Acidic phenolic disinfectant compositions

• US 7,144,846 B2
• Filed: 05/11/2004
• Issued: 12/05/2006
• Est. Priority Date: 05/11/2004
• Status: Expired due to Term

• Current Assignee: American Sterilizer Company (Steris Corporation)
• Original Assignee: Steris Inc (Steris Corporation)
• Inventors: Tirey, Jason F., Klein, Daniel A., Kaiser, Herbert J., Keller, Shahin, Kaiser, Nancy E.
• Primary Examiner(s): BOYER, CHARLES I
• Application Number:
  US10/843,600
• Publication Number:
  US 20050256018A1
• Time in Patent Office: 938 Days
• Field of Search: 510/130, 510/131, 510/132, 510/138, 510/161, 510/191, 510/238, 510/253, 510/386, 510/387, 510/388, 510/477, 510/432
• US Class Current: 510/161
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/08 Oxygen or sulfur directly attached to an aromatic ring system
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 41/04 Sulfonic acids; Derivatives thereof
• CPC Class Codes: C11D 3/2006 Monohydric alcohols
• CPC Class Codes: C11D 3/2034 aromatic
• CPC Class Codes: C11D 3/2041 Dihydric alcohols
• CPC Class Codes: C11D 3/2075 Carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

A low pH disinfectant composition comprises an aqueous composition of a phenolic compound, an organic acid, and/or a dispersing surfactant and/or solvent. The disinfectant solution can be concentrated, or more preferably diluted ready to use, and is very effective in eradicating fungi including Aspergillus niger.

Claims

1. A ready to use aqueous disinfectant composition, comprising:

water, wherein all parts are based upon 100 parts by weight of water;

a total of from about 0.005 to 0.3 parts by weight of two or more phenolic compounds, wherein at least one of the phenolic compounds is an aromatic substituted phenol and wherein at least one of the phenolic compounds is an aliphatic substituted phenol;

a total of from 3.0 to 30 parts by weight of an alcohol, wherein said alcohol is an alkyl alcohol having from 1 to about 10 carbon atoms or a glycol alcohol having from 2 to about 12 carbon atoms or a combination thereof; and

a total of from 0.5 to about 30 parts by weight of two or more organic carboxylic acids, wherein at least one of the organic acids consists of an aliphatic monocarboxylic acid having from 1 to about 10 carbon atoms, and wherein the aqueous disinfectant composition has a pH from about 2 to 5.

2. The ready to use aqueous disinfectant composition according to claim 1, wherein the amount of said two or more phenolic compounds is from about 0.007 to 0.3 parts by weight.

3. The ready to use aqueous disinfectant composition according to claim 2, wherein the amount of said two or more organic carboxylic acids is from about 2 to about 20 parts by weight, and wherein said organic carboxylic acids each have a pKa from about 1 to about 6.5;

wherein the composition further includes a surfactant, wherein said surfactant is an anionic surfactant, a cationic surfactant, a nonionic surfactant, or an amphotenc surfactant, or combinations thereof, and wherein the amount of said surfactant is from about 0.01 to about 15 parts by weight.

4. The ready to use aqueous disinfectant composition according to claim 3, wherein said aliphatic substituted phenol has at least one substituent group comprising a hydrocarbon group having from 1 to about 20 carbon atoms, wherein said organic acid consisting of the aliphatic monocarboxylic acid is formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, or combinations thereof, and wherein the amount of said two or more organic carboxylic acids is from about 5 to about 17 parts by weight.

5. The ready to use aqueous disinfectant composition according to claim 4, wherein said aliphatic substituted phenol is p-chloro-m-xylenol or p-t-amylphenol or a combination thereof, wherein the aromatic substituted phenol is o-phenylphenol, o-benzyl-p-chlorophenol or 5-chloro-2-(2,4-dichlorophenoxy)phenol, or combinations thereof, and wherein the amount of phenolic compounds is from about 0.01 to about 0.2 parts by weight.

6. The ready to use aqueous disinfectant composition according to claim 5, wherein said alcohol is isopropyl alcohol or n-propyl alcohol or combinations thereof in amount of from about 1 to about 20 parts by weight, and wherein the amount of said surfactant is from about 0.05 to about 3 parts by weight.

7. The ready to use aqueous disinfectant composition of claim 1, which is capable of a Log reduction of at least 4.0 with regard to Aspergillus niger.

8. The ready to use aqueous disinfectant composition of claim 5, which is capable of a Log reduction of at least 6.0 with regard to Aspergillus niger.

