Enhanced circulation effector composition and method
First Claim
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1. A liposome composition, comprisingliposomes, each having an outer layer of hydrophilic chains, andan effector molecule attached to the distal ends of at least a portion of said chains,wherein said liposomes provide a polyvalent presentation of said effector molecule.
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Abstract
A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
14 Citations
48 Claims
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1. A liposome composition, comprising
liposomes, each having an outer layer of hydrophilic chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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7. A liposome composition for use in treating a condition mediated by binding of one binding member to a second binding member, comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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13. A liposome composition for use in treating a condition mediated by binding of one binding member, which is present in the bloodstream, to a second binding member, comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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19. A liposome composition for use in treating a condition mediated by binding of one binding member, which is a pathogen or cell in the bloodstream, to a second binding member comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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25. A liposome composition for use in treating a condition mediated by binding of one binding member to a second binding member, which is a target cell, comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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31. A liposome composition for use in treating a condition mediated by binding of one binding member, which is a pathogen, to a second binding member, which is a target cell, comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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37. A liposome composition for use in treating a condition mediated by binding of one binding member, which is a cell in the bloodstream, to a second binding member, which is a target cell, comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
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43. A liposome composition for use in treating a condition mediated by binding of one binding member, which is a pathogen or a cell in the bloodstream, to a second binding member, which is a target cell, comprising
liposomes, each having an outer layer of hydrophilic polymer chains, and an effector molecule attached to the distal ends of at least a portion of said chains, wherein said liposomes provide a polyvalent presentation of said effector molecule.
Specification