Polymer substrate coated with weak cationic-exchange functional layer

• US 7,147,891 B2
• Filed: 02/11/2004
• Issued: 12/12/2006
• Est. Priority Date: 02/11/2004
• Status: Active Grant

• Current Assignee: Dionex Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Dionex Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Rey, Maria, Bordunov, Andrei V., Pohl, Christopher A.
• Primary Examiner(s): LE, HOA T
• Application Number:
  US10/778,007
• Publication Number:
  US 20050175851A1
• Time in Patent Office: 1,035 Days
• Field of Search: 521/27, 521/38, 427/212, 210/263, 210/506
• US Class Current: 427/212
• CPC Class Codes: B01D 15/362 Cation-exchange
• CPC Class Codes: B01J 20/28097 being coated, filled or plugged with specific compounds
• CPC Class Codes: B01J 20/3208 Polymeric carriers, supports or substrates
• CPC Class Codes: B01J 20/3268 Macromolecular compounds
• CPC Class Codes: B01J 20/327 Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3282 Crosslinked polymers
• CPC Class Codes: B01J 39/26 Cation exchangers for chromatographic processes
• CPC Class Codes: B01J 47/018 Granulation; Incorporation of ion-exchangers in a matrix; Mixing with inert materials
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31536 Including interfacial reaction product of adjacent layers
• CPC Class Codes: Y10T 428/31931 Polyene monomer-containing

Abstract

A method for making a weak cation-exchange (carboxylic acid) medium comprising contacting a solution of a functional organic polymer having carbon to carbon double bond unsaturation and having weak cationic exchange functional moieties or precursors thereof in a solvent with a substrate having an organic polymer surface, evaporating said solvent and breaking said double bond under conditions to cause the functional organic polymer to covalently bond to the substrate surface and to cross-link to form a cross-linked functional polymer layer covalently bound to the substrate surface. The medium produced by the method.

Claims

1. A method of making a weak cation exchange medium comprising contacting a solution of a functional organic polymer having carbon to carbon double bond unsaturation and having weak cationic exchange functional moieties or precursors thereof in a solvent with at least one substrate having an organic polymer surface, removing said solvent from said solution by evaporation and thereafter breaking said double bond in the substantial absence of said evaporated solvent under conditions to cause said functional organic polymer to covalently bond to said substrate surface and to cross-link to form a cross-linked functional polymer layer covalently bound to the substrate surface.

2. The method of claim 1 in which said substrate surface is porous and said functional polymer solution flows into the pores of said substrate surface prior to a solvent evaporation and breaking of said double bond.

3. The method of claim 2 further comprising a plurality of said substrates in the form of particles suitable for use as a weak cation exchange chromatographic medium.

4. The method of claim 3 in which said substrate surface comprises a cross-linked polymer having residual unsaturation and said covalent bonding with said substrate surface is through said residual unsaturation.

5. The method of claim 4 in which said plurality of substrates comprise particles formed of said cross-linked polymer.

6. The method of claim 1 further comprising packing said particles in a chromatographic column.

7. The method of claim 1 in which said weak cation exchange groups comprise carboxylic acid moieties.

8. The method of claim 1 in which said weak cationic exchange moieties comprise succinic acid.

9. The method of claim 1 in which said functional organic polymer comprises a copolymer of butadiene and a weak acid cation exchange moiety or precursor thereof.

10. The method of claim 1 where said functional organic polymer comprises

11. The method of claim 10 in which said weak cation functional group comprises carboxylic acid.