Intradermal delivery device

• US 7,156,838 B2
• Filed: 08/23/2004
• Issued: 01/02/2007
• Est. Priority Date: 04/02/2002
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Wilkinson, Bradley M., Hwang, Charles G., Gabel, Jonathan B.
• Primary Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US10/924,118
• Publication Number:
  US 20050027242A1
• Time in Patent Office: 862 Days
• Field of Search: 604/890.1, 604 19- 22, 604/48, 604/93.01, 604/131, 604/132, 604/133, 604/134, 604/135, 604/151, 604/153, 604/164.04, 604/173, 604/174, 604/179, 604/180, 604/185, 604/212, 604/214, 604/216, 604/239, 604/246, 604/272, 604/304, 604/305, 604/307
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14248 of the skin patch type

Abstract

A delivery device for delivering a substance intradermally into the skin of a patient including a housing for contacting the surface of the skin and a disposable cartridge to be received in the housing. The cartridge includes an internal reservoir containing a substance to be delivered to the patient, a plurality of micro skin penetrating members and a fluid channel extending between the micro skin penetrating members and the reservoir. The housing includes a bottom wall with a central opening and a cover member. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient. The cover is closed onto the cartridge to dispense the substance from the cartridge through the micro skin penetrating members and into or through the skin of the patient.

Claims

1. A drug delivery device for indicating the delivery of a substance comprising:

a housing;

a cartridge in said housing, said cartridge defining an internal reservoir adapted to contain a pre-selected amount of a substance to be delivered to a patient, thereby defining a pre-selected dose;

a dispensing member comprising an elastic member for contacting said cartridge operable to apply a dispensing pressure to said cartridge, said elastic member having a first position wherein said reservoir contains the dose and a second position, wherein said reservoir does not contain the dose;

an indicator responsive to said elastic member for indicating that said dose is dispensed from said cartridge, and;

at least one skin penetrating member, said skin penetrating member having a length sufficient to penetrate at least the stratum corneum of the skin of said patient, said skin penetrating member adapted for selective fluid communication with said reservoir for delivering a substance in said reservoir to the patient;

wherein said dispensing member further comprises a cover hinged to said housing, said elastic member having a first end fixed to said cover and a second free end; and

wherein said indicator is visible through said cover when said elastic member is in said second position and is not visible through said cover when said elastic member is in said first position.

2. The delivery device of claim 1, wherein said skin penetrating member is coupled to said cartridge, said skin penetrating member having a base, an outer end and a passage extending between said base and said outer end, and wherein said base is adapted to be placed in fluid communication with said reservoir.

3. The delivery device of claim 1, wherein said housing has a top edge, a bottom edge and an internal chamber dimensioned to receive said cartridge, said housing further including a coupling member for coupling said device to the skin of the patient.

4. The delivery device of claim 3, wherein said coupling member on said housing is a strap for coupling to the skin of the patient.

5. The delivery device of claim 1, wherein the indicator is a displaceable member.

6. The delivery device of claim 1, wherein the indicator is a deformable member.

7. The delivery device of claim 1, wherein the indicator is adapted to contact said cartridge.

8. The delivery device of claim 7, wherein the indicator is a deformable member.

9. The delivery device of claim 1, wherein said cover includes a window for viewing said indicator when said elastic member is in said second position.

10. The delivery device of claim 1, wherein said skin penetrating member has a length of about 50 microns to about 5000 microns.

11. The delivery device of claim 1, wherein said skin penetrating member has a length of about 500 microns to about 3000 microns.

12. The delivery device of claim 1, wherein said skin penetrating member has a length of about 500 microns to about 1000 microns.

13. The delivery device of claim 1 wherein said skin penetrating member is one of an array of skin penetrating members, each adapted to be placed in fluid communication with said reservoir.

14. A drug delivery device for indicating the delivery of a substance comprising:

a housing;

a cartridge defining an internal reservoir adapted to contain a pre-selected amount of a substance to be delivered to a patient, thereby defining a pre-selected dose;

a dispensing member comprising an elastic member for contacting said cartridge operable to apply a dispensing pressure to said cartridge, said elastic member having a first position wherein said reservoir contains the dose and a second position, wherein said reservoir does not contain the dose;

an indicator responsive to said elastic member for indicating that said dose is dispensed from said cartridge, and;

at least one skin penetrating member, said skin penetrating member having a length of about 500 microns to about 3000 microns, said skin penetrating member adapted for selective fluid communication with said reservoir for delivering a substance in said reservoir to the patient;

wherein said dispensing member further comprises a cover hinged to said housing, said elastic member having a first end fixed to said cover and a second free end; and

wherein said indicator is visible through said cover when said elastic member is in said second position and is not visible through said cover when said elastic member is in said first position.

15. The delivery device of claim 14, wherein the indicator is a displaceable member.

16. The delivery device of claim 14, wherein the indicator is a deformable member.

17. The delivery device of claim 14, wherein the indicator is adapted to contact said cartridge.

18. The delivery device of claim 17, wherein the indicator is a deformable member.

19. The delivery device of claim 14, wherein said cover includes a window for viewing said indicator when said elastic member is in said second position.

20. The delivery device of claim 14, wherein said skin penetrating member is one of an array of skin penetrating members, each adapted to be placed in fluid communication with said reservoir.