Device and process for simultaneous transfer of liquids

• US 7,141,433 B2
• Filed: 06/04/2002
• Issued: 11/28/2006
• Est. Priority Date: 12/31/2001
• Status: Expired due to Fees

• Current Assignee: Corning Incorporated
• Original Assignee: Corning Incorporated
• Inventors: Dannoux, Thierry L. A.
• Primary Examiner(s): Gordon, Brian R.
• Application Number:
  US10/163,216
• Publication Number:
  US 20030124734A1
• Time in Patent Office: 1,638 Days
• Field of Search: 422/100, 422/63, 436/180, 436/54
• US Class Current: 436/180
• CPC Class Codes: B01J 2219/00891 Feeding or evacuation
• CPC Class Codes: B01J 4/001 Feed or outlet devices as such, e.g. feeding tubes
• CPC Class Codes: B01L 2200/021 Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/5025 for parallel transport of multiple samples
• CPC Class Codes: B01L 3/563 Joints or fittings in general F16L; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
• CPC Class Codes: Y10T 436/119163 with aspirator of claimed structure
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

Devices and processes for the simultaneous transfer of liquids from a source container to a target container are disclosed. The source container includes a multitude of source sub-containers, and the target container includes a multitude of target sub-containers. The device includes a multitude of tubes arranged in a matrix, each tube having an entrance and exit.

Claims

1. A process of simultaneous transfer of liquids from a source container to a target container comprising:

providing a device including a multitude of tubes arranged in a matrix, each tube having an entry opening at an entry end and an exit opening at an exit end and at least one alignment member to maintain the pre-determined distances between the entry ends of the tubes and to maintain pre-determined distances between the exit ends of the tubes, wherein each of said tubes being capable of holding fluid by a phenomenon of capillarity, wherein the source container includes a multitude of source sub-containers the target container includes a multitude of target sub-containers, and wherein said matrix is vertically arranged with said exit openings directed upward and in fluid communication with said target container and said entry openings are directed downward and in fluid communication with said source container;

introducing the exit ends of the tubes into the target sub-containers;

introducing the entry ends of the tubes into the source sub-containers in an essentially vertical direction; and

progressively inclining the source container to an angle greater than 90°

, thereby transferring said liquid from said source container through the tubes to said target container.

2. The process according to claim 1, wherein the source container is a microtitration plate and the multitude of source sub-containers are wells;

wherein the target container is a capillary reservoir and the target sub-containers are canals; and

the process of filling the capillary reservoir from the microtitration plate includes;

introducing the exit ends of the tubes into the entry openings of the canals;

introducing the entry ends of the tubes into the wells in an essentially vertical direction; and

inclining the device, the reservoir, and the microtitration plate to an angle greater than 90°

.

3. The process according to claim 2, wherein the angle of incline of the device is between 90°

and 150°

.

4. The process according to claim 2, wherein the angle of incline of the device is between 110°

and 135°

.

5. The process according to claim 2, further including withdrawing the source container and withdrawing the target container from the device.

6. The process according to claim 5, further including forcing the flow of the liquids into the tubes after the source container has been withdrawn.

7. The process according to claim 6, wherein forcing the flow includes applying a silicone buffer which is heated to more than 50°

C. to the entry openings of the tubes.