9. The ready to use aqueous disinfectant composition of claim 1, wherein at least one of the organic carboxylic acids consists of a hydroxyl group containing carboxylic acid.

10. The ready to use aqueous disinfectant composition of claim 9, wherein the phenolic compounds comprise o-benzyl-p-chlorophenol and p-t-amylphenol.

11. The ready to use aqueous disinfectant composition according to claim 9, which is capable of a Log reduction of at least 4.0 with regard to Aspergillus niger.

12. The ready to use aqueous disinfectant composition according to claim 10, which is capable of a Log reduction of at least 6.0 with regard to Aspergillus niger.

13. The ready to use aqueous disinfectant composition according to claim 1, which has been irradiated.

14. The ready to use aqueous disinfectant composition according to claim 5, which has been irradiated.

15. A process for preparing a ready to use aqueous disinfectant phenolic composition, comprising the steps of:

adding and mixing water, two or more phenolic compounds, at least one alcohol; and

two or more organic carboxylic acids;

the total amount of said two or more phenolic compounds being from about 0.005 to 0.3 parts per 100 parts by weight of water, wherein at least one of the phenolic compounds is an aromatic substituted phenol and wherein at least one of the phenolic compounds is an aliphatic substituted phenol, the total amount of said alcohol being from 3.0 to 30 parts per 100 parts by weight of water, wherein said alcohol is an alkyl alcohol having from 1 to about 10 carbon atoms or a glycol alcohol having from 2 to about 12 carbon atoms or a combination thereof, and

a total of from 0.5 to about 30 parts by weight of said two or more organic carboxylic acids per 100 parts by weight of water, wherein at least one of the organic acids consists of an aliphatic monocarboxylic acid having from 1 to about 10 carbon atoms, and wherein said aqueous disinfectant composition has a pH of from about 2 to 5.

16. The process according to claim 15, wherein the amount of said two or more phenolic compounds is from about 0.007 to about 0.3 parts by weight.

17. The process according to claim 16, wherein the amount of said two or more organic carboxylic acids is from about 2 to about 20 parts by weight, and wherein said organic carboxylic acids each have a pKa from about 1 to about 6.5;

wherein said phenolic composition further includes a surfactant, wherein said surfactant is an anionic surfactant, a cationic surfactant, a nonionic surfactant, or an amphoteric surfactant, or combinations thereof, and wherein the amount of said surfactant is from about 0.01 to about 15 parts by weight per 100 parts by weight of water.

18. The process according to claim 17, wherein said aliphatic substituted phenol has at least one substituent group comprising a hydrocarbon group having from 1 to about 20 carbon atoms, wherein said organic acid consisting of the aliphatic monocarboxylic acid is formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, or combinations thereof, and wherein the amount of said two or more organic carboxylic acids is from about 5 to about 17 parts by weight.

19. The process according to claim 18, wherein said aliphatic substituted phenol is p-chloro-m-xylenol, or p-t-amylphenol, or a combination thereof, wherein the aromatic substituted phenol is o-phenylphenol, o-benzyl-p-chlorophenol, or 5-chloro-2-(2,4-dichlorophenoxy)phenol, or combinations thereof, and wherein the amount of phenolic compounds is from about 0.01 to about 0.2 parts by weight, and wherein said alcohol is isopropyl alcohol or n-propyl alcohol or combinations thereof in amount of from about 1 to about 20 parts by weight, and wherein the amount of said surfactant is from about 0.05 to about 3 parts by weight.

20. The process according to claim 17, including mixing said surfactant and said water, and separately mixing said two or more phenolic compounds and said alcohol, and subsequently combining said surfactant-water mixture and said phenolic-alcohol mixture, and subsequently adding said organic acids to said combined mixtures.

21. The process according to claim 18, including mixing surfactant and said water, and separately mixing said two or more phenolic compounds and said alcohol, and subsequently combining said surfactant-water mixture and said phenolic-alcohol mixture, and subsequently adding said organic acids to said combined mixtures.

22. The process according to claim 19, including mixing surfactant and said water, and separately mixing said two or more phenolic compounds and said alcohol, and subsequently combining said surfactant-water mixture and said phenolic-alcohol mixture, and subsequently adding said two or more organic acids to said combined mixtures.

23. The process of claim 15, wherein the composition is capable of a Log reduction of at least 4.0 with regard to AspergilIus niger.

24. The process of claim 19, wherein the composition is capable of a Log reduction of at least 5.0 with regard to Asperglllus niger.

