Noninvasive blood pressure monitoring system

• US 7,144,372 B2
• Filed: 02/27/2003
• Issued: 12/05/2006
• Est. Priority Date: 01/29/2003
• Status: Active Grant

• Current Assignee: Boita, Inc., HealthSTATS International Pte Ltd.
• Original Assignee: HealthSTATS International Pte Ltd.
• Inventors: Peh, Wee Leng, Ng, Kim-Gau, Chua, Ngak Kwong
• Primary Examiner(s): Marmor, Charles A
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US10/376,655
• Publication Number:
  US 20040147847A1
• Time in Patent Office: 1,377 Days
• Field of Search: 600/485, 600/486
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Abstract

The preferred embodiment of the present invention comprises a single microprocessor-based interface that connects between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor or module. The interface effectively emulates an IBP transducer in such a way that the IBP monitor sees the interface as if it were a regular IBP transducer from a fluid-filled blood pressure monitoring line. It receives the signal from an NIBP sensor and determines the blood pressure corresponding to the signal. It accepts the excitation voltage provided by the IBP monitor. From the excitation voltage and a known transducer sensitivity which the IBP monitor is configured to work with, the interface emulates the IBP transducer output signal corresponding to the blood pressure. The interface also emulates the input and output impedances of the IBP transducer which the IBP monitor is configured to work with. Zeroing of the interface with the IBP monitor can be easily performed in a way that is similar to that for a fluid-filled system. A noninvasive system comprising a suitable NIBP sensor and this interface can be used as an alternative to the fluid-filled monitoring line.

Claims

1. An interface configured to connect between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor comprising

a first input configured to receive a measurement signal indicative of the NIBP of a subject;

a second input configured to receive a transducer excitation signal provided by an IBP monitor;

at least one processor(s) configured to receive said measurement signal and said excitation signal and emulate an output signal indicative of the IBP of a subject according to predetermined instructions; and

where the differential voltage of said output signal depends on said excitation signal, a predetennined or selectable transducer sensitivity, and said measurement signal; and

an output configured to provide said output signal in a form suitable for input to said IBP monitors, including a digital-to-analog converter (DAC) to receive output signal from said processor(s), and said DAC is configured according to predetermined instructions such that its full-scale output voltage range includes the voltage range corresponding to a predetermined maximum pressure range of the NIBP of a subject.

2. An interface as claimed in claim 1 wherein

said digital-to-analog converter (DAC) is a configurable bipolar DAC;

said processor(s) is further configured to configure said DAC; and

said DAC is further configured to optimize the resolution of said full-scale output voltage range.

3. An interface as claimed in claim 2 wherein said full-scale voltage range is proportional to the result of the following mathematical expression:

V_EXC×

SENS×

(P_MAX−

P_MIN)

.

4. An interface as claimed in claim 1 wherein said processor(s) is further configured to increase the number of digital values for said output signal by interpolation so as to improve the smoothness of the signal that is input to an IBP monitor.

5. An interface as claimed in claim 4 wherein said interpolation includes linear interpolation, nonlinear interpolation, or a combination of the two.

6. An interface configured to connect between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor comprising

a first input configured to receive a measurement signal indicative of the NIBP of a subject;

a second input configured to receive a transducer excitation signal provided by an IBP monitor;

at least one processor(s) configured to receive said measurement signal and said excitation signal and emulate an output signal indicative of the IBP of a subject according to predetermined instructions; and

an output configured to provide said output signal in a form suitable for input to an IBP monitor;

wherein said processor(s) is configured such that a user can select from a predetermined range of processing options.

7. An interface as claimed in claim 6 wherein said processor(s) comprises an embedded microprocessor system, a personal computer, or a combination of the two.

8. An interface as claimed in claim 7 wherein said processing options include an embedded microprocessor system, a personal computer, and a combination of the two.

9. An interface as claimed in claim 7 wherein said combination is configured such that said embedded microprocessor system and said personal computer work independently such that said interface can receive said measurement signal and said excitation signal and can generate an output signal indicative of the IBP of a subject according to predetermined instructions without said personal computer being used, and said personal computer forms an optional part of said interface and is used for additional signal and data processing.

10. An interface as claimed in claim 7, wherein said combination is configured such that both said embedded microprocessor system and said personal computer cooperate to receive said measurement signal and said excitation signal and to generate an output signal indicative of the IBP of a subject according to predetermined instructions.

