Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance
First Claim
1. A biosensor comprising an analyte sensor having an external surface, and an accessory material coated with a hydrophilic polymer provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor, wherein the accessory material is a fiber modified to deliver dexamethasone or a salt thereof.
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Accused Products
Abstract
A biosensor including an external surface, and an accessory material in close proximity to the external surface. The accessory material includes a coating containing a hydrophilic material and/or a fiber modified to deliver a therapeutic agent. The biosensor modifies a biological response to the biosensor upon contact with a tissue, such as upon implantation into the skin of a subject, thereby reducing biofouling, inflammation and other undesirable tissue responses that interfere with biosensor performance. The biosensor can be any biocompatible sensor, suitable for short- or long-term use. Preferably, the biosensor is an enzymatic or electrochemical sensor, such as a glucose sensor. Also provided are a method of producing a biosensor and a method of delivering a biologically active substance to a subject.
553 Citations
26 Claims
- 1. A biosensor comprising an analyte sensor having an external surface, and an accessory material coated with a hydrophilic polymer provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor, wherein the accessory material is a fiber modified to deliver dexamethasone or a salt thereof.
- 16. A biosensor comprising a sensor having an external surface, and an accessory material provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor, wherein the accessory material is a fiber modified to deliver a therapeutic agent, and wherein the therapeutic agent comprises cefazolin or benzalkonium chloride, wherein the fiber comprises cotton, polypropylene polyurethane, polyesrer, polylactic acid (PLA), polyglycolic acid (PGA), or a co-polymer of lactic acid and glycolic acid (PLGA).
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18. A biosensor comprising an sensor having an external surface, and an accessory material provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor, wherein the accessory material is a fiber modified to deliver dexamethasone or a salt thereof, wherein the biosensor comprises an enzymatic, molecular recognition, oprochemical or electrochemical sensor.
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19. A biosensor comprising an sensor having an external surface, and an accessory material provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor, wherein the accessory material is a fiber modified to deliver dexamethasone or a salt thereof, wherein the biosensor comprises a glucose sensor.
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20. A biosensor comprising a sensor having an external surface, and an accessory material provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor, wherein the accessory material is a fiber modified to deliver a therapeutic agent, and wherein the therapeutic agent comprises cefazolin or benzalkonium chloride, the biosensor further comprising an additional therapeutic agent, which additional agent comprises anti-inflammatory, anti-bacterial, anti-viral, anti-coagulant, anti-proliferative or disinfecting agent, or a growth factor.
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21. A method of producing a biosensor, comprising:
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providing an accessory material in close proximity to the biosensor;
modifiying the biological response of a tissue that is in contact with the biosensor using the accessory material,delivering dexamethasone or a salt thereof, cefazolin or benzalkonium chloride using the accessory material; and
coating the fiber with a hydrophilic polymer. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification