Drug-eluting stent and methods of making the same
First Claim
1. A drug-eluting stent delivery system for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel, comprising:
- a pattern of struts interconnected to form a structure capable of contacting the walls of a body lumen to maintain the patency of the vessel,wherein a polymeric sleeve, fabricated as a prepatterned tube comprising polymer elements, is loaded with at least one therapeutic drug for the release thereof at a treatment site, the polymeric sleeve being attached to at least a portion of an outside surface area of the stent structure andwherein the prepatterning enables the detachment of the polymer elements upon stent expansion,wherein the polymeric sleeve includes a plurality of four-sided, filament strands attached to the surface of the stent, andwherein a barrier coating layer is disposed on three sides of the plurality of four-sided filament strands to enable drug elution along the fourth side.
1 Assignment
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Accused Products
Abstract
An intravascular stent having a prefabricated, patterned polymeric sleeve for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel is disclosed. The polymeric sleeve is attached to at least a portion of an outside surface area of the stent structure. Alternatively, a plurality of individual microfilament strands are longitudinally attached to an outer surface of a stent structure in a spaced apart orientation and loaded with at least one therapeutic drug for the release thereof at a treatment site. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. Methods for making the same are also disclosed.
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Citations
16 Claims
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1. A drug-eluting stent delivery system for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel, comprising:
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a pattern of struts interconnected to form a structure capable of contacting the walls of a body lumen to maintain the patency of the vessel, wherein a polymeric sleeve, fabricated as a prepatterned tube comprising polymer elements, is loaded with at least one therapeutic drug for the release thereof at a treatment site, the polymeric sleeve being attached to at least a portion of an outside surface area of the stent structure and wherein the prepatterning enables the detachment of the polymer elements upon stent expansion, wherein the polymeric sleeve includes a plurality of four-sided, filament strands attached to the surface of the stent, and wherein a barrier coating layer is disposed on three sides of the plurality of four-sided filament strands to enable drug elution along the fourth side. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of making a drug-eluting stent delivery system for controlled release of therapeutic drug(s) and for delivery of the therapeutic drug(s) in localized drug therapy in a blood vessel, comprising:
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forming a pattern of struts that form a stent capable of contacting the walls of a body lumen to maintain the patency of the vessel, wherein at least a portion of the outside surface of the stent surface attaches to a polymeric sleeve that is fabricated as a prepatterned tube comprising a plurality of four-sided, filament strands attached to the surface of the stent, and is loaded with at least one therapeutic drug for the release thereof at a treatment site, wherein the prepatterning enables the detachment of the filament strands upon stent expansion, and wherein a barrier coating layer is disposed on three sides of the plurality of four-sided filament strands to enable drug elution along the fourth side. - View Dependent Claims (14, 15, 16)
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Specification