11. An interface configured to connect between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor comprising

a first input configured to receive a measurement signal indicative of the NIBP of a subject;

a second input configured to receive a transducer excitation signal provided by an IBP monitor;

at least one processor(s) configured to receive said measurement signal and said excitation signal and emulate an output signal indicative of the IBP of a subject according to predetermined instructions; and

an output configured to provide said output signal in a form suitable for input to an IBP monitor;

wherein said second input is configured to provide an input impedance that is within a predetermined range,

wherein said processor(s) and said second input are configured such that a user can select the input impedance.

12. An interface as claimed in claim 11 wherein said predetermined range is greater than 200 ohms.

13. An interface as claimed in claim 11 wherein said second input includes one or more resistors between the input terminals corresponding to said input impedance.

14. An interface configured to connect between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor comprising a first input configured to receive a indicative of the NIBP of a subject;

a second input configured to receive a transducer excitation signal provided by an IBP monitor;

configured to determine the differential voltage of said excitation signal; and

configured to determine the midpoint voltage of said excitation signal;

at least one processor(s) configured to receive said measurement signal and said differential voltage and emulate an output signal indicative of the IBP of a subject according to predetermined instructions; and

an output configured to receive said midpoint voltage and configured to provide said output signal in a form suitable for input to an IBP monitor; and

such that the midpoint of said output signal is substantially similar to that of said midpoint voltage.

15. An interface as claimed in claim 14 wherein said second input includes a voltage divider, a differential amplifier, or a combination of the two configured to sense and condition said differential voltage.

16. An interface as claimed in claim 15 wherein said processor(s) is configured to receive both positive and negative ranges of said conditioned differential voltage through a circuit that includes an analog-to-digital converter (ADC).

17. An interface as claimed in claim 16 wherein said analog-to-digital converter (ADC) is a bipolar ADC.

18. An interface as claimed in claim 14, wherein said second input includes a voltage divider or a combination of a voltage divider and a differential amplifier, configured to sense and condition said midpoint voltage.

19. An interface configured to connect between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor comprising

a first input configured to receive a measurement signal indicative of the NIBP of a subject;

a second input configured to receive a transducer excitation signal provided by an IBP monitor;

at least one processor(s) configured to receive said measurement signal and said excitation signal and emulate an output signal indicative of the IBP of a subject according to predetermined instructions; and

an output configured to determine the output differential voltage for said output signal; and

having at least two terminals configured to provide said output signal in a form suitable for input to an IBP monitor;

wherein said second input, said processor(s) and said output are configured such that the voltage level of each of said two terminals is substantially similar to that produced by an IBP transducer for the same pressure variations in a subject.

20. An interface as claimed in claim 19 configured such that the output signal at said terminals is obtained by adding the midpoint voltage of said excitation signal with respect to the electrical ground of said interface, to the midpoint of said output differential voltage, this output differential voltage being the result of the following mathematical expression:

V_EXC×

SENS×

P

.

21. An interface as claimed in claim 20 wherein said output includes a summing amplifier to add the midpoint voltages.

22. An interface as claimed in claim 19 configured such that the output signal at said terminals is obtained by adding the midpoint voltage of said excitation signal with respect to the electrical ground of said interface, to the voltage at either terminal for said output differential voltage, this output differential voltage being the result of the following mathematical expression:

V_EXC×

SENS×

P

.

23. An interface as claimed in claim 22 wherein said output is configured such that said midpoint voltage of said excitation signal is added to the voltage at either terminal for said output differential voltage by a summing amplifier.

24. An interface configured to connect between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor comprising

a first input configured to receive a measurement signal indicative of the NIBP of a subject;

a second input configured to receive a transducer excitation signal provided by an IBP monitor;

configured to determine the differential voltage of said excitation signal; and

configured to determine the midpoint voltage of said excitation signal;

at least one processor(s) configured to receive said measurement signal and said differential voltage and emulate an output signal indicative of the IBP of a subject according to predetermined instructions;

an output configured to receive said midpoint voltage and configured to provide said output signal in a form suitable for input to an IBP monitor; and

such that the midpoint of said output signal is substantially similar to that of said midpoint voltage;

said processor(s) and output are configured to provide an output differential voltage in relation to said measurement signal in a form suitable for input to an IBP monitor; and

said output is configured to add said midpoint voltage to the midpoint of said output differential voltage.