Flexible electrode array for artifical vision

• US 7,146,221 B2
• Filed: 11/16/2001
• Issued: 12/05/2006
• Est. Priority Date: 11/16/2001
• Status: Active Grant

• Current Assignee: Doheny Eye Institute, Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Maghribi, Mariam N., Krulevitch, Peter, Polla, Dennis L., Hamilton, Julie
• Primary Examiner(s): ALTER, ALYSSA MARGO
• Application Number:
  US09/992,248
• Publication Number:
  US 20030097166A1
• Time in Patent Office: 1,845 Days
• Field of Search: 607/36, 607/37, 607/53, 607/54, 607/116, 607/141, 607/142, 607/3, 623/24, 623/25, 623/6.63, 623/900, 623/901, 623905-907, 623/926, 257/527, 257/133, 257/E27.133
• US Class Current: 607/116
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: H05K 1/118 specially for flexible printed circuits, e.g. using folded portions
• CPC Class Codes: H05K 2201/0162 Silicon containing polymer, e.g. silicone
• CPC Class Codes: H05K 2201/09481 Via in pad; Pad over filled via if used for surface mounting H05K1/113
• CPC Class Codes: H05K 2203/0733 Method for plating stud vias, i.e. massive vias formed by plating the bottom of a hole without plating on the walls
• CPC Class Codes: H05K 3/205 using a pattern electroplated or electroformed on a metallic carrier
• CPC Class Codes: H05K 3/4007 Surface contacts, e.g. bumps H05K3/4092 takes precedence; deposition of finish layers on pads H05K3/24; forming solder bumps H05K3/3457
• CPC Class Codes: Y10S 623/90 Stent for heart valve
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device
• CPC Class Codes: Y10S 623/905 Eye
• CPC Class Codes: Y10S 623/926 Synthetic
• CPC Class Codes: Y10T 29/49128 Assembling formed circuit to base
• CPC Class Codes: Y10T 29/4913 Assembling to base an electrical component, e.g., capacitor, etc.
• CPC Class Codes: Y10T 29/49139 by inserting component lead or terminal into base aperture
• CPC Class Codes: Y10T 29/49147 Assembling terminal to base
• CPC Class Codes: Y10T 29/49155 Manufacturing circuit on or in base
• CPC Class Codes: Y10T 29/49165 by forming conductive walled aperture in base
• CPC Class Codes: Y10T 29/49169 Assembling electrical component directly to terminal or elongated conductor
• CPC Class Codes: Y10T 29/49224 with coating

Abstract

An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformable to the shape of the retina. Electrodes and conductive leads are embedded in the polymer substrate. The conductive leads and the electrodes transmit the signal representing the image to the cells in the retina. The signal representing the image stimulates cells in the retina.

Claims

1. An electrode array for an artificial vision system that is adapted to transfer an image signal to a retina having tissue containing cells wherein the electrode array is adapted to provide connection to the tissue containing the cells, consisting of:

a conformable substrate composed entirely of a flexible and stretchable polymer that has the ability to conform to various shapes of the tissue, and

micro-stimulator electrodes embedded in said conformable substrate composed entirely of a flexible and stretchable polymer for contacting the tissue wherein said conformable substrate is composed entirely of poly(dimethylsiloxane) and said conformable substrate composed entirely of poly(dimethylsiloxane) provides the support for said micro-stimulator electrodes.

2. The electrode array of claim 1, including conductive leads connected to said micro-stimulator electrodes.

3. The electrode array of claim 2, wherein the artificial vision system includes a device for transferring a visual image signal and wherein said conductive leads are connected to the device for transferring a visual image signal.

4. The electrode array of claim 2, wherein said micro-stimulator electrodes for contacting the tissue are micro-stimulator electrodes adapted to stimulate with a pattern of electrical pulses useful for stimulating the cells in the retina tissue.

5. The electrode array of claim 4, wherein said substrate is composed of a flexible and stretchable polymer composed entirely of poly(dimethylsiloxane) is a flexible and stretchable polymer of a shape and size that has the ability to conform to the shape of said retina tissue.

6. The electrode array of claim 5, wherein said conductive leads and said micro-stimulator electrodes are adapted to transmit the image signal to the cells in the retina tissue.

7. The electrode array of claim 6, wherein said micro-stimulator electrodes for contacting the tissue are micro-stimulator electrodes adapted to stimulate with a pattern of electrical pulses useful for stimulating the cells in the retina tissue and wherein the cells are retinal neurons.

8. The electrode array of claim 1, wherein said micro-stimulator electrodes embedded in said conformable substrate composed entirely of a flexible and stretchable polymer for contacting the tissue are micro-stimulator electrodes adapted to stimulate with a pattern of electrical pulses useful for stimulating the cells for transferring the image signal to the retina.

9. The electrode array of claim 1, wherein said flexible and stretchable polymer composed entirely of poly(dimethylsiloxane) is an elastomer.

10. The electrode array of claim 1, wherein said flexible and stretchable polymer composed entirely of poly(dimethylsiloxane) is an elastomer that is flexible.

11. An electrode array for an artificial vision system for receiving an image signal representing an image and adapted for transferring the image signal to a retina having tissue containing cells wherein the electrode array is adapted to provide connection to the tissue containing the cells, consisting of:

an electrode array including a conformable polymer substrate, said polymer substrate being a flexible and stretchable polymer composed entirely of poly(dimethylsiloxane) and having the ability to conform to the shape of the retina, and

micro-stimulator electrodes embedded in said conformable polymer substrate wherein said conformable substrate composed entirely of a flexible and stretchable polymer provides the support for said micro-stimulator electrodes.

12. The electrode array for an artificial vision system of claim 11, wherein said micro-stimulator electrodes are embedded in said flexible and stretchable polymer substrate composed entirely of poly(dimethylsiloxane) and said micro-stimulator electrodes are adapted to contact the retina and are adapted to have the image signal stimulate the cells in the retina.

13. The electrode array for an artificial vision system of claim 11, including conductive leads connected to said micro-stimulator electrodes wherein said conductive leads and said micro-stimulator electrodes are adapted to transmit the signal representing the image to the cells in the retina.

14. The electrode array for an artificial vision system of claim 13, wherein said micro-stimulator electrodes are micro-stimulator electrodes adapted to stimulate with a pattern of electrical pulses useful for stimulating the cells in the retina tissue and wherein the cells are retinal neurons.

15. An electrode array implant for an artificial vision system for receiving an image signal representing an image and adapted to transmit the image into an eye and to a retina having tissue containing cells, consisting of:

an implant adapted to be connected to the eye and the retina comprising a flexible polymer substrate, said flexible polymer substrate consisting of poly(dimethylsiloxane) and being flexible and stretchable and having the ability to conform to the shape of the retina, and micro-stimulator electrodes embedded in said flexible polymer substrate comprising poly(dimethylsiloxane) wherein said conformable substrate comprising poly(dimethylsiloxane) provides the support for said micro-stimulator electrodes.

16. The electrode array for an artificial vision system of claim 15, wherein said micro-stimulator electrodes are embedded in said flexible polymer substrate consisting of poly(dimethylsiloxane) and are adapted to contact the retina and the signal representing the image is adapted to stimulate the cells in the retina.

17. The electrode array for an artificial vision system of claim 15, including conductive leads connected to said micro-stimulator electrodes wherein said conductive leads and said micro-stimulator electrodes are adapted to transmit the signal representing the image to the cells in the retina.

18. The electrode array of claim 17, wherein said micro-stimulator electrodes are adapted to transmit the signal representing the image to the cells in the retina and wherein the cells are retinal neurons.