25. The process of claim 20, wherein the composition is capable of a Log reduction of at least 6.0 with regard to Aspergilius niger.

26. The process of claim 22, wherein the composition is capable of a Log reduction of at least 6.0 with regard to Aspergillus niger.

27. The process according to claim 15, wherein the phenolic compounds comprise o-benzyl-p-chlorophenol and p-t-amylphenol, and wherein at least one of the organic carboxylic acids consists of a hydroxyl group containing carboxylic acid.

28. The process according to claim 19, wherein the phenolic compounds comprise o-benzyl-p-chlorophenol and p-t-amylphenol.

29. The process according to claim 22, wherein the phenolic compounds comprise o-benzyl-p-chlorophenol and p-t-amylphenol, and wherein at least one of the organic carboxylic acids consists of a hydroxyl group containing carboxylic acid.

30. The process for preparing a phenolic disinfectant composition according to claim 15, including irradiating said phenolic composition.

31. The process for preparing a phenolic disinfectant composition according to claim 22, including irradiating said phenolic composition.

32. The process for preparing a phenolic disinfectant composition according to claim 27, including irradiating said phenolic composition.

33. The process for preparing a phenolic disinfectant composition according to claim 29, including irradiating said phenolic composition.

34. An aqueous disinfectant composition, consisting essentially of:

water, wherein all parts are based upon 100 parts by weight of water;

a total of from 0.005 to 5 parts by weight of two or more phenolic compounds, wherein at least one of the phenolic compounds is an aromatic substituted phenol and wherein at least one of the phenolic compounds is an aliphatic substituted phenol;

a total of from 1.5 to 15 parts by weight of an alcohol, wherein said alcohol is an alkyl alcohol having from 1 to 10 carbon atoms or a glycol alcohol having from 2 to 12 carbon atoms or a combination thereof;

a total of from 0.01 to 15 parts by weight of a surfactant, wherein said surfactant is an anionic surfactant, a cationic surfactant, a nonanionic surfactant, or an amphoteric surfactant, or combinations thereof; and

a total of from 5 to 30 parts by weight of two or more organic carboxylic acids, and wherein the aqueous disinfectant composition has a pH from 2 to 5.

35. The aqueous disinfectant composition according to claim 34, wherein the amount of said phenolic compound is from 0.007 to 0.3 parts by weight, wherein at least one of the organic carboxylic acids consists of an aliphatic monocarboxylic acid having from 1 to about 10 carbon atoms, and wherein at least one of the organic carboxylic acids consists of a hydroxyl group containing carboxylic acid.

36. The aqueous disinfectant composition according to claim 35, wherein the amount of said organic carboxylic acids is from 2 to 20 parts by weight, and wherein said organic carboxylic acids each have a pKa from 1 to 6.5;

and wherein the amount of said surfactant is from 0.02 to 10 parts by weight.

37. The aqueous disinfectant composition according to claim 36, wherein said aliphatic substituted phenol has at least one substituent group comprising a hydrocarbon group having from 1 to 20 carbon atoms, wherein said organic acid consisting of the aliphatic monocarboxylic acid is formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, or combinations thereof, and wherein the amount of said two or more organic carboxylic acids is from 5 to 17 parts by weight.

38. The aqueous disinfectant composition according to claim 37, wherein said aliphatic substituted phenol is p-chloro-m-xylenol or p-t-amylphenol, or a combination thereof, wherein the aromatic subsitituted phenol is o-phenylphenol, o-benzyl-p-chlorophenol, or 5-chloro-2-(2,4-dichlorophenoxy)phenol, or combinations thereof, and wherein the amount of said phenolic compounds is from 0.01 to 0.2 parts by weight.

39. The aqueous disinfectant composition according to claim 38, wherein said alcohol is isopropyl alcohol or n-propyl alcohol or combinations thereof in amount of from 1.5 to 8 parts by weight, and wherein the amount of said surfactant is from 0.05 to 3 parts by weight.

40. The aqueous disinfectant composition according to claim 39, wherein the amount of said organic carboxylic acids is from 2 to 20 parts by weight, wherein said organic carboxylic acids each have a pKa from 1 to 6.5;

and wherein the surfactant is a fluorosurfactant.

41. The aqueous disinfectant composition according to claim 34, wherein the surfactant is a fluorosurfactant, and wherein said phenolic compounds comprise o-benzyl-p-chlorophenol and p-t-amylphenol, and wherein the amount of said phenolic compounds is from 0.007 to 0.2 parts by weight.