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Albumin fusion proteins comprising GLP-1 polypeptides

  • US 7,141,547 B2
  • Filed: 02/11/2004
  • Issued: 11/28/2006
  • Est. Priority Date: 12/21/2001
  • Status: Active Grant
First Claim
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1. An albumin fusion protein comprising two or more tandemly oriented GLP-1 polypeptides, wherein said GLP-1 polypeptides are selected from wild-type GLP-1, GLP-1 fragments, and GLP-1 variants, fused to albumin comprising the amino acid sequence of SEQ ID NO:

  • 1038, an albumin fragment, or albumin variant thereof, wherein said albumin fragment or albumin variant increases the serum plasma half-life of the GLP-1 polypeptides, and wherein said fusion protein has GLP-1 activity.

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