Sorbefacients and preparations for percutaneous absorption containing the same

• US 7,153,522 B1
• Filed: 10/14/1999
• Issued: 12/26/2006
• Est. Priority Date: 10/14/1998
• Status: Expired due to Term

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Maki, Masayoshi, Ikeura, Yasuhiro
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US09/807,337
• Time in Patent Office: 2,630 Days
• Field of Search: 424448-449, 424/486
• US Class Current: 424/449
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7076 the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
• CPC Class Codes: A61P 15/12 for climacteric disorders

Abstract

Percutaneous sorbefacients comprising hexylene glycol and 1-menthol, more particularly, percutaneous sorbefacients for female hormones or derivatives thereof; and preparations for percutaneous absorption which comprise a styrene/isoprene/styrene block copolymer and/or polyisobutylene, a softener and a tackifier as the base components, hormones, in particular, follicle hormone and/or luteal hormone as the drug component and hexylene glycol and 1-menthol as a sorbefacient.

Claims

1. A base for a percutaneously absorbing preparation, comprising 10–

40% by weight of styrene-isoprene-styrene block copolymer, 2–

10% by weight of polyisobutylene, 10–

60% by weight of softener, 20–

60% by weight of tackifier, 1–

10% by weight of hexylene glycol and 0.1–

7% by weight of 1-menthol.

2. A percutaneously absorbing preparation wherein a pharmaceutical agent is contained as an effective ingredient in the base for a percutaneously absorbing preparation according to claim 1.

3. The percutaneously absorbing preparation according to claim 2, wherein the pharmaceutical agent is follicular hormone and/or luteinizing hormone.

4. The percutaneously absorbing preparation according to claim 3, wherein the follicular hormone is estradiol, estrone, estriol, equilin or equilenin or a derivative thereof and its compounding amount if is 0.1–

5% by weight.

5. The percutaneously absorbing preparation according to claim 3, wherein the luteinizing hormone is norethisterone, norethisterone acetate, norethisterone coanthale or progesterone and its compounding amount is 0.5–

10% by weight.