Methods and compositions for treatment of tumors using nucleic acid ligands to platelet-derived growth factor
First Claim
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1. A method for treating tumors comprising:
- a) pre-treating a host having a tumor by administering a therapeutically effective dose of a platelet-derived growth factor (PDGF) aptamer for a predetermined number of days; and
b) subsequently administering a therapeutically effective dose of a cytotoxic agent to said host.
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Abstract
A method is provided for treating solid tumors comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using the SELEX process for the Systematic Evolution of Ligands by Exponential enrichment. A method is also provided for reducing the interstitial fluid pressure (IFP) of a solid tumor comprising administering a PDGF aptamer. Finally, a method is provided for increasing the uptake of cytotoxic agents into a tumor comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent.
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Citations
10 Claims
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1. A method for treating tumors comprising:
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a) pre-treating a host having a tumor by administering a therapeutically effective dose of a platelet-derived growth factor (PDGF) aptamer for a predetermined number of days; and b) subsequently administering a therapeutically effective dose of a cytotoxic agent to said host. - View Dependent Claims (2, 3, 4, 5)
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6. A method for increasing the uptake of cytotoxic agents into a tumor comprising:
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a) pre-treating a host having a tumor by administering a therapeutically effective dose of a platelet-derived growth factor (PDGF) aptamer for a predetermined number of days; and b) subsequently administering a therapeutically effective dose of a cytotoxic agent to said host. - View Dependent Claims (7, 8, 9, 10)
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Specification