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Composition for sustained delivery of hydrophobic drugs and process for the preparation thereof

  • US 7,153,520 B2
  • Filed: 12/07/2001
  • Issued: 12/26/2006
  • Est. Priority Date: 12/07/2000
  • Status: Expired due to Term
First Claim
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1. A liquid polymeric composition for the sustained delivery of a poorly water-soluble drug comprising:

  • i) an amphiphilic diblock copolymer;

    ii) a poorly water-soluble drug;

    iii) a biodegradable polymer; and

    ,iv) liquid poly(ethylene glycol);

    wherein said amphiphilic diblock copolymer, said poorly water-soluble drug and said biodegradable polymer are dissolved or dispersed in said liquid poly(ethylene glycol); and

    wherein said composition is an injectable liquid at a room temperature and, upon being injected into a body, forms an implant containing polymeric micelles wherein said poorly water-soluble drugs are physically trapped and wherein said amphiphilic diblock copolymer is composed of a hydrophilic polyalkylene glycol block selected from the group consisting of polyethylene glycol, monoalkoxypolyethylene glycol and monoacyloxypolyethylene glycol and a hydrophobic biodegradable polymer block selected from the group consisting of polylactides, polycaprolactone, poly(lactide-co-glycolide), poly(lactide-co-caprolactone), poly(lactide-co-p-dioxanone), polyorthoesters, polyanhydrides, poly(amino acid) and polycarbonates.

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