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Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders

  • US 7,157,418 B1
  • Filed: 07/22/1999
  • Issued: 01/02/2007
  • Est. Priority Date: 07/22/1998
  • Status: Expired due to Fees
First Claim
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1. A method for inhibiting proliferation or migration of activated immune effector cells, comprising administering a conjugate to an animal, whereby proliferation or migration of the immune effector cells is inhibited, wherein:

  • the conjugate comprises a targeted agent or a portion thereof and a chemokine receptor targeting agent or a portion thereof sufficient to bind to a chemokine receptor on immune effector cells and facilitate internalization of the conjugate;

    the chemokine receptor targeting agent is a chemokine, an antibody that specifically binds to a chemokine receptor or a fragment of the chemokine or antibody, wherein the chemokine, antibody or fragment thereof binds to the receptor and internalizes the targeted agent in a cell;

    the targeted agent or portion thereof, when internalized in a cell, alters metabolism or gene expression in the cell, regulates or alters protein synthesis in the cell, inhibits proliferation of the cell or kills the cell; and

    the conjugate binds to a chemokine receptor resulting in internalization of the targeted agent in cells bearing the receptor.

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