Endovascular prosthesis, system and method

• US 7,144,421 B2
• Filed: 11/06/2003
• Issued: 12/05/2006
• Est. Priority Date: 11/06/2003
• Status: Active Grant

• Current Assignee: Mitsubishi Chemical Corporation (Mitsubishi Chemical Group Corp.)
• Original Assignee: Jeffrey P. Carpenter, Judith T. Carpenter
• Inventors: Carpenter, Jeffrey P., Carpenter, Judith T.
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): Sweet, Thomas J.
• Application Number:
  US10/702,864
• Publication Number:
  US 20050102018A1
• Time in Patent Office: 1,125 Days
• Field of Search: 623/1.27, 623/1.3, 623/1.31, 623/1.35, 623/1.25
• US Class Current: 623/1.31
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2002/061 provided with means for allowing access to secondary lumens
• CPC Class Codes: A61F 2002/067 modular
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers

Abstract

An endovascular prosthesis comprising a first end section, a second end section and a midsection. The midsection has a diameter less than the diameter of the first end section and the second end section. At least the first end section and the second end section have lateral support preferably in the form of a stent which may also act as anchoring. The reduced diameter midsection is provided with at least one side port which is adapted to be connected to a branch endograft to provide a connection between the side port and the native branch artery. The side ports are arranged to correspond with the native branch arteries and are provided with radiographic markers at their proximal and distal ends. The side ports with the radiographic markers provide an effective means of making the connection to the native branch by a branch endograft without having to align the side ports exactly to the branch arteries and without kinking of the side ports.

Claims

1. An endovascular prosthesis, comprising:

a first end section having a longitudinally extending central lumen and means for laterally supporting said first end section;

a second end section having a longitudinally extending central lumen and means for laterally supporting said second end section;

a midsection formed between said first end section and said second end section and provided with a longitudinally extending central lumen in communication with said longitudinally extending central lumens of said first end section and said second end section;

said midsection having a diameter less than a diameter of said first end section and less than a diameter of said second end section;

said midsection being provided with at least one side-port adapted to be connected to a branch endograft; and

wherein said side-port has a longitudinal axis which is angled at less than 90 degrees with respect to the longitudinal direction of the central lumen of said midsection.

2. An endovascular prosthesis in accordance with claim 1 wherein said midsection includes a tapered portion extending from said first end section.

3. An endovascular prosthesis in accordance with claim 1 wherein said midsection includes a tapered portion extending from said second end section.

4. An endovascular prosthesis in accordance with claim 1 wherein said midsection is provided with a plurality of side-ports.

5. An endovascular prosthesis in accordance with claim 4 wherein said side-ports are positioned on said midsection in an arrangement approximating an arrangement of native branch vessels.

6. An endovascular prosthesis in accordance with claim 4 wherein said side-ports and their arrangement allow for accurate branch endograft placement without kinking despite variations in location of native branch vessels.

7. An endovascular prosthesis in accordance with claim 4 wherein each of said side-ports includes a proximal end attached to said midsection and a distal end and wherein each of said proximal and distal ends is provided with a radiologic marker.

8. An endovascular prosthesis in accordance with claim 7 wherein said plurality of side ports are geometrically arranged on the midsection to allow radiological identification of side ports.

9. An endovascular prosthesis in accordance with claim 4 which includes four side ports, one for the celiac artery, one for the superior mesenteric artery and two ports for the renal arteries.

10. An endovascular prosthesis in accordance with claim 9 wherein said ports for said renal arteries are arranged laterally and said port for said celiac artery is arranged centrally and positioned nearer to said first end section.

11. An endovascular prosthesis in accordance with claim 4 including three side ports arranged linearly on said midsection, one being for the innominate artery, one being for the left carotid artery and one being for the left subclavian artery.

12. An endovascular prosthesis in accordance with claim 4 wherein said plurality of side ports are each slanted in the direction of branch arteries to which they are intended to be connected.

