Hemostatic system and components for extracorporeal circuit
First Claim
1. A system for use in combination with an extracorporeal blood flow circuit, the system comprising:
- a) one or more automated sensor modules adapted to monitor, directly or indirectly, the presence of one or more blood analytes, and b) one or more regulating modules adapted to affect the presence, concentration and/or activity of one or more blood analytes, wherein the sensor module is adapted to incorporate flow injection analysis (“
FIA”
) techniques, and comprises;
i) a blood withdrawal component with in-line access, ii) an analytical component, and iii) a readout component.
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Abstract
A method and system for use in the course of extracorporeal blood flow, e.g., cardiopulmonary bypass, dialysis, and angioplasty procedures, in order to reduce or minimize inflammation, excessive bleeding, and other undesirable side effects. The system can include one or more automated blood parameter sensor modules and one or more blood parameter regulating modules. The system is particularly well suited to monitor and/or regulate blood parameters that include blood analytes (e.g., biomolecules, drugs or metabolites) as well as blood functions (e.g., clotting time, fibrinolytic activity, immune response). The system is particularly well suited for use in the management of clotting (e.g., heparing/protamine) and bleeding (e.g., aprotinin).
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Citations
22 Claims
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1. A system for use in combination with an extracorporeal blood flow circuit, the system comprising:
- a) one or more automated sensor modules adapted to monitor, directly or indirectly, the presence of one or more blood analytes, and b) one or more regulating modules adapted to affect the presence, concentration and/or activity of one or more blood analytes, wherein the sensor module is adapted to incorporate flow injection analysis (“
FIA”
) techniques, and comprises;
i) a blood withdrawal component with in-line access, ii) an analytical component, and iii) a readout component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- a) one or more automated sensor modules adapted to monitor, directly or indirectly, the presence of one or more blood analytes, and b) one or more regulating modules adapted to affect the presence, concentration and/or activity of one or more blood analytes, wherein the sensor module is adapted to incorporate flow injection analysis (“
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12. A method for monitoring and regulating blood analytes in the course of extracorporeal blood flow, the method comprising:
- a) providing an extracoporeal blood flow circuit comprising, in the order of blood flow, a reservoir, a pump, and oxygenator, a filter, together with associated tubing, connectors and controls, b) providing a system comprising i) one or more automated sensor modules adapted to monitor, directly or indirectly, the presence of one or more blood analytes, and ii) one or more regulating modules adapted to affect the presence, concentration and/or activity of one or more blood analytes, c) employing the sensor module(s) to monitor one or more blood analytes, and d) employing the filter module(s) to affect the presence, concentration and/or activity of one or more blood analytes, wherein the sensor module is adapted to incorporate flow injection analysis (“
FIA”
) techniques, and comprises;
i) a blood withdrawal component with in-line access, ii) an analytical component, and iii) a readout component. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- a) providing an extracoporeal blood flow circuit comprising, in the order of blood flow, a reservoir, a pump, and oxygenator, a filter, together with associated tubing, connectors and controls, b) providing a system comprising i) one or more automated sensor modules adapted to monitor, directly or indirectly, the presence of one or more blood analytes, and ii) one or more regulating modules adapted to affect the presence, concentration and/or activity of one or more blood analytes, c) employing the sensor module(s) to monitor one or more blood analytes, and d) employing the filter module(s) to affect the presence, concentration and/or activity of one or more blood analytes, wherein the sensor module is adapted to incorporate flow injection analysis (“
Specification