Micro perfusion device comprising a collecting container

• US 7,141,023 B2
• Filed: 08/21/2002
• Issued: 11/28/2006
• Est. Priority Date: 02/25/2000
• Status: Expired due to Fees

• Current Assignee: Disetronic Licensing Ag (Roche Holding AG)
• Original Assignee: Disetronic Licensing Ag (Roche Holding AG)
• Inventors: Haueter, Ulrich, Diermann, Ulrich
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): FOREMAN, JONATHAN M
• Application Number:
  US10/225,557
• Publication Number:
  US 20030047011A1
• Time in Patent Office: 1,560 Days
• Field of Search: 600/573, 600/576, 600/578, 600/580, 600/581, 600/309, 600/584, 604/27, 604/36, 604/37, 604/40, 604/43, 604/44, 604/164.01, 604/164.02, 604/164.06, 604/164.09, 604/164.11
• US Class Current: 600/573
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150366 Blood collection bags, e.g. connected to the patient by a catheter comprising means for removing a small sample of collected blood from the bag collection bags as such A61J1/05, A61M1/0209
• CPC Class Codes: A61B 5/150396 Specific tip design, e.g. for improved penetration characteristics
• CPC Class Codes: A61B 5/150511 Details of construction of shaft
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00

Abstract

A micro perfusion device including a casing, a perfusate supply, an inner cannula forming an inner lumen between a front cannula opening which is distal when the device is subcutaneously positioned and a rear cannula opening, the inner lumen being connected or connectable to the perfusate supply via the rear cannula opening, a perfusion cannula projecting from a lower side of the casing and surrounding the inner cannula, an outer lumen between the inner cannula and the perfusion cannula, a collecting container for the perfusate, and a perfusate outlet connecting the outer lumen to the collecting container, wherein the collecting container has a variable volume and a partial vacuum with respect to a pressure prevailing in the perfusate supply may be generated in the collecting container.

Claims

1. A micro perfusion device comprising a collecting container, for obtaining at least one constituent of a body fluid using a subcutaneously positioned perfusion cannula, said device comprising:

a) a casing;

b) a perfusate supply;

c) an inner cannula, forming an inner lumen between a front cannula opening which is distal when the device is subcutaneously positioned and a rear cannula opening, said inner lumen being connected or connectable to said perfusate supply via said rear cannula opening, said inner cannula being accommodated by said casing so as to be slidable in the longitudinal direction from a front sliding position to a rear sliding position and said rear cannula opening being formed in a surface area of said inner cannula;

d) a sealing ring surrounding said inner cannula in said casing under pressure and, in said rear sliding position of said inner cannula, pre-latching into said rear cannula opening;

e) a perfusion cannula, projecting from a lower side of said casing and surrounding said inner cannula, an outer lumen remaining between said inner cannula and said perfusion cannula;

f) a collecting container for said perfusate; and

g) an outlet for said perfusate, connecting said outer lumen to said collecting container;

wherein said collecting container is a variable-volume collecting container and a partial vacuum with respect to a pressure prevailing in said perfusate supply is generated in said collecting container.

2. A micro perfusion device comprising a collecting container, for obtaining at least one constituent of a body fluid using a subcutaneously positioned perfusion cannula, said device comprising:

a) a casing;

b) a perfusate supply;

c) an inner cannula, forming an inner lumen between a front cannula opening which is distal when the device is subcutaneously positioned and a rear cannula opening, said inner lumen being connected or connectable to said perfusate supply via said rear cannula opening;

d) the perfusion cannula, projecting from a lower side of said casing and surrounding said inner cannula, an outer lumen remaining between said inner cannula and said perfusion cannula;

e) a collecting container for said perfusate;

f) an outlet for said perfusate, connecting said outer lumen to said collecting container;

wherein said collecting container is a variable-volume collecting container and a partial vacuum with respect to a pressure prevailing in said perfusate supply is generated in said collecting container; and

g) a sensor of a measuring means, for measuring the concentration of the at least one constituent of said body fluid, the sensor being arranged in or on said casing, in said outlet.

3. The micro perfusion device as set forth in claim 2, wherein said sensor is arranged in an area of said outlet bordering said outer lumen.

4. The micro perfusion device as set forth in claim 2, wherein:

the measuring means comprises a working electrode and a counter electrode; and

said counter electrode is formed on a lower side of said casing which contacts a surface of the tissue once said inner cannula and said perfusion cannula have been positioned.

5. The micro perfusion device as set forth in claim 4, wherein said working electrode is formed in said outlet.

6. A micro perfusion device comprising a collecting container, for obtaining at least one constituent of a body fluid using a subcutaneously positioned perfusion cannula, said device comprising:

a) a casing;

b) a perfusate supply;

c) an inner cannula, forming an inner lumen between a front cannula opening which is distal when the device is subcutaneously positioned and a rear cannula opening, said inner lumen being connected or connectable to said perfusate supply via said rear cannula opening;

d) the perfusion cannula, projecting from a lower side of said casing and surrounding said inner cannula, an outer lumen remaining between said inner cannula and said perfusion cannula;

e) a collecting container for collecting and holding said perfusate;

f) and an outlet for said perfusate, connecting said outer lumen to said collecting container;

wherein

g) said collecting container is a variable-volume collecting container having an elastic container wall that includes a pre-tensioning means for holding the container in a compressed state.

h) and a partial vacuum with respect to a pressure prevailing in said perfusate supply is generated in said collecting container.

7. The device as set forth in claim 6, wherein the collecting container is substantially air-tight.

8. The micro perfusion device as set forth in claim 6, wherein the partial vacuum is generated by enlarging the volume of said collecting container, said partial vacuum suctioning said perfusate from said outer lumen into said collecting container.

9. The micro perfusion device as set forth in claim 6, wherein:

said inner cannula is accommodated by said casing so as to be slidable in the longitudinal direction from a front sliding position to a rear sliding position; and

said inner cannula is an injection needle, and in its front sliding position protrudes from said perfusion cannula and in its rear sliding position protrudes beyond said perfusion cannula.

10. The micro perfusion device as set forth in claim 6, wherein said perfusate supply is connected to a variable-volume perfusate storage container.