Pharmaceutical compositions for headache, migraine, nausea and emesis
First Claim
1. A method of treating headache or migraine, the method comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a composition consisting essentially of (a) a compound selected from the group consisting of S-methylisothiouronium methylphosphite;
- S-methylisothiouronium dimethylphosphate;
S-ethylisothiouronium metaphosphate;
S-ethylisothiouronium ethylphosphite;
S-ethylisothiouronium diethylphosohate;
S-propylisothiourium propylphosphite;
S-isopropylisothiouronium metaphosphate;
S-isopropylisothiouronium isopropylphosphite;
S-butylisothiouronium dibutylphosphate; and
S-isobutylisothiouronium isobutylphosphite, and (b) a pharmaceutically acceptable carrier or diluent;
wherein the composition is formulated as tablets or capsules.
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Accused Products
Abstract
S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.
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Citations
24 Claims
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1. A method of treating headache or migraine, the method comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a composition consisting essentially of (a) a compound selected from the group consisting of S-methylisothiouronium methylphosphite;
- S-methylisothiouronium dimethylphosphate;
S-ethylisothiouronium metaphosphate;
S-ethylisothiouronium ethylphosphite;
S-ethylisothiouronium diethylphosohate;
S-propylisothiourium propylphosphite;
S-isopropylisothiouronium metaphosphate;
S-isopropylisothiouronium isopropylphosphite;
S-butylisothiouronium dibutylphosphate; and
S-isobutylisothiouronium isobutylphosphite, and (b) a pharmaceutically acceptable carrier or diluent;
wherein the composition is formulated as tablets or capsules. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- S-methylisothiouronium dimethylphosphate;
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13. A method of alleviating nausea or vomiting, the method comprising the step of administering to a subject suffering from nausea or vomiting a therapeutically effective amount of a composition consisting essentially of (a) a compound selected from the group consisting of S-methylisothiouronium methylphosphite;
- S-methylisothiouronium dimethylphosphate;
S-ethylisothiouronium metaphosphate;
S-ethylisothiouronium ethylphosphite;
S-ethylisothiouronium diethylphosphate;
S-propylisothiouronium propylphosphite;
S-isopropylisothiouronium metaphosphate;
S-isopropylisothiouronium isopropylphosphite;
S-butylisothiouronium dibutylphosphate; and
S-isobutylisothiouronium isobutylphosphite, and (b) a pharmaceutically acceptable carrier or diluent;
wherein the composition is formulated as tablets or capsules. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
- S-methylisothiouronium dimethylphosphate;
- 22. A method of alleviating nausea or vomiting resulting from the administration of an anticancer agent or treatment, the method comprising the step of administering to a subject in need thereof a therapeutically effective amount of a composition that comprises (a) a compound having the general formula:
Specification