Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
First Claim
1. A method of enhancing fluid flow through a vascular site occupied by an organic matter comprising vascular occlusion, said method comprising:
- simultaneously flushing said vascular site with;
(i) an organic matter dissolution fluid; and
(ii) an organic matter dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said organic matter comprising vascular occlusion is contacted with non-attenuated organic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated organic matter dissolution fluid;
whereby fluid flow is enhanced through said vascular site.
6 Assignments
0 Petitions
Accused Products
Abstract
Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
68 Citations
27 Claims
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1. A method of enhancing fluid flow through a vascular site occupied by an organic matter comprising vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with; (i) an organic matter dissolution fluid; and (ii) an organic matter dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said organic matter comprising vascular occlusion is contacted with non-attenuated organic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated organic matter dissolution fluid; whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of enhancing fluid flow through a vascular site occupied by an inorganic matter comprising vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with; (i) an inorganic matter dissolution fluid; and (ii) an inorganic matter dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated inorganic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated inorganic matter dissolution fluid; whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A method of enhancing fluid flow through a vascular site occupied by vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with; (i) a dissolution fluid that dissolves both organic and inorganic matter; and (ii) a dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid; whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (16, 17, 18, 19, 20)
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21. A lesion dissolution fluid comprising:
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an acid; and a surfactant. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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Specification