Pentopyranosyl nucleic acid arrays, and uses thereof

• US 7,153,955 B2
• Filed: 05/16/2002
• Issued: 12/26/2006
• Est. Priority Date: 09/22/1997
• Status: Expired due to Fees

• Current Assignee: Sanofi-Aventis SA (Sanofi )
• Original Assignee: Nanogen Recognomics GmbH
• Inventors: Windhab, Norbert, Burdinski, Gerhard, Brandstetter, Tilmann, Miculka, Christian
• Primary Examiner(s): Zara, Jane
• Application Number:
  US10/150,402
• Publication Number:
  US 20030039997A1
• Time in Patent Office: 1,685 Days
• Field of Search: 536/26.9, 536/1.11, 536/23.1, 536/25.3, 536/26.71, 536/24.3, 536/27.1, 435/6, 435/88, 435/7.1, 435/91.1, 435/455, 435/91.5, 435/333, 435/91.3, 530/300, 530/324, 530/325, 530/387.1
• US Class Current: 536/26.9
• CPC Class Codes: A61K 47/549 Sugars, nucleosides, nucleotides or nucleic acids
• CPC Class Codes: A61K 49/0013 Luminescence
• CPC Class Codes: C07H 19/04 Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
• CPC Class Codes: C07H 21/00 Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• CPC Class Codes: C07H 21/02 with ribosyl as saccharide radical
• CPC Class Codes: C07H 21/04 with deoxyribosyl as saccharide radical
• CPC Class Codes: G01N 33/532 Production of labelled immunochemicals
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
• CPC Class Codes: Y10S 977/728 Nucleic acids, e.g. DNA or RNA
• CPC Class Codes: Y10S 977/80 Nucleic acid, e.g. DNA or RNA
• CPC Class Codes: Y10S 977/836 having biological reactive capability
• CPC Class Codes: Y10S 977/894 having step or means utilizing biological growth
• CPC Class Codes: Y10S 977/896 Chemical synthesis, e.g. chemical bonding or breaking
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis
• CPC Class Codes: Y10S 977/914 Protein engineering
• CPC Class Codes: Y10S 977/915 Therapeutic or pharmaceutical composition
• CPC Class Codes: Y10S 977/924 using nanostructure as support of dna analysis
• CPC Class Codes: Y10S 977/925 Bioelectrical

Abstract

The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II)

their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.

Claims

1. A conjugate comprising a 4′

,2′

-pentopyranosylnucleic acid covalently bonded through a linker to a biomolecule selected from the group consisting of a peptide, protein, nucleic acid, antibody, functional antibody moiety, DNA, and RNA, wherein the biomolecule does not non-covalently bond or hybridize to the pentopyranosylnucleic acid.

2. The conjugate according to claim 1, wherein the biomolecule is a peptide, protein or a nucleic acid.

3. The conjugate according to claim 1, wherein the biomolecule is an antibody, a functional moiety of an antibody, a DNA, or an RNA.