13. An endovascular prosthesis in accordance with claim 4 wherein said plurality of side-ports are each comprised of a hollow tube having a length which is short in comparison to the distance to a native branch artery to which it is intended to be connected, said plurality of side-ports having a longitudinal axis which is slanted in the direction of branch arteries to which they are intended to be connected by branch endografts, said hollow tubular side-ports being connected to said midsection in an impervious manner, and said plurality of side-ports each being provided with radiological markers proximally and distally.

14. An endovascular prosthesis in accordance with claim 1 wherein said side-port includes a proximal end connected to said midsection and a distal end, said proximal and distal ends of said side-port being provided with radiologic markers.

15. An endovascular prosthesis in accordance with claim 1 wherein said means for laterally supporting said first end section and said second end section are stents.

16. An endovascular prosthesis in accordance with claim 15 wherein said sterns are located on an outer surface of said first and second end sections.

17. An endovascular prosthesis in accordance with claim 1 wherein said midsection is provided with lateral support means.

18. An endovascular prosthesis in accordance with claim 17 wherein said lateral support means of said first and second end sections and said midsection are located on an outer surface of said prosthesis.

19. An endovascular prosthesis in accordance with claim 17 wherein said lateral support means for said first and second end sections and said midsection are formed within a wall of said prosthesis.

20. An endovascular prosthesis in accordance with claim 1 wherein said means for laterally supporting said first end section and said second end section are resilient stents.

21. An endovascular prosthesis in accordance with claim 1 wherein said means for laterally supporting said first end section and said second end section are resilient stents which act as anchors.

22. An endovascular prosthesis in accordance with claim 21 wherein at least said first end section is provided with anchoring means in addition to said means for laterally supporting said first end section.

23. An endovascular prosthesis in accordance with claim 1

wherein the diameter of said second end section is less than the diameter of said first end section.

24. An endovascular prosthesis in accordance with claim 1 wherein said at least one side port is slanted in the direction of a branch artery to which it is intended to be connected by said branch endograft.

25. An endovascular prosthesis in accordance with claim 1 wherein said at least one side-port is comprised of a hollow tube having a length which is short in comparison to the distance to a native branch artery to which it is intended to be connected, said at least one side-port having a longitudinal axis which is slanted in the direction of a branch artery to which it is intended to be connected by said branch endograft, said hollow tubular side-port being connected to said midsection in an impervious manner, and said side-port being provided with a radiological markers proximally and distally.

26. An endovasculr prosthesis, comprising:

a first end section having a longitudinally extending central lumen and means for laterally supporting said first end section;

a second end section having a longitudinally extending central lumen and means for laterally supporting said second end section;

a midsection formed between said first end section and said second end section and provided with a longitudinally extending central lumen in communication with said longitudinally extending central lumens of said first end section and said second end section;

said midsection having a diameter less than a diameter of said first end section and less than a diameter of said second end section;

wherein said midsection includes a tapered portion extending from said first end section; and

including a plurality of side ports wherein at least one side port is located on said tapered portion and at least one other side port is located on said midsection below said tapered portion.

27. An endovascular prosthetic system, comprising:

a sheath;

a central tube located within said sheath, said central tube adapted to receive a guide wire;

a pusher element within said sheath;

a tip element, including a conical forward and a conical rearward section of said tip element, a diameter of said tip element being larger than said sheath;

wherein an endovascular prosthesis may be positioned within said sheath and between said pusher and said tip for insertion into the vasculature of a body; and

said endovascular prothesis including a midsection formed between two end sections, said midsection being of a smaller diameter than the diameters of said end sections and being provided with at least one side port adapted to be connected to a branch endograft.

28. A method of grafting using an endovascular prosthesis, comprising the steps of:

inserting a catheter into vasculature having at least one native branch;

releasing from said catheter an endovascular prosthesis having a midsection of reduced diameter with at least one side port formed on the midsection, said side port being provided with radiologic markers at its proximal and distal ends; and

visualizing the radiologic markers on the proximal and distal ends of the side port to aid in placing a guide wire and a branch endograft for a connection between said side port and said native branch artery.

29. A method of grafting using an endovascular prosthesis in accordance with claim 28 wherein said endovascular prosthesis is provided with a resilient stent which expands said endovascular prosthesis upon release from said catheter and wherein said endovascular prosthesis is provided with a first end section and a second end section with said midsection therebetween and wherein at least one of said first end section and said second end section expands to engage an artery wall.

30. A method of grafting using an endovascular prosthesis in accordance with claim 28 wherein said endovascular prosthesis is provided with a resilient stent which expands said endovascular prosthesis upon release from said catheter and wherein said endovascular prosthesis is provided with a first end section and a second end section with said midsection therebetween and wherein at least one of said first end section and said second end section expands to engage another endovascular prosthesis.

31. A method of grafting using an endovascular prosthesis, comprising the steps of:

inserting a catheter into vasculature having a plurality of native branches;

releasing from said catheter an endovascular prosthesis having a midsection of reduced diameter with a plurality of side ports formed on the midsection, said side ports being arranged to correspond generally with the arrangement of said plurality of native branches, each of said side ports being provided with a radiologic marker at its proximal and distal ends; and

visualizing the radiologic markers on the proximal and distal ends of the side ports to aid in placing guide wires and branch endografts to form a connection between the distal end of each side port and a corresponding native branch artery.

32. A method of grafting using an endovascular prosthesis in accordance with claim 31 wherein said plurality of side ports formed on the midsection fold within the length of the midsection when said endovascular prosthesis is within said catheter.

33. A method of grafting using an endovascular prosthesis in accordance with claim 31 wherein said endovascular prosthesis is provided with a resilient stent which expands said endovascular prosthesis upon release from said catheter and wherein said endovascular prosthesis is provided with a first end section and a second end section with said midsection therebetween and wherein at least one of said first end section and said second end section expands to engage an artery wall.

34. A method of grafting using an endovascular prosthesis in accordance with claim 31 wherein said endovascular prosthesis is provided with a resilient stent which expands said endovascular prosthesis upon release from said catheter and wherein said endovascular prosthesis is provided with a first end section and a second end section with said midsection therebetween and wherein at least one of said first end section and said second end section expands to engage another endovascular prosthesis.

35. An endovascular prosthesis, comprising:

a first end section having a longitudinally extending central lumen and means for laterally supporting said first end section by radial expansion;

a second end section having a longitudinally extending central lumen and means for laterally supporting said second end section by radial expansion;

a midsection formed between said first end section and said second end section and provided with a longitudinally extending central lumen in communication with said longitudinally extending central lumens of said first end section and said second end section;

said midsection having a diameter less than a diameter of said first end section and less than a diameter of said second end section when said means for laterally supporting said first end section and means for laterally supporting said second end section are not radially expanded; and

said midsection being provided with at least one side-port adapted to be connected to a branch endograft; and

wherein said side-port has a longitudinal axis which is angled at less than 90 degrees with respect to the longitudinal direction of the central lumen of said midsection.

36. An endovascular prosthesis in accordance with claim 35 wherein said midsection includes a tapered portion extending from said first end section.

37. An endovascular prosthesis in accordance with claim 35 wherein said midsection includes a tapered portion extending from said second end section.

38. An endovascular prosthesis in accordance with claim 35 wherein said midsection is provided with a plurality of side-ports.

39. An endovascular prosthesis in accordance with claim 38 wherein said side-ports are positioned on said midsection in an arrangement approximating an arrangement of native branch vessels.

40. An endovascular prosthesis in accordance with claim 38 wherein said side-ports and their arrangement allow for accurate branch endograft placement without kinking despite variations in location of native branch vessels.

41. An endovascular prosthesis in accordance with claim 38 wherein each of said side-ports includes a proximal end attached to said midsection and a distal end and wherein each of said proximal and distal ends is provided with a radiologic marker.

42. An endovascular prosthesis in accordance with claim 41 wherein said plurality of side ports are geometrically arranged on the midsection to allow radiological identification of side ports.

43. An endovascular prosthesis in accordance with claim 38 which includes four side ports, one for the celiac artery, one for the superior mesenteric artery and two ports for the renal arteries.

44. An endovascular prosthesis in accordance with claim 43 wherein said ports for said renal arteries are arranged laterally and said port for said celiac artery is arranged centrally and positioned nearer to said first end section.

45. An endovascular prosthesis in accordance with claim 38 including three side ports arranged linearly on said midsection, one being for the innominate artery, one being for the left carotid artery and one being for the left subclavian artery.

46. An endovascular prosthesis in accordance with claim 38 wherein said plurality of side ports are each slanted in the direction of branch arteries to which they are intended to be connected.

47. An endovascular prosthesis in accordance with claim 38 wherein said plurality of side-ports are each comprised of a hollow tube having a length which is short in comparison to the distance to a native branch artery to which it is intended to be connected, said plurality of side-ports having a longitudinal axis which is slanted in the direction of branch arteries to which they are intended to be connected by branch endografts, said hollow tubular side-ports being connected to said midsection in an impervious manner, and said plurality of side-ports each being provided with radiological markers proximally and distally.

48. An endovascular prosthesis in accordance with claim 35 wherein said side-port includes a proximal end connected to said midsection and a distal end, said proximal and distal ends of said side-port being provided with radiologic markers.

49. An endovascular prosthesis in accordance with claim 35 wherein said means for laterally supporting said first end section and said second end section are stents.

50. An endovascular prosthesis in accordance with claim 49 wherein said sterns are located on an outer surface of said first and second end sections.

51. An endovascular prosthesis in accordance with claim 35 wherein said midsection is provided with lateral support means.

52. An endovascular prosthesis in accordance with claim 51 wherein said lateral support means of said first and second end sections and said midsection are located on an outer surface of said prosthesis.

53. An endovascular prosthesis in accordance with claim 51 wherein said lateral support means for said first and second end sections and said midsection are formed within a wall of said prosthesis.

54. An endovascular prosthesis in accordance with claim 35 wherein said means for laterally supporting said first end section and said second end section are resilient stents.

55. An endovascular prosthesis in accordance with claim 35 wherein said means for laterally supporting said first end section and said second end section are resilient stents which act as anchors.

56. An endovascular prosthesis in accordance with claim 55 wherein at least said first end section is provided with anchoring means in addition to said means for laterally supporting said first end section.

57. An endovascular prosthesis in accordance with claim 35 wherein the diameter of said second end section is less than the diameter of said first end section.

58. An endovascular prosthesis in accordance with claim 35 wherein said at least one side port is slanted in the direction of a branch artery to which it is intended to be connected by said branch endograft.

59. An endovascular prosthesis in accordance with claim 35 wherein said at least one side port is comprised of a hollow tube having a length which is short in comparison to the distance to a native branch artery to which it is intended to be connected, said at least one side port having a longitudinal axis which is slanted in the direction of a branch artery to which it is intended to be connected by said branch endograft, said hollow tubular side-port being connected to said midsection in an impervious manner, and said side-port being provided with a radiological markers proximally and distally.

60. An endovascular prosthesis, comprising:

a first end section having a longitudinally extending central lumen and means for laterally supporting said first end section by radial expansion;

a second end section having a longitudinally extending central lumen and means for laterally supporting said second end section by radial expansion;

a midsection formed between said first end section and said second end section and provided with a longitudinally extending central lumen in communication with said longitudinally extending central lumens of said first end section and said second end section;

said midsection having a diameter less than a diameter of said first end section and less than a diameter of said second end section when said means for laterally supporting said first end section and means for laterally supporting said second end section are not radially expanded;

wherein said midsection includes a tapered portion extending from said first end section; and

including a plurality of side ports wherein at least one side port is located on said tapered portion and at least one other side port is located on said midsection below said tapered portion.