Method and apparatus for assessing and treating atrial fibrillation risk

• US 7,142,912 B2
• Filed: 07/12/2002
• Issued: 11/28/2006
• Est. Priority Date: 07/12/2002
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kamath, Apurv, Wagner, Darrell O., Lovett, Eric G., Sweeney, Robert J., Cates, Adam W.
• Primary Examiner(s): Evanisko, George R.
• Assistant Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US10/194,435
• Publication Number:
  US 20040010291A1
• Time in Patent Office: 1,600 Days
• Field of Search: 600/515, 600/518, 600/519, 607/4, 607/5, 607/9, 607/14
• US Class Current: 607/4
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A method and apparatus for assessing the risk of atrial fibrillation in a patient by calculating the relative frequency of short and long intervals between successive heart beats during sinus rhythm is presented. An imbalance of short over long sinus intervals has been found to indicate a higher risk of atrial fibrillation. An implantable cardiac device may be configured to automatically deliver interventional therapy to restore sinus interval balance when such an imbalance is detected.

Claims

1. A cardiac device, comprising:

a cardiac sensing channel; and

a controller programmed to measure sinus intervals as the time intervals between successive heart beats during sinus rhythm as detected through the sensing channel;

wherein the controller is further programmed to assess atrial fibrillation risk by determining the relative frequencies of short and long sinus intervals as compared with an average sinus interval over a specified period of time.

2. The device of claim 1 wherein the controller is programmed to assess atrial fibrillation risk by counting the numbers of short and long sinus intervals over a specified period of time, where a sinus interval is classified as short or long by comparing the sinus interval with a moving average of previous sinus intervals, and wherein an increased risk of atrial fibrillation is determined to exist if the percentage of short sinus intervals is greater than the percentage of long sinus intervals and greater than a specified minimum threshold value.

3. The device of claim 2 wherein a sinus interval is classified as short or long by determining the ratio of the sinus interval to the moving average of previous sinus intervals and then determining if the ratio is within a short interval ratio range or long interval ratio range, respectively.

4. The device of claim 3 wherein the short interval ratio range is between 0.2 and 0.78, and the long interval ratio range is between 1.2 and 2.0.

5. The device of claim 2 wherein the specified minimum threshold value is 0.002.

6. The device of claim 1 wherein the sinus interval is measured as an RR interval measured as the time between ventricular senses.

7. The device of claim 1 wherein the sinus interval is a PP interval measured as the time between atrial senses.

8. The device of claim 1 further comprising a stimulation channel and wherein the controller is further programmed to cause the stimulation channel to deliver an atrial pace following a ventricular sense when the ventricles are refractory to lengthen the RR interval between successive ventricular contractions after detecting an increased risk of atrial fibrillation.

9. The device of claim 1 further comprising a stimulation channel and wherein the controller is further programmed to lengthen the RR interval after detecting an increased risk of atrial fibrillation by causing the stimulation channel to deliver electrical stimulation of the AV node or parasympathetic nerves innervating the AV node.

10. The device of claim 1 further comprising a stimulation channel and wherein the controller is further programmed to lengthen the PP and RR intervals after detecting an increased risk of atrial fibrillation by causing the stimulation channel to deliver electrical stimulation parasympathetic nerves innervating the SA node.

11. The device of claim 1 further comprising a stimulation channel and wherein the controller is further programmed, when an increased risk of atrial fibrillation is detected, to cause the stimulation channel to pace the atria or ventricles at a slowly increasing rate while maintaining an interval ratio near a value of one over a period of time up to a maximum rate limit, and then increase the pacing interval to an intrinsic base rate quickly enough to cause a long RR interval as compared with the short-term average.

12. A method for operating a cardiac device, comprising:

measuring sinus intervals as the time intervals between successive heart beats during sinus rhythm; and

assessing atrial fibrillation risk by determining the relative frequencies of short and long sinus intervals as compared with an average sinus interval over a specified period of time.

13. The method of claim 12 further comprising assessing atrial fibrillation risk by counting the numbers of short and long sinus intervals over a specified period of time, where a sinus interval is classified as short or long by comparing the sinus interval with a moving average of previous sinus intervals, and wherein an increased risk of atrial fibrillation is determined to exist if the percentage of short sinus intervals is greater than the percentage of long sinus intervals and greater than a specified minimum threshold value.

14. The method of claim 13 wherein a sinus interval is classified as short or long by determining the ratio of the sinus interval to the moving average of previous sinus intervals and then determining if the ratio is within a short interval ratio range or long interval ratio range, respectively.

15. The method of claim 14 wherein the short interval ratio range is between 0.2 and 0.78, and the long interval ratio range is between 1.2 and 2.0.

16. The method of claim 12 wherein the specified minimum threshold value is 0.002.

17. The method of claim 12 wherein the sinus interval is measured as an RR interval measured as the time between ventricular senses.

18. The method of claim 12 wherein the sinus interval is a PP interval measured as the time between atrial senses.

19. The method of claim 12 further comprising delivering an atrial pace following a ventricular sense when the ventricles are refractory to lengthen the RR interval between successive ventricular contractions after detecting an increased risk of atrial fibrillation.

20. The method of claim 12 further comprising lengthening the RR interval after detecting an increased risk of atrial fibrillation by electrical stimulation of the AV node or parasympathetic nerves innervating the AV node.

21. The method of claim 12 further comprising:

when an increased risk of atrial fibrillation is detected, pacing the atria or ventricles at a slowly increasing rate while maintaining an interval ratio near a value of one over a period of time up to a maximum rate limit; and

increasing the pacing interval to an intrinsic base rate quickly enough to cause a long RR interval as compared with the short-term average.

22. The method of claim 12 further comprising lengthening the RR and PP intervals after detecting an increased risk of atrial fibrillation by electrical stimulation of parasympathetic nerves innervating the SA node.