Synergistic composition for the treatment of diabetes mellitus

• US 7,141,254 B2
• Filed: 05/14/2004
• Issued: 11/28/2006
• Est. Priority Date: 05/14/2003
• Status: Active Grant

• Current Assignee: Indus Biotech Pvt., Ltd.
• Original Assignee: Indus Biotech Pvt., Ltd.
• Inventors: Bhaskaran, Sunil, Mohan, Vishwaraman
• Primary Examiner(s): FLOOD, MICHELE C
• Application Number:
  US10/846,299
• Publication Number:
  US 20050008716A1
• Time in Patent Office: 928 Days
• Field of Search: 424/757, 424/754, 514/867, 514/77, 514/866
• US Class Current: 424/754
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/205 Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin
• CPC Class Codes: A61P 7/12 Antidiuretics, e.g. drugs for diabetes insipidus ADH A61P5/10

Abstract

The present invention relates to a synergistic composition for the treatment of diabetes in a subject in need thereof, said composition-comprising Trigonelline of concentration ranging between 20 to 30%, amino acids of concentration ranging between 20 to 60%, and soluble fiber of concentration ranging between 10 to 60%, optionally along with pharmaceutically acceptable additives, a process thereof and also, a method of treating diabetes.

Claims

1. A synergistic composition obtained from plant Fenugreek for the treatment of diabetes in a subject in need thereof, said Trigonelline of a concentration ranging between 20 to 30%, amino acids of a concentration ranging between 20 to 60%, and soluble fiber of a concentration ranging between 10 to 60%, optionally along with pharmaceutically acceptable additives.

2. A synergistic composition as claimed in claim 1, wherein the amino acids are selected from a group comprising L-arginine, Leucine, Isoleucine, and 4-Hydroxyisoleucine.

3. A synergistic composition as claimed in claim 1, wherein the soluble fiber is galactomannan.

4. A synergistic composition as claimed in claim 1, wherein the additives are extracted from fenugreek, which comprises a group containing galactomannan.

5. A synergistic composition as claimed in claim 1, wherein the diabetes is Type II diabetes.

6. A synergistic composition as claimed in claim 1, wherein the composition is free of adverse effects.