim 37, wherein the recess (130) provided on the outer surface of the sleeve (104) is adapted to mate with an engaging means (10, 12) provided at the transfer device (2).

39. The cap assembly (102) of claim 38, wherein one of the two axially spaced annular grooves (126) is located adjacent a lower end of the sleeve (104) and the at least one recess (130) is located adjacent an upper end of the sleeve (104), while the other groove (124) is positioned relatively close to the at least one recess (130).

40. The cap assembly (102) of claim 39, wherein the sleeve (104) comprises a stop member (132) forming an abutment for the locking ring (116).

41. A method of mounting the cap assembly (102) of claim 40 to a container (106) comprising the steps of:

a) pushing the cap assembly (102) onto a collar (112) of a neck provided on the container (106) so that the collar (112) is accommodated between the two inwardly extending annular protrusions (108, 110) of the sleeve (104), while the cap (114) is in a mounting position in which the inwardly extending protrusion (122) of the locking ring (116) is engaged with an upper one of the two grooves (124) formed on sleeve (104); and

b) pushing the cap (114) from the mounting position into a locking position in which the cap assembly (102) is secured to the container (106), wherein in the locking position the inwardly extending protrusion (122) of the locking ring (116) is engaged with a lower one of the two grooves (124, 126) formed in the sleeve (104).

42. The method of claim 41 comprising the additional step of:

removing the cap portion (118) of the cap (114) from the locking ring (116) so as to expose the at least one recess (130) for engagement with engaging means (10, 12) of a transfer device (2).

11. A transfer device (2) for fluid communication between a first site and a second site, the transfer device (2) comprising:

a) a housing (4) having a first end being connectable to the first site, a second end being connectable to the second site and a longitudinal portion between the first and second ends defining a longitudinal axis (46), the housing (4) including two oppositely arranged wings (6, 8) comprising engaging means (10, 12) for engagement with the first site;

b) a fluid channel (44) provided in the housing (4) for fluid communication between the first end and the second end of the housing (4); and

c) a ventilation duct (50) provided in the housing (4) for allowing air to enter the site from which fluid is transferred;

wherein the fluid channel (44) and the ventilation duct (50) are arranged substantially in parallel with respect to one another.

12. The transfer device (2) of claim 11, wherein the fluid channel (44) and the ventilation duct (50) are arranged co-axially at least along a part of their length.

13. The transfer device (2) of claim 12, wherein each of the fluid channel (44) and the ventilation duct (50) comprise a hollow needle (48, 52).

14. The transfer device (2) of claim 13, wherein the ventilation duct (50) comprises a filter element (54) that is provided in an inlet opening (56) of the ventilation duct (50).

15. A transfer device (2) for fluid communication between a first site and a second site, the transfer device (2) comprising:

a) a housing (4) having a first end being connectable to the first site, a second end being connectable to the second site and a longitudinal portion between the first and second ends defining a longitudinal axis (46), the housing (4) including two oppositely arranged wings (6, 8) comprising engaging means (10, 12) for engagement with the first site; and

b) a fluid channel (44) provided in the housing (4) for fluid communication between the first end and the second end of the housing (4);

wherein each of the wings (6, 8) is pivotally hinged to the housing (4) and comprises a bridge section (20, 22) and a wing section (24, 26), the bridge section (20, 22) having two opposing ends and an intermediate part, and the wing section (24, 26) being connected to the bridge section (20, 22) and having a substantially curved shape so that end portions of the wings (6, 8) are further spaced from the housing (4) than a center portion located between the end portions.

16. The transfer device (2) of claim 15, wherein the hinge (16, 18) resiliently biases the wing (6, 8) in a potential engaging position.

17. The transfer device (2) of claim 16, wherein each of the bridge sections (20, 22) is hinged to the housing (4) at one of its ends and comprises on its other end a claw (10, 12) being engagable with the engaging means provided on the first and/or second site.

18. The transfer device (2) of claim 17, wherein each of the wing sections (24, 26) is connected to the intermediate part of the bridge sections (20, 22).

19. The transfer device (2) of claim 18, wherein each of the wing sections (24, 26) comprises a first curved portion being connected to the bridge sections (20, 22) and a second curved portion extending from the first curved portion and forming a finger grip region (32, 34) for actuating the wings (6, 8).

20. A transfer device (2) for fluid communication between a first site and a second site, the transfer device (2) comprising:

a) a housing (4) having a first end being connectable to the first site, a second end being connectable to the second site and a longitudinal portion between the first and second ends defining a longitudinal axis (46), the housing (4) including two oppositely arranged wings (6, 8) comprising engaging means (10, 12) for engagement with the first site;

b) a fluid channel (44) provided in the housing (4) for fluid communication between the first end and the second end of the housing (4); and

c) a sleeve assembly (42) mounted to the housing (4), the sleeve assembly (42) being axially movable relative to and biased against the housing (4);

wherein each of the wings (6, 8) is pivotally hinged to the housing (4), and the engaging means (10, 12) being engaged with the sleeve assembly (42) in a non-actuated position such that the sleeve assembly (42) is axially secured relative to the housing (4).

21. The transfer device (2) of claim 20, wherein each of the engaging means is formed as a claw (10, 12).

22. The transfer device (2) of claim 21, wherein the sleeve assembly (42) comprises a recess (88, 90) into which the engaging means (10, 12) of the wings (6, 8) engages.

23. The transfer device (2) of claim 22, wherein the sleeve assembly (42) comprises a ramp (92, 94) adjacent the recess, the ramp (92, 94) rising to the recess (88, 90) allowing a smooth travel of the engaging means (10, 12) into the recess (88, 90), when the transfer device (2) is brought from an actuated position into the non-actuated position.

24. A transfer device (2) for fluid communication between a first site and a second site, the transfer device (2) comprising:

a) a housing (4) having a first end being connectable to the first site, a second end being connectable to the second site and a longitudinal portion between the first and second ends defining a longitudinal axis (46), the housing (4) including two oppositely arranged wings (6, 8) comprising engaging means (10, 12) for engagement with the first site;

b) a fluid channel (44) provided in the housing (4) for fluid communication between the first end and the second end of the housing (4); and

c) a sleeve assembly (42) mounted to the housing (4), the sleeve assembly (42) comprising two oppositely arranged open ended slots (96, 98) extending along the longitudinal axis (46) and each having at least one protrusion (100);

wherein each of the slots (96, 98) is adapted to receive a mating portion of one of the sites from or into which fluid is to be communicated, wherein the protrusion (100) formed in each of the slots (96, 98) secures the mating portion into place.

25. The transfer device (2) of claim 24, wherein the protrusion (100) is a circumferentially extending protrusion which narrows the width of the slot (96, 98).