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Tamoxifen and 4-hydroxytamoxifen-activated system for regulated production of proteins in eukaryotic cells

  • US 7,153,685 B2
  • Filed: 03/11/2002
  • Issued: 12/26/2006
  • Est. Priority Date: 03/11/2002
  • Status: Active Grant
First Claim
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1. An isolated polynucleotide, comprising:

  • a first polynucleotide; and

    a second polynucleotide operably linked to the first polynucleotide;

    wherein when the first polynucleotide is inserted into a promoter region of a gene, enhances transcription of the gene, when the first polynucleotide is bound by a mutant estrogen receptor to which is bound 4-hydroxytamoxifen,the first polynucleotide comprises nucleotides 2–

    6 and 10–

    14 of SEQ ID NO;

    75, andthe mutant estrogen receptor has the amino acid sequence of SEQ ID NO;

    